New hope for controlling devastating seizures in rare genetic disorder
NCT ID NCT05064878
Summary
This study is testing whether adding the medication ZX008 (fenfluramine) to existing treatments can better control seizures in people with CDKL5 deficiency disorder, a rare genetic condition that causes severe epilepsy and developmental delays. The trial involves children and adults aged 1-35 who continue to have frequent seizures despite trying multiple anti-seizure medications. Researchers will measure whether ZX008 reduces seizure frequency compared to a placebo over 20 weeks, followed by a longer open-label extension period.
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Contacts and locations
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Locations
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San Francisco, California, 94158, United States
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Barcelona, Spain
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Madrid, Spain
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Santiago de Compostela, Spain
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Boston, Massachusetts, 02115, United States
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Philadelphia, Pennsylvania, 19104, United States
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Florence, Italy
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Verona, Italy
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Genova, Italy
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Roma, Italy
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Roma, Italy
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Modena, Italy
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Memphis, Tennessee, 38105, United States
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Detroit, Michigan, 48201, United States
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Zwolle, Netherlands
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Los Angeles, California, 90095, United States
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Washington D.C., District of Columbia, 20010, United States
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Shizuoka, Japan
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Niigata, Japan
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Hiroshima, Japan
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Ōmura, Japan
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Birmingham, Alabama, 35233, United States
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Atlanta, Georgia, 30329, United States
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Cleveland, Ohio, 44195, United States
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Chapel Hill, North Carolina, 27514, United States
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Austin, Texas, 78731, United States
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Aurora, Colorado, 80045, United States
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Dublin, Ireland
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Tel Aviv, Israel
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Ramat Gan, Israel
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Petah Tikva, Israel
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Lisbon, Portugal
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Porto, Portugal
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Linz, Austria
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Tbilisi, Georgia
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Dubai, United Arab Emirates
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London, United Kingdom
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Sheffield, United Kingdom
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Bristol, United Kingdom
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Manchester, United Kingdom
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Edegem, Belgium
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Brussels, Belgium
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Vogtareuth, Germany
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Bielefeld, Germany
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Kiel, Germany
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Kehl-Kork, Germany
Conditions
Explore the condition pages connected to this study.