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New injection aims to tame Ultra-High cholesterol in rare genetic disorder

NCT ID NCT07037771

Recruiting now Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing an experimental injection called zodasiran to see if it can safely and effectively lower very high 'bad' cholesterol (LDL-C) in people with a rare, severe genetic condition called homozygous familial hypercholesterolemia (HoFH). It will involve about 60 participants aged 12 and older who are already on standard cholesterol medications. For one year, some will receive the new injection and others a placebo, followed by an option for everyone to try the active drug.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Research Site 1

    RECRUITING

    Cincinnati, Ohio, 45227, United States

  • Research Site 10

    RECRUITING

    Jerusalem, 9112001, Israel

  • Research Site 11

    RECRUITING

    Parktown, Johannesburg, 2193, South Africa

  • Research Site 12

    RECRUITING

    Christchurch, 8011, New Zealand

  • Research Site 13

    RECRUITING

    Camperdown, New South Wales, 2050, Australia

  • Research Site 14

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

  • Research Site 15

    RECRUITING

    Tel Litwinsky, 5265601, Israel

  • Research Site 16

    RECRUITING

    Okayama, Okayama-ken, 700-8558, Japan

  • Research Site 17

    RECRUITING

    Tbilisi, 0159, Georgia

  • Research Site 18

    RECRUITING

    Tbilisi, 160, Georgia

  • Research Site 19

    RECRUITING

    Tbilisi, 186, Georgia

  • Research Site 2

    RECRUITING

    New York, New York, 10029, United States

  • Research Site 20

    RECRUITING

    Fukushima, 960-1295, Japan

  • Research Site 21

    RECRUITING

    Heidelberg, Victoria, 3084, Australia

  • Research Site 22

    RECRUITING

    Saitama, 350-0495, Japan

  • Research Site 3

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Research Site 4

    RECRUITING

    Québec, Quebec, G1V 4W2, Canada

  • Research Site 5

    RECRUITING

    Vancouver, British Columbia, V6Z 2H2, Canada

  • Research Site 6

    RECRUITING

    Chicoutimi, Quebec, G7H 7K9, Canada

  • Research Site 7

    RECRUITING

    Park Ridge, Illinois, 60068, United States

  • Research Site 8

    RECRUITING

    Cape Town, 7925, South Africa

  • Research Site 9

    RECRUITING

    Saint Leonards, New South Wales, 2065, Australia

Conditions

Explore the condition pages connected to this study.

HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA