New drug cocktail aims to fight lung cancer in the brain
NCT ID NCT07361705
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests whether adding zorifertinib to the standard drug osimertinib is safe and helpful for people with advanced lung cancer that has spread to the membranes around the brain. About 42 participants will receive the combination pills daily. The main goal is to find the best dose and check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Zorifertinib and osimertinib combination therapy
- What this could lead to
- If this combination proves safe and effective, it could offer a new treatment option for patients with advanced lung cancer that has spread to the brain lining after standard therapy.
- What could go wrong
- This is a very early Phase 1 trial with only 42 participants, focused on safety and dosing. The combination may not work better than existing treatments, and side effects could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cancer Hospital Chinese Academy of Medical Sciences
RECRUITINGBeijing, Beijing Municipality, 100021, China
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Chinese Academy of Medical Sciences Cancer Hospital Shenzhen Hospital
RECRUITINGGuangzhou, Province, 518117, China
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Henan Cancer Hospital
RECRUITINGHenan, Province, 450008, China
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Shanxi Cancer Hospital
RECRUITINGShanxi, Province, 030013, China
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The First Affiliated Hospital of China Medical University
RECRUITINGShengyang, City, 110001, China