Triple therapy shows promise in Hard-to-Treat stomach cancer

NCT ID NCT06901531

Recruiting now Disease control Sponsor: Astellas Pharma Global Development, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 29 times

Summary

This study tests whether adding zolbetuximab to standard immunotherapy (pembrolizumab) and chemotherapy helps people with advanced stomach or gastroesophageal junction cancer live longer. The trial enrolls 500 adults whose tumors have specific proteins (CLDN18.2 and PD-L1) but lack HER2. Participants receive either the drug combo or a placebo plus chemo and immunotherapy, and are followed for survival and side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AU61001
RECRUITING

Fitzroy, Australia
AU61002
RECRUITING

Kogarah, New South Wales, Australia
AU61003
RECRUITING

Clayton, Victoria, Australia
AU61004
RECRUITING

Brisbane, Queensland, Australia
Affiliated Hospital of Hebei University
RECRUITING

Baoding, 71000, China
Anhui Provincial Cancer Hospital
RECRUITING

Hefei, Anhui, 230031, China
BE32001
RECRUITING

Brussels, Belgium
BE32002
RECRUITING

Bonheiden, Belgium
BE32003
RECRUITING

Ghent, Belgium
BE32004
RECRUITING

Liège, Belgium
BE32006
RECRUITING

Edegem, Belgium
Barbara Ann Karmanos Cancer Center
RECRUITING

Detroit, Michigan, 48201, United States
CZ42003
RECRUITING

Prague, Czechia
CZ42004
RECRUITING

Prague, Czechia
CZ42006
RECRUITING

Brno, Czechia
Chiba Cancer Center
RECRUITING

Chiba, Chiba, Japan
DE49001
RECRUITING

Mainz, Germany
DE49002
RECRUITING

Saarbrücken, Germany
DE49007
RECRUITING

Hanover, Germany
DE49011
RECRUITING

Schweinfurt, Germany
DE49013
RECRUITING

Berlin, Germany
DE49016
RECRUITING

Wolfsburg, Germany
Dana Farber/Harvard Cancer Center
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Medical Center - Duke Cancer Centre
RECRUITING

Durham, North Carolina, 27710, United States
ES34002
RECRUITING

Navarra, Pamplona, Spain
ES34003
RECRUITING

Madrid, Spain
ES34004
RECRUITING

Valencia, Spain
ES34005
RECRUITING

A Coruña, Spain
ES34006
RECRUITING

Barcelona, Spain
ES34007
RECRUITING

Valencia, Spain
ES34008
RECRUITING

Madrid, Spain
ES34009
RECRUITING

Barcelona, Spain
ES34010
RECRUITING

Barcelona, Spain
ES34011
RECRUITING

Barcelona, Spain
ES34012
RECRUITING

Seville, Spain
ES34013
RECRUITING

Pozuelo de Alarcón, Spain
ES34014
RECRUITING

Lleida, Spain
ES34015
RECRUITING

Zaragoza, Spain
ES34016
RECRUITING

Madrid, Spain
ES34017
RECRUITING

Madrid, Spain
ES34019
RECRUITING

Madrid, Madrid, Spain
ES34021
RECRUITING

El Palmar, Spain
ES34022
RECRUITING

Elche, Alicante, Spain
ES34023
RECRUITING

San Cugat Del Valles Barcelona, Cataluyna, Spain
ES34024
RECRUITING

Barcelona, Spain
ES34025
RECRUITING

Seville, Spain
ES34026
RECRUITING

Barcelona, Spain
ES34027
RECRUITING

Madrid, Madrid, Spain
ES34029
RECRUITING

Santiago de Compostela, Spain
ES34030
RECRUITING

Murcia, Spain
FR-33008
RECRUITING

Brest, France
FR33002
RECRUITING

Lille, France
FR33003
RECRUITING

Paris, France
FR33004
RECRUITING

Poitiers, France
FR33005
RECRUITING

Dijon, France
FR33006
RECRUITING

Rouen, France
FR33007
RECRUITING

Lille, France
FR33009
RECRUITING

Carassonne, France
FR33010
RECRUITING

Paris, France
FR33011
RECRUITING

Strasbourg, France
FR33012
RECRUITING

Caen, France
FR33013
RECRUITING

Paris, France
FR33014
RECRUITING

Lyon, France
FR33015
RECRUITING

Plérin, France
FR33016
RECRUITING

Bordeaux, France
FR33017
RECRUITING

Lyon, France
FR33018
RECRUITING

Nice, France
FR33019
RECRUITING

Saint Herbian Cedex, France
FR33020
RECRUITING

Montpellier, France
Franciscan Health Oncology and Hematology Specialists
RECRUITING

Indianapolis, Indiana, 46237, United States
Fujian Provincial Hospital - Department of Medical Oncology
RECRUITING

Fuzhou, Fujian, China
GB-44005
RECRUITING

London, United Kingdom
GB44002
RECRUITING

Coventry, United Kingdom
GB44004
RECRUITING

Glasgow, United Kingdom
GB44010
RECRUITING

Cottingham, East Riding Of Yorkshire, United Kingdom
Gunma University Hospital
RECRUITING

Maebashi, Gunma, Japan
Harbin Medical University Cancer Hospital - Oncology
RECRUITING

Harbin, Heilongjiang, China
Hartford HealthCare - Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
Henan Cancer Hospital - Oncology
RECRUITING

Zhenngzhou, Henan, China
Henry Ford Cancer Institute-Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48201, United States
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, Japan
Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
Houston Methodist Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Hubei Cancer Hospital - Oncology
RECRUITING

Wuhan, Hubei, 430079, China
Hyogo Cancer Center
RECRUITING

Akashi-shi, Hyōgo, Japan
IT-39015
RECRUITING

Pisa, Italy
IT-39020
RECRUITING

Milan, Italy
IT39001
RECRUITING

Rome, Italy
IT39002
RECRUITING

Verona, Italy
IT39003
RECRUITING

Torrette Di Ancona, Italy
IT39004
RECRUITING

Reggio Emilia, Italy
IT39006
RECRUITING

Cermona, Italy
IT39007
RECRUITING

Meldola, Italy
IT39009
RECRUITING

Brescia, Italy
IT39011
RECRUITING

Florence, Italy
IT39012
RECRUITING

Milan, Italy
IT39014
RECRUITING

Candiolo, Italy
IT39016
RECRUITING

Roma, Italy
IT39017
RECRUITING

Bologna, Italy
IT39018
RECRUITING

Milan, Italy
IT39019
RECRUITING

Bergamo, Italy
IT39021
RECRUITING

Naples, Italy
IT39022
RECRUITING

Udine, Italy
KR82001
RECRUITING

Seoul, South Korea
KR82002
RECRUITING

Seoul, South Korea
KR82003
RECRUITING

Seocho-gu, Seoul, South Korea
KR82004
RECRUITING

Daegu, South Korea
KR82005
RECRUITING

Incheon, South Korea
KR82006
RECRUITING

Seoul, South Korea
KR82007
RECRUITING

Seongnam-si, Gyeonggi-do, South Korea
KR82008
RECRUITING

Seoul, South Korea
KR82009
RECRUITING

Cheongju-si, North Chungcheong, South Korea
KR82010
RECRUITING

Seoul, South Korea
KR82011
RECRUITING

Goyang-si, Gyeonggi-do, South Korea
KR82012
RECRUITING

Seoul, South Korea
KR82013
RECRUITING

Suwon, Gyeonggi-do, South Korea
KR82014
RECRUITING

Hwasungun, Joellanamdo, South Korea
KR82015
RECRUITING

Suwon, Gyeonggi-do, South Korea
Kagawa University Hospital
RECRUITING

Kida-gun, Kagawa-ken, Japan
Kanagawa Cancer Ctr Hospital
RECRUITING

Yokohama, Kanagawa, Japan
Kobe City Medical Center General Hospital
RECRUITING

Kobe, Hyōgo, Japan
Kyushu University Hospital (Hematology, Oncology & Cardiovascular medicine)
RECRUITING

Fukuoka, Fukuoka, Japan
Kyushu University Hospital(Gastrointestinal Surgery)
RECRUITING

Fukuoka, Fukuoka, Japan
LT37001
RECRUITING

Kaunas, Lithuania
LT37002
RECRUITING

Vilnius, Lithuania
Metro Minnesota Community Oncology Research Consortium (MMCORC)
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
NL-31002
RECRUITING

Leeuwarden, Netherlands
NL31001
RECRUITING

Nijmegen, Netherlands
NYU Langone Medical Center
RECRUITING

New York, New York, 10016, United States
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, Japan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, Fukuoka, Japan
National Hospital Organization Shikoku Cancer Center
RECRUITING

Matsuyama, Ehime, Japan
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Oncology Hematology West PC dba Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
Osaka General Medical Center
RECRUITING

Osaka, Osaka, Japan
Osaka International Cancer Institute
RECRUITING

Osaka, Osaka, Japan
Osaka University Hospital
RECRUITING

Suita-shi, Osaka, Japan
PL48001
RECRUITING

Brzozów, Woj Podkarpackie, Poland
PL48002
RECRUITING

Przemyśl, Poland
PL48004
RECRUITING

Warsaw, Masovian Voivodeship, Poland
PL48005
RECRUITING

Lubin, Lubusz Voivodeship, Poland
PL48007
RECRUITING

Warsaw, Poland
PL48008
RECRUITING

Olsztyn, Poland
PL48009
RECRUITING

Swidnica, Poland
PT35103
RECRUITING

Braga, Portugal
PT35104
RECRUITING

Guimarães, Portugal
PT35105
RECRUITING

Porto, Portugal
PT35106
RECRUITING

Almada, Portugal
PT35108
RECRUITING

Porto, Portugal
PT35109
RECRUITING

Porto, Portugal
Peking Union Medical College Hospital - Dongdan Campus
RECRUITING

Beijing, China
Piedmont Physician Medical Oncology Atlanta
RECRUITING

Atlanta, Georgia, 30318, United States
Qinghai University Affiliated Hospital
RECRUITING

Xining, Qinghai, China
RO40001
RECRUITING

Cluj-Napoca, Romania
RO40002
RECRUITING

Floreşti, Romania
RO40003
RECRUITING

Craiova, Romania
RO40004
RECRUITING

Timișoara, Romania
RO40005
RECRUITING

Cluj-Napoca, Romania
RO40006
RECRUITING

Cluj-Napoca, Romania
RO40007
RECRUITING

Iași, Romania
RO40008
RECRUITING

Bucharest, Romania
Renji Hospital Shanghai Jiaotong Univ School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200127, China
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Ruijin Hospital of Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, China
Saint Elizabeth Medical Center Edgewood
RECRUITING

Edgewood, Kentucky, 41017, United States
Saitama Cancer Center
RECRUITING

Kitaadachi-gun Ina-machi, Saitama, Japan
Saitama Medical University International Medical Center
RECRUITING

Hidaka-shi, Saitama, Japan
Shizuoka Cancer Center
RECRUITING

Sunto-gun, Shizuoka, Japan
Sichuan Cancer Hospital
RECRUITING

Chengdu, Sichuan, 610200, China
Site BE32005
RECRUITING

Leuven, Belgium
Site BR55001
RECRUITING

São José do Rio Preto, Brazil
Site BR55003
RECRUITING

Porto Alegre, Brazil
Site BR55004
RECRUITING

Lages, Brazil
Site BR55006
RECRUITING

São Caetano do Sul, Brazil
Site BR55008
RECRUITING

Jaú, Brazil
Site BR55014
RECRUITING

Belo Horizonte, Brazil
Site DE49004
RECRUITING

Leipzig, Germany
Site DE49010
RECRUITING

Essen, Germany
Site ES34018
RECRUITING

Zaragoza, Spain
Site ES34031
RECRUITING

Madrid, Spain
Site GB44003
RECRUITING

Cardiff, United Kingdom
Site MX52001
RECRUITING

Oaxaca City, Mexico
Site MX52003
RECRUITING

Mexico City, Mexico
Site PT35102
RECRUITING

Lisbon, Portugal
Site PT35107
RECRUITING

Lisbon, Portugal
Site TR90006
RECRUITING

Ankara, Turkey (Türkiye)
Site TR90013
RECRUITING

Konya, Turkey (Türkiye)
Site TR90015
RECRUITING

Van, Turkey (Türkiye)
St. Marianna University Hospital
RECRUITING

Kawasaki-shi, Kanagawa, Japan
Sun Yat-sen University - Cancer Center
RECRUITING

Guangzhou, Guangdong, 510060, China
Sun Yat-sen University - Cancer Center
RECRUITING

Guangzhou, Guangdong, 510555, China
TOI Clinical Research
RECRUITING

Cerritos, California, 90703, United States
TR90004
RECRUITING

Ankara, Turkey (Türkiye)
TW-88603
RECRUITING

Dawan, Taiwan, Taiwan
TW88601
RECRUITING

Taichung, Taiwan
TW88604
RECRUITING

Kaohsiung City, Taiwan
TW88605
RECRUITING

Taipei, Taiwan
TW88606
RECRUITING

Tainan, Taiwan
Texas Oncology-Baylor Charles A Sammons Cancer Center
RECRUITING

Dallas, Texas, 75246, United States
The Angeles Clinic and Research Institute, West Los Angeles Office
RECRUITING

Los Angeles, California, 90025, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, Japan
The Center For Cancer And Blood Disorders (Texas Cancer Care)
RECRUITING

Fort Worth, Texas, 76104, United States
The First Affiliated Hospital of Zhejiang University
RECRUITING

Hangzhou, Zhejiang, China
The University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States
Tianjin Medical University General Hospital
RECRUITING

Tianjin, Tianjin Municipality, China
Tohoku University Hospital
RECRUITING

Sendai, Miyagi, Japan
UAB Medicine - UAB Hospital
RECRUITING

Birmingham, Alabama, 35294, United States
UK44001
RECRUITING

Bristol, United Kingdom
UK44006
RECRUITING

Dundee, United Kingdom
UK44009
RECRUITING

Manchester, United Kingdom
UK44011
RECRUITING

London, United Kingdom
UK44014
RECRUITING

London, United Kingdom
UK44015
RECRUITING

London, United Kingdom
UK44016
RECRUITING

London, United Kingdom
University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Maryland Medical System - University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21021, United States
University of Michigan Health System
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68105, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
Utah Cancer Specialists Cancer Center - Medical Oncology
RECRUITING

Salt Lake City, Utah, 84106, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED UNRESECTABLE GASTRIC ADENOCARCINOMA OR CANCER LOCALLY ADVANCED UNRESECTABLE GASTROESOPHAGEAL JUNCTION (GEJ) ADENOCARCINOMA OR CANCER METASTATIC GASTRIC ADENOCARCINOMA OR CANCER METASTATIC GASTROESOPHAGEAL JUNCTION (GEJ) ADENOCARCINOMA