New pill could outperform chemo for HER2 lung cancer patients
NCT ID NCT06151574
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 19 times
Summary
This study tests a new daily pill, zongertinib, against standard chemotherapy for people with advanced non-small cell lung cancer that has a specific HER2 gene change. About 428 adults who have not had prior treatment for their advanced cancer will be randomly assigned to receive either the pill or standard IV chemo. The main goal is to see if zongertinib can delay cancer growth longer than current therapy.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A. O. Ospedale Circolo Fond. Macchi
Varese, 21100, Italy
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AOU Policlinico Umberto I
Roma, 00161, Italy
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Aichi Cancer Center Hospital
Aichi, Nagoya, 464-8681, Japan
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Asan Medical Center
Seoul, 05505, South Korea
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Associacao Dr. Bartholomeu Tacchini
Bento Gonçalves, 95700-084, Brazil
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Austin Health
Heidelberg, Victoria, 3084, Australia
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Azienda Ospedaliera Unversitaria di Parma
Parma, 43100, Italy
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Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania
Catania, 95123, Italy
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Beijing Cancer Hospital
Beijing, 100142, China
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Bradford Hill- Centro de Investigación Clínica
Recoleta, 8420383, Chile
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Brussels - HOSP Jules Bordet
Anderlecht, 1070, Belgium
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CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia
Santo André, 09060-650, Brazil
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CTR Leon Berard
Lyon, 69373, France
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Cancer Care Specialists
Reno, Nevada, 89511, United States
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Cancer Hospital of Chinese Academy of Medical Science
Beijing, 1000021, China
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Carolina Blood and Cancer Care Associates, PA
Rock Hill, South Carolina, 29732, United States
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Centro Hospitalar Lisboa Norte Hospital Pulido Valente
Lisbon, 1769-001, Portugal
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Centro Oncologico Riojano Integral (CORI)
La Rioja, F5300COE, Argentina
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Chang Gung Memorial Hospital, Linkou
Taoyuan District, 330, Taiwan
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Chung Shan Medical University Hospital
Taichung, 404, Taiwan
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Chungbuk National University Hospital
Cheongiu, 28644, South Korea
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Clearview Cancer Institute
Huntsville, Alabama, 35805, United States
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ClinRé 001-022 (Premier Cancer Care and Infusion Center)
Fresno, California, 93710, United States
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Clinic Floridsdorf
Vienna, 1210, Austria
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Clinica Adventista Belgrano
CABA, 1430, Argentina
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Complejo Hospitalario Universitario A Coruña
A Coruña, 15006, Spain
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FAICIC S de RL de C.V.
Veracruz, 91900, Mexico
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First Affiliated Hospital of Xiamen University
Xiamen, 361003, China
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Fudan University Shanghai Cancer Center
Shanghai, 200032, China
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Fujian Cancer Hospital
Fuzhou, 350014, China
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Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, 15090-000, Brazil
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Gachon University Gil Medical Center
Incheon, 21565, South Korea
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Gemeinschaftskrankenhaus Havelhöhe gGmbH
Berlin, 14089, Germany
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Greater Poland Center of Pulmonology and Thoracic Surgery
Poznan, 60-569, Poland
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Guangdong Provincial People's Hospital
Guangzhou, 510080, China
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Guy's Hospital
London, SE1 9RT, United Kingdom
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HOP Civil
Strasbourg, 67091, France
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HOP Nord
Marseille, 13015, France
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HOP Pontchaillou
Rennes, 35000, France
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HOP Tenon
Paris, 75020, France
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Hakodate Goryoukaku Hospital
Hokkaido, Hakodate, 040-8611, Japan
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Harbin Medical University Cancer Hospital
Harbin, 150081, China
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Health Pharma Professional Research S.A. de C.V.
Mexico City, 03100, Mexico
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Henan Cancer Hospital
Zhengzhou, 450008, China
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Hirosaki University Hospital
Aomori, Hirosaki, 036-8563, Japan
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Hokkaido Cancer Center
Hokkaido, Sapporo, 003-0804, Japan
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Hospital CUF Porto
Porto, 4100-180, Portugal
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Hospital CUF Tejo
Lisbon, 1350-352, Portugal
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Duran i Reynals
Barcelona, 08908, Spain
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Hospital General Universitario Gregorio Marañón
Madrid, 28009, Spain
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Hospital General Universitario de Alicante
Alicante, 03010, Spain
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Hospital Regional Universitario de Málaga
Málaga, 29010, Spain
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Hospital Santa Creu i Sant Pau
Barcelona, 08026, Spain
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Hospital Sao Lucas da PUCRS
Porto Alegre, 90610-000, Brazil
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Ramon Y Cajal
Madrid, 28034, Spain
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Hospital Virgen del Rocío
Seville, 41013, Spain
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Hospital de Basurto
Bilbao, 48013, Spain
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Hospital do Cancer de Londrina
Londrina, 86015-520, Brazil
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Hôpital Larrey - CHU de Toulouse
Toulouse, 31059, France
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Hôpital Louis Pradel
Bron, 69677, France
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ICESP - Instituto do Cancer do Estado de Sao Paulo
São Paulo, 01246-000, Brazil
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INS Curie
Paris, 75248, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Instituto Medico Especializado Alexander Fleming
Ciudad Autónoma de Bs As, C1426ANZ, Argentina
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Instituto Médico de la Fundación Estudios Clínicos
Rosario, S2000DEJ, Argentina
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Instituto Nacional de Cancerologia
México, 14080, Mexico
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Instituto Oncologico de Cordoba
Córdoba, X5000, Argentina
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Istituto Di Candiolo
Candiolo (TO), 10060, Italy
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Istituto Nazionale IRCCS Tumori Fondazione Pascale
Naples, 80131, Italy
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Istituto Tumori Giovanni Paolo II
Bari, 70124, Italy
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Japanese Foundation for Cancer Research
Tokyo, Koto-ku, 135-8550, Japan
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Juntendo University Hospital
Tokyo, Bunkyo-ku, 113-8431, Japan
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Justus-Liebig Universität Gießen
Giessen, 35392, Germany
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Kanagawa Cancer Center
Kanagawa, Yokohama, 241-8515, Japan
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Kanazawa University Hospital
Ishikawa, Kanazawa, 920-8641, Japan
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Kangbuk Samsung Hospital
Seoul, 03181, South Korea
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Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 83301, Taiwan
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Karolinska Universitetssjukhuset Solna
Stockholm, 171 76, Sweden
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Komagome Hospital
Tokyo, Bunkyo-ku, 113-8677, Japan
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Krems University Hospital
Krems, 3500, Austria
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Kyushu University Hospital
Fukuoka, Fukuoka, 812-8582, Japan
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Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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MED POLONIA SP Z O O, Clinical Trials Department,Poznan
Poznan, 60693, Poland
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Maastricht University Medisch Centrum
Maastricht, 6229 HX, Netherlands
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Meir Medical Center
Kfar Saba, 4428164, Israel
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Montefiore Medical Center
The Bronx, New York, 10461, United States
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National Cancer Center
Goyang, 10408, South Korea
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National Cancer Center Hospital
Tokyo, Chuo-ku, 104-0045, Japan
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National Cancer Center Hospital East
Chiba, Kashiwa, 277-8577, Japan
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National Cancer Centre Singapore
Singapore, 168583, Singapore
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National Taiwan University Cancer Center
Taipei, 106, Taiwan
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National Taiwan University Hospital
Taipei, 100, Taiwan
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National University Hospital-Singapore-22806
Singapore, 119228, Singapore
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Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL)
Amsterdam, 1066 CX, Netherlands
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Northwell Health
Lake Success, New York, 11042, United States
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OPN Healthcare, Inc.
Glendale, California, 91203, United States
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Okayama University Hospital
Okayama, Okayama, 700-8558, Japan
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OncoClinicas Rio de Janeiro
Rio de Janeiro, 22250-040, Brazil
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Oncology Center-Maria Sklodowska-Curie Institute
Warsaw, 02-781, Poland
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Oncology Hematology Associates
Springfield, Missouri, 65807, United States
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Osaka International Cancer Institute
Osaka, Osaka, 541-8567, Japan
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Oslo Universitetssykehus HF, Radiumhospitalet
Oslo, 0379, Norway
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Pan American Center for Oncology Trials, LLC
Rio Piedras, 00935, Puerto Rico
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Pioneer Research Center - Bullhead City
Bullhead City, Arizona, 86442, United States
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Pius-Hospital, Oldenburg
Oldenburg, 26121, Germany
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Polish Mother's Memorial Hospital - Research Institute
Lodz, 93-338, Poland
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Precision NextGen Oncology
Beverly Hills, California, 90212, United States
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Prince of Wales Hospital-Randwick-66496
Randwick, New South Wales, 2031, Australia
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Princess Margaret Hospital
Hong Kong, 999077, Hong Kong
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Queen Elizabeth Hospital-Hong Kong-51727
Hong Kong, 51727, Hong Kong
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Queen Mary Hospital
Hong Kong, 999077, Hong Kong
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Rabin Medical Center Beilinson
Petah Tikva, 49100, Israel
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Rambam Medical Center
Haifa, 3109601, Israel
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Regional Medical Oncology Center
Wilson, North Carolina, 27893, United States
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Royal North Shore Hospital-St Leonards-20807
St Leonards, New South Wales, 2065, Australia
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SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
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Sahlgrenska Universitetsjukhuset
Gothenburg, 413 45, Sweden
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Samsung Medical Center
Seoul, 06351, South Korea
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Scripps Green Hospital
La Jolla, California, 92037, United States
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Severance Hospital
Seoul, 03722, South Korea
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Sharp Memorial Hospital
San Diego, California, 92123, United States
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Shikoku Cancer Center
Ehime, Matsuyama, 791-0280, Japan
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Shizuoka Cancer Center
Shizuoka, Sunto-gun, 411-8777, Japan
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Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
Hangzhou, 310016, China
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Sourasky Medical Center
Tel Aviv, 6423906, Israel
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St John of God Subiaco Hospital
Subiaco, Western Australia, 6008, Australia
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St. Louis Cancer Care, LLP
Bridgeton, Missouri, 63044, United States
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St. Marianna University Hospital
Kanagawa, Kawasaki, 216-8511, Japan
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Swedish Cancer Institute
Edmonds, Washington, 98026, United States
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Swedish Cancer Institute
Issaquah, Washington, 98029, United States
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Swedish Cancer Institute
Seattle, Washington, 98104, United States
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Taizhou Hospital of Zhejiang Province
Taizhou, 317099, China
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The Catholic University of Korea, St.Vincent's Hospital
Suwon, 16247, South Korea
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000, China
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The First Affiliated Hospital, Zhejiang University
Hangzhou, 310003, China
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The Royal Marsden Hospital, London
London, SW3 6JJ, United Kingdom
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The Royal Marsden Hospital, Sutton
Sutton, SM2 5PT, United Kingdom
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Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg
Heidelberg, 69126, Germany
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Tohoku University Hospital
Miyagi, Sendai, 980-8574, Japan
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UZ Leuven
Leuven, 3000, Belgium
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Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
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University Hospital Kyoto Prefectural University of Medicine
Kyoto, Kyoto, 602-8566, Japan
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Universitätsklinikum Augsburg
Augsburg, 86156, Germany
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Universitätsklinikum Carl Gustav Carus Dresden
Dresden, 01307, Germany
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Universitätsklinikum Köln (AöR)
Cologne, 50937, Germany
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Universitätsklinikum Tübingen
Tübingen, 72076, Germany
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Valkyrie Clinical Trials
Los Angeles, California, 90067, United States
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Vestre Viken HF, Drammen Sykehus
Drammen, N-3004, Norway
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Virginia Cancer Specialists, PC
Fairfax, Virginia, 22031, United States
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Wakayama Medical University Hospital
Wakayama, Wakayama, 641-8510, Japan
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West China Hospital, Sichuan University
Chengdu, 610042, China
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Western General Hospital
Edinburgh, EH4 2XU, United Kingdom
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Wuhan Union Hospital
Wuhan, 430022, China
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Zhejiang Cancer Hospital
Hangzhou, 310022, China
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Zhongshan Hospital Affiliated to Fudan University
Shanghai, 200032, China
Conditions
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