New pill could outperform chemo for HER2 lung cancer patients

NCT ID NCT06151574

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 19 times

Summary

This study tests a new daily pill, zongertinib, against standard chemotherapy for people with advanced non-small cell lung cancer that has a specific HER2 gene change. About 428 adults who have not had prior treatment for their advanced cancer will be randomly assigned to receive either the pill or standard IV chemo. The main goal is to see if zongertinib can delay cancer growth longer than current therapy.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LUNG CANCER, NON-SQUAMOUS, NON-SMALL CELL are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • A. O. Ospedale Circolo Fond. Macchi

    Varese, 21100, Italy

  • AOU Policlinico Umberto I

    Roma, 00161, Italy

  • Aichi Cancer Center Hospital

    Aichi, Nagoya, 464-8681, Japan

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Associacao Dr. Bartholomeu Tacchini

    Bento Gonçalves, 95700-084, Brazil

  • Austin Health

    Heidelberg, Victoria, 3084, Australia

  • Azienda Ospedaliera Unversitaria di Parma

    Parma, 43100, Italy

  • Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania

    Catania, 95123, Italy

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Bradford Hill- Centro de Investigación Clínica

    Recoleta, 8420383, Chile

  • Brussels - HOSP Jules Bordet

    Anderlecht, 1070, Belgium

  • CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia

    Santo André, 09060-650, Brazil

  • CTR Leon Berard

    Lyon, 69373, France

  • Cancer Care Specialists

    Reno, Nevada, 89511, United States

  • Cancer Hospital of Chinese Academy of Medical Science

    Beijing, 1000021, China

  • Carolina Blood and Cancer Care Associates, PA

    Rock Hill, South Carolina, 29732, United States

  • Centro Hospitalar Lisboa Norte Hospital Pulido Valente

    Lisbon, 1769-001, Portugal

  • Centro Oncologico Riojano Integral (CORI)

    La Rioja, F5300COE, Argentina

  • Chang Gung Memorial Hospital, Linkou

    Taoyuan District, 330, Taiwan

  • Chung Shan Medical University Hospital

    Taichung, 404, Taiwan

  • Chungbuk National University Hospital

    Cheongiu, 28644, South Korea

  • Clearview Cancer Institute

    Huntsville, Alabama, 35805, United States

  • ClinRé 001-022 (Premier Cancer Care and Infusion Center)

    Fresno, California, 93710, United States

  • Clinic Floridsdorf

    Vienna, 1210, Austria

  • Clinica Adventista Belgrano

    CABA, 1430, Argentina

  • Complejo Hospitalario Universitario A Coruña

    A Coruña, 15006, Spain

  • FAICIC S de RL de C.V.

    Veracruz, 91900, Mexico

  • First Affiliated Hospital of Xiamen University

    Xiamen, 361003, China

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032, China

  • Fujian Cancer Hospital

    Fuzhou, 350014, China

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto

    São José do Rio Preto, 15090-000, Brazil

  • Gabrail Cancer Center

    Canton, Ohio, 44718, United States

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Gemeinschaftskrankenhaus Havelhöhe gGmbH

    Berlin, 14089, Germany

  • Greater Poland Center of Pulmonology and Thoracic Surgery

    Poznan, 60-569, Poland

  • Guangdong Provincial People's Hospital

    Guangzhou, 510080, China

  • Guy's Hospital

    London, SE1 9RT, United Kingdom

  • HOP Civil

    Strasbourg, 67091, France

  • HOP Nord

    Marseille, 13015, France

  • HOP Pontchaillou

    Rennes, 35000, France

  • HOP Tenon

    Paris, 75020, France

  • Hakodate Goryoukaku Hospital

    Hokkaido, Hakodate, 040-8611, Japan

  • Harbin Medical University Cancer Hospital

    Harbin, 150081, China

  • Health Pharma Professional Research S.A. de C.V.

    Mexico City, 03100, Mexico

  • Henan Cancer Hospital

    Zhengzhou, 450008, China

  • Hirosaki University Hospital

    Aomori, Hirosaki, 036-8563, Japan

  • Hokkaido Cancer Center

    Hokkaido, Sapporo, 003-0804, Japan

  • Hospital CUF Porto

    Porto, 4100-180, Portugal

  • Hospital CUF Tejo

    Lisbon, 1350-352, Portugal

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Duran i Reynals

    Barcelona, 08908, Spain

  • Hospital General Universitario Gregorio Marañón

    Madrid, 28009, Spain

  • Hospital General Universitario de Alicante

    Alicante, 03010, Spain

  • Hospital Regional Universitario de Málaga

    Málaga, 29010, Spain

  • Hospital Santa Creu i Sant Pau

    Barcelona, 08026, Spain

  • Hospital Sao Lucas da PUCRS

    Porto Alegre, 90610-000, Brazil

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Ramon Y Cajal

    Madrid, 28034, Spain

  • Hospital Virgen del Rocío

    Seville, 41013, Spain

  • Hospital de Basurto

    Bilbao, 48013, Spain

  • Hospital do Cancer de Londrina

    Londrina, 86015-520, Brazil

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Hôpital Larrey - CHU de Toulouse

    Toulouse, 31059, France

  • Hôpital Louis Pradel

    Bron, 69677, France

  • ICESP - Instituto do Cancer do Estado de Sao Paulo

    São Paulo, 01246-000, Brazil

  • INS Curie

    Paris, 75248, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Instituto Medico Especializado Alexander Fleming

    Ciudad Autónoma de Bs As, C1426ANZ, Argentina

  • Instituto Médico de la Fundación Estudios Clínicos

    Rosario, S2000DEJ, Argentina

  • Instituto Nacional de Cancerologia

    México, 14080, Mexico

  • Instituto Oncologico de Cordoba

    Córdoba, X5000, Argentina

  • Istituto Di Candiolo

    Candiolo (TO), 10060, Italy

  • Istituto Nazionale IRCCS Tumori Fondazione Pascale

    Naples, 80131, Italy

  • Istituto Tumori Giovanni Paolo II

    Bari, 70124, Italy

  • Japanese Foundation for Cancer Research

    Tokyo, Koto-ku, 135-8550, Japan

  • Juntendo University Hospital

    Tokyo, Bunkyo-ku, 113-8431, Japan

  • Justus-Liebig Universität Gießen

    Giessen, 35392, Germany

  • Kanagawa Cancer Center

    Kanagawa, Yokohama, 241-8515, Japan

  • Kanazawa University Hospital

    Ishikawa, Kanazawa, 920-8641, Japan

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301, Taiwan

  • Karolinska Universitetssjukhuset Solna

    Stockholm, 171 76, Sweden

  • Komagome Hospital

    Tokyo, Bunkyo-ku, 113-8677, Japan

  • Krems University Hospital

    Krems, 3500, Austria

  • Kyushu University Hospital

    Fukuoka, Fukuoka, 812-8582, Japan

  • Leicester Royal Infirmary

    Leicester, LE1 5WW, United Kingdom

  • MED POLONIA SP Z O O, Clinical Trials Department,Poznan

    Poznan, 60693, Poland

  • Maastricht University Medisch Centrum

    Maastricht, 6229 HX, Netherlands

  • Meir Medical Center

    Kfar Saba, 4428164, Israel

  • Montefiore Medical Center

    The Bronx, New York, 10461, United States

  • National Cancer Center

    Goyang, 10408, South Korea

  • National Cancer Center Hospital

    Tokyo, Chuo-ku, 104-0045, Japan

  • National Cancer Center Hospital East

    Chiba, Kashiwa, 277-8577, Japan

  • National Cancer Centre Singapore

    Singapore, 168583, Singapore

  • National Taiwan University Cancer Center

    Taipei, 106, Taiwan

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • National University Hospital-Singapore-22806

    Singapore, 119228, Singapore

  • Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL)

    Amsterdam, 1066 CX, Netherlands

  • Northwell Health

    Lake Success, New York, 11042, United States

  • OPN Healthcare, Inc.

    Glendale, California, 91203, United States

  • Okayama University Hospital

    Okayama, Okayama, 700-8558, Japan

  • OncoClinicas Rio de Janeiro

    Rio de Janeiro, 22250-040, Brazil

  • Oncology Center-Maria Sklodowska-Curie Institute

    Warsaw, 02-781, Poland

  • Oncology Hematology Associates

    Springfield, Missouri, 65807, United States

  • Osaka International Cancer Institute

    Osaka, Osaka, 541-8567, Japan

  • Oslo Universitetssykehus HF, Radiumhospitalet

    Oslo, 0379, Norway

  • Pan American Center for Oncology Trials, LLC

    Rio Piedras, 00935, Puerto Rico

  • Pioneer Research Center - Bullhead City

    Bullhead City, Arizona, 86442, United States

  • Pius-Hospital, Oldenburg

    Oldenburg, 26121, Germany

  • Polish Mother's Memorial Hospital - Research Institute

    Lodz, 93-338, Poland

  • Precision NextGen Oncology

    Beverly Hills, California, 90212, United States

  • Prince of Wales Hospital-Randwick-66496

    Randwick, New South Wales, 2031, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Princess Margaret Hospital

    Hong Kong, 999077, Hong Kong

  • Queen Elizabeth Hospital-Hong Kong-51727

    Hong Kong, 51727, Hong Kong

  • Queen Mary Hospital

    Hong Kong, 999077, Hong Kong

  • Rabin Medical Center Beilinson

    Petah Tikva, 49100, Israel

  • Rambam Medical Center

    Haifa, 3109601, Israel

  • Regional Medical Oncology Center

    Wilson, North Carolina, 27893, United States

  • Royal North Shore Hospital-St Leonards-20807

    St Leonards, New South Wales, 2065, Australia

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203, United States

  • Sahlgrenska Universitetsjukhuset

    Gothenburg, 413 45, Sweden

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Scripps Green Hospital

    La Jolla, California, 92037, United States

  • Severance Hospital

    Seoul, 03722, South Korea

  • Sharp Memorial Hospital

    San Diego, California, 92123, United States

  • Shikoku Cancer Center

    Ehime, Matsuyama, 791-0280, Japan

  • Shizuoka Cancer Center

    Shizuoka, Sunto-gun, 411-8777, Japan

  • Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine

    Hangzhou, 310016, China

  • Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • St John of God Subiaco Hospital

    Subiaco, Western Australia, 6008, Australia

  • St. Louis Cancer Care, LLP

    Bridgeton, Missouri, 63044, United States

  • St. Marianna University Hospital

    Kanagawa, Kawasaki, 216-8511, Japan

  • Swedish Cancer Institute

    Edmonds, Washington, 98026, United States

  • Swedish Cancer Institute

    Issaquah, Washington, 98029, United States

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • Taizhou Hospital of Zhejiang Province

    Taizhou, 317099, China

  • The Catholic University of Korea, St.Vincent's Hospital

    Suwon, 16247, South Korea

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000, China

  • The First Affiliated Hospital, Zhejiang University

    Hangzhou, 310003, China

  • The Royal Marsden Hospital, London

    London, SW3 6JJ, United Kingdom

  • The Royal Marsden Hospital, Sutton

    Sutton, SM2 5PT, United Kingdom

  • Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg

    Heidelberg, 69126, Germany

  • Tohoku University Hospital

    Miyagi, Sendai, 980-8574, Japan

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, Kyoto, 602-8566, Japan

  • Universitätsklinikum Augsburg

    Augsburg, 86156, Germany

  • Universitätsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • Universitätsklinikum Köln (AöR)

    Cologne, 50937, Germany

  • Universitätsklinikum Tübingen

    Tübingen, 72076, Germany

  • Valkyrie Clinical Trials

    Los Angeles, California, 90067, United States

  • Vestre Viken HF, Drammen Sykehus

    Drammen, N-3004, Norway

  • Virginia Cancer Specialists, PC

    Fairfax, Virginia, 22031, United States

  • Wakayama Medical University Hospital

    Wakayama, Wakayama, 641-8510, Japan

  • West China Hospital, Sichuan University

    Chengdu, 610042, China

  • Western General Hospital

    Edinburgh, EH4 2XU, United Kingdom

  • Wuhan Union Hospital

    Wuhan, 430022, China

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

  • Zhongshan Hospital Affiliated to Fudan University

    Shanghai, 200032, China

Conditions

Explore the condition pages connected to this study.