CBD gel shows promise for fragile x behavior issues in major trial
NCT ID NCT04977986
First seen Jan 05, 2026 · Last updated May 14, 2026 · Updated 14 times
Summary
This study tested a CBD gel (ZYN002) applied to the skin in children, teens, and young adults with Fragile X Syndrome. The goal was to see if it could ease difficult behaviors like irritability and social withdrawal. 215 participants received either the gel or a placebo for up to 18 weeks, and caregivers reported changes using a standard behavior checklist.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Amnova Clinical Research, LLC
Irvine, California, 92604, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Central States Research
Tulsa, Oklahoma, 74136, United States
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Children's National Medical center
Washington D.C., District of Columbia, 20010, United States
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Genetics Clinics Australia
Melbourne, Victoria, 3161, Australia
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Greenwood Genetic Center
Greenville, South Carolina, 29605, United States
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Health New Zealand - Te Whatu Ora - Wellington Hospital
Newtown, Wellington Region, 6021, New Zealand
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Kennedy Krieger Institute
Baltimore, Maryland, 21205, United States
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King's College
London, United Kingdom
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Lady Cilento Children's Hospital - South Brisbane
Brisbane, Queensland, 4101, Australia
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Leicester Clinical Research
Leicester, United Kingdom
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Manchester University NHS Foundation Trust
Manchester, United Kingdom
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Penn State Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Rare Disease Research
Atlanta, Georgia, 30318, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Science 37
Culver City, California, 90230, United States
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The Fragile X Spectrum Disorder Clinic at Icahn School of Medicine at Mount Sinai, Division of Medical Genetics
New York, New York, 10029, United States
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Thompson Autism Center CHOC
Orange, California, 92868, United States
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UC Davis Health System, MIND Institute
Sacramento, California, 95817, United States
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University of Edinburgh
Edinburgh, United Kingdom
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University of Miami
Miami, Florida, 33136, United States
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University of Minnesota Fragile X Clinic (Voyager Clinic)
Minneapolis, Minnesota, 55454, United States
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University of Mississippi
Jackson, Mississippi, 39216, United States
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Wellcome HRB Clinical Research Facility
Dublin, Ireland
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Westmead Children's Hospital
Sydney, New South Wales, 2145, Australia
Conditions
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