Major heart study tests new shot to slash heart attack and stroke risk

NCT ID NCT07181109

Recruiting now Disease control Sponsor: Alnylam Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether adding a new investigational drug called zilebesiran to standard blood pressure medications can lower the risk of serious heart problems like heart attack, stroke, or heart failure. It will involve about 11,000 adults with high blood pressure that isn't fully controlled and who are at high risk for heart disease. Participants will receive either zilebesiran or a placebo (a dummy shot) in addition to their usual care to see which group has fewer heart-related events.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Clinical Trial Site
NOT_YET_RECRUITING

Huntsville, Alabama, 35801, United States
Clinical Trial Site
RECRUITING

Huntsville, Alabama, 35805, United States
Clinical Trial Site
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Sheffield, Alabama, 35660, United States
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NOT_YET_RECRUITING

Chandler, Arizona, 85224, United States
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Gilbert, Arizona, 85296, United States
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NOT_YET_RECRUITING

Glendale, Arizona, 85308, United States
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NOT_YET_RECRUITING

Mesa, Arizona, 85213, United States
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Phoenix, Arizona, 85015, United States
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Phoenix, Arizona, 85020, United States
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Sun City West, Arizona, 85375, United States
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Tucson, Arizona, 85741, United States
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NOT_YET_RECRUITING

Tucson, Arizona, 85741, United States
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Little Rock, Arkansas, 72204, United States
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Little Rock, Arkansas, 72205, United States
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NOT_YET_RECRUITING

Beverly Hills, California, 90211, United States
Clinical Trial Site
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Chula Vista, California, 91910, United States
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Escondido, California, 92025, United States
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Glendale, California, 91206, United States
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NOT_YET_RECRUITING

Lancaster, California, 93534, United States
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Long Beach, California, 90815, United States
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Lynwood, California, 90262, United States
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NOT_YET_RECRUITING

Newhall, California, 91321, United States
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Northridge, California, 91325, United States
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Pasadena, California, 91105, United States
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NOT_YET_RECRUITING

San Diego, California, 92111, United States
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San Dimas, California, 91773, United States
Clinical Trial Site
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Tarzana, California, 91356, United States
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Toluca Lake, California, 91602, United States
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Vista, California, 92081, United States
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Walnut Creek, California, 94598, United States
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Boca Raton, Florida, 33434, United States
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Brandon, Florida, 33511, United States
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NOT_YET_RECRUITING

Fleming Island, Florida, 32003, United States
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Hialeah, Florida, 33012, United States
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Hollywood, Florida, 33024, United States
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Jacksonville, Florida, 32205, United States
Clinical Trial Site
NOT_YET_RECRUITING

Jacksonville, Florida, 32216, United States
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Jacksonville, Florida, 32216, United States
Clinical Trial Site
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Leesburg, Florida, 34748, United States
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Melbourne, Florida, 32934, United States
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Miami, Florida, 33134, United States
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Miami, Florida, 33135, United States
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Miami, Florida, 33186, United States
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Orlando, Florida, 32825, United States
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Palm Springs, Florida, 33406, United States
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Tampa, Florida, 33615, United States
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Wellington, Florida, 33449, United States
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Brunswick, Georgia, 31520, United States
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NOT_YET_RECRUITING

Columbus, Georgia, 31904, United States
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Conyers, Georgia, 30012, United States
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Conyers, Georgia, 30094, United States
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Fayetteville, Georgia, 30214, United States
Clinical Trial Site
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Johns Creek, Georgia, 30024, United States
Clinical Trial Site
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Lawrenceville, Georgia, 30044, United States
Clinical Trial Site
NOT_YET_RECRUITING

Suwanee, Georgia, 30024, United States
Clinical Trial Site
NOT_YET_RECRUITING

Thomasville, Georgia, 31792, United States
Clinical Trial Site
RECRUITING

Hazel Crest, Illinois, 60429, United States
Clinical Trial Site
NOT_YET_RECRUITING

Oak Brook, Illinois, 60523, United States
Clinical Trial Site
RECRUITING

Orland Park, Illinois, 60462, United States
Clinical Trial Site
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Tinley Park, Illinois, 60477, United States
Clinical Trial Site
NOT_YET_RECRUITING

Avon, Indiana, 46123, United States
Clinical Trial Site
RECRUITING

Evansville, Indiana, 47714, United States
Clinical Trial Site
NOT_YET_RECRUITING

Greenfield, Indiana, 46140, United States
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South Bend, Indiana, 46617, United States
Clinical Trial Site
RECRUITING

Valparaiso, Indiana, 46383, United States
Clinical Trial Site
NOT_YET_RECRUITING

Hutchinson, Kansas, 67502, United States
Clinical Trial Site
RECRUITING

Topeka, Kansas, 66606, United States
Clinical Trial Site
RECRUITING

Wichita, Kansas, 67214, United States
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NOT_YET_RECRUITING

Wichita, Kansas, 67218, United States
Clinical Trial Site
RECRUITING

Lexington, Kentucky, 40503, United States
Clinical Trial Site
NOT_YET_RECRUITING

Hammond, Louisiana, 70403, United States
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Lafayette, Louisiana, 70503, United States
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Opelousas, Louisiana, 70570, United States
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Shreveport, Louisiana, 71105, United States
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Zachary, Louisiana, 70791, United States
Clinical Trial Site
NOT_YET_RECRUITING

Baltimore, Maryland, 21215, United States
Clinical Trial Site
NOT_YET_RECRUITING

Baltimore, Maryland, 21229, United States
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RECRUITING

Beltsville, Maryland, 20705, United States
Clinical Trial Site
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Bowie, Maryland, 20715, United States
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Lanham, Maryland, 20706, United States
Clinical Trial Site
NOT_YET_RECRUITING

Rockville, Maryland, 20850, United States
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Flint, Michigan, 48504, United States
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Southfield, Michigan, 48075, United States
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Troy, Michigan, 48085, United States
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NOT_YET_RECRUITING

Troy, Michigan, 48098, United States
Clinical Trial Site
NOT_YET_RECRUITING

Richfield, Minnesota, 55423, United States
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NOT_YET_RECRUITING

Jackson, Mississippi, 39216, United States
Clinical Trial Site
RECRUITING

Olive Branch, Mississippi, 38654, United States
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Port Gibson, Mississippi, 39150, United States
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Kansas City, Missouri, 64111, United States
Clinical Trial Site
NOT_YET_RECRUITING

Kansas City, Missouri, 64151, United States
Clinical Trial Site
NOT_YET_RECRUITING

St Louis, Missouri, 63136, United States
Clinical Trial Site
NOT_YET_RECRUITING

St Louis, Missouri, 63141, United States
Clinical Trial Site
NOT_YET_RECRUITING

Fremont, Nebraska, 68025, United States
Clinical Trial Site
RECRUITING

Bridgewater, New Jersey, 08807, United States
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Albuquerque, New Mexico, 87106, United States
Clinical Trial Site
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New Windsor, New York, 12553, United States
Clinical Trial Site
NOT_YET_RECRUITING

North Massapequa, New York, 11758, United States
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RECRUITING

Rosedale, New York, 11422, United States
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RECRUITING

The Bronx, New York, 10461, United States
Clinical Trial Site
NOT_YET_RECRUITING

West Seneca, New York, 14224, United States
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NOT_YET_RECRUITING

Westfield, New York, 14787, United States
Clinical Trial Site
RECRUITING

Durham, North Carolina, 27704, United States
Clinical Trial Site
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Greenville, North Carolina, 27834, United States
Clinical Trial Site
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High Point, North Carolina, 27260, United States
Clinical Trial Site
RECRUITING

Fargo, North Dakota, 58104, United States
Clinical Trial Site
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Beavercreek, Ohio, 45431, United States
Clinical Trial Site
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Cincinnati, Ohio, 45212, United States
Clinical Trial Site
RECRUITING

Cincinnati, Ohio, 45219, United States
Clinical Trial Site
RECRUITING

Columbus, Ohio, 43213, United States
Clinical Trial Site
NOT_YET_RECRUITING

Dayton, Ohio, 45429, United States
Clinical Trial Site
RECRUITING

Lima, Ohio, 45801, United States
Clinical Trial Site
RECRUITING

Maumee, Ohio, 43537, United States
Clinical Trial Site
NOT_YET_RECRUITING

Edmond, Oklahoma, 73013, United States
Clinical Trial Site
NOT_YET_RECRUITING

Moore, Oklahoma, 73160, United States
Clinical Trial Site
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Clinical Trial Site
RECRUITING

Camp Hill, Pennsylvania, 17701, United States
Clinical Trial Site
RECRUITING

Horsham, Pennsylvania, 19044, United States
Clinical Trial Site
NOT_YET_RECRUITING

Media, Pennsylvania, 19063, United States
Clinical Trial Site
RECRUITING

Uniontown, Pennsylvania, 15401, United States
Clinical Trial Site
NOT_YET_RECRUITING

Columbia, South Carolina, 29205, United States
Clinical Trial Site
RECRUITING

Greenville, South Carolina, 29607, United States
Clinical Trial Site
NOT_YET_RECRUITING

Chattanooga, Tennessee, 37404, United States
Clinical Trial Site
RECRUITING

Chattanooga, Tennessee, 37412, United States
Clinical Trial Site
RECRUITING

Knoxville, Tennessee, 37909, United States
Clinical Trial Site
NOT_YET_RECRUITING

Knoxville, Tennessee, 37923, United States
Clinical Trial Site
NOT_YET_RECRUITING

Amarillo, Texas, 79106, United States
Clinical Trial Site
RECRUITING

Arlington, Texas, 76012, United States
Clinical Trial Site
NOT_YET_RECRUITING

Arlington, Texas, 76015, United States
Clinical Trial Site
RECRUITING

Austin, Texas, 78735, United States
Clinical Trial Site
RECRUITING

Beaumont, Texas, 77702, United States
Clinical Trial Site
NOT_YET_RECRUITING

Carrollton, Texas, 75006, United States
Clinical Trial Site
NOT_YET_RECRUITING

Dallas, Texas, 75246, United States
Clinical Trial Site
RECRUITING

Duncanville, Texas, 75137, United States
Clinical Trial Site
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Houston, Texas, 77002, United States
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Houston, Texas, 77024, United States
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Houston, Texas, 77025, United States
Clinical Trial Site
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Houston, Texas, 77036, United States
Clinical Trial Site
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Houston, Texas, 77043, United States
Clinical Trial Site
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Houston, Texas, 77061, United States
Clinical Trial Site
RECRUITING

Houston, Texas, 77070, United States
Clinical Trial Site
NOT_YET_RECRUITING

Houston, Texas, 77095, United States
Clinical Trial Site
NOT_YET_RECRUITING

Humble, Texas, 77338, United States
Clinical Trial Site
RECRUITING

Katy, Texas, 77450, United States
Clinical Trial Site
NOT_YET_RECRUITING

Kingwood, Texas, 77339, United States
Clinical Trial Site
RECRUITING

Laredo, Texas, 78041, United States
Clinical Trial Site
RECRUITING

McAllen, Texas, 78503, United States
Clinical Trial Site
NOT_YET_RECRUITING

McKinney, Texas, 75069, United States
Clinical Trial Site
RECRUITING

McKinney, Texas, 75071, United States
Clinical Trial Site
RECRUITING

Mesquite, Texas, 75149, United States
Clinical Trial Site
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Missouri City, Texas, 77459, United States
Clinical Trial Site
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Paris, Texas, 75462, United States
Clinical Trial Site
RECRUITING

Plano, Texas, 75024, United States
Clinical Trial Site
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Port Arthur, Texas, 77642, United States
Clinical Trial Site
RECRUITING

San Antonio, Texas, 78220, United States
Clinical Trial Site
RECRUITING

San Antonio, Texas, 78229, United States
Clinical Trial Site
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
Clinical Trial Site
RECRUITING

San Antonio, Texas, 78231, United States
Clinical Trial Site
NOT_YET_RECRUITING

Sherman, Texas, 75092, United States
Clinical Trial Site
RECRUITING

Sugar Land, Texas, 77479, United States
Clinical Trial Site
NOT_YET_RECRUITING

Tomball, Texas, 77375, United States
Clinical Trial Site
RECRUITING

Waco, Texas, 76712, United States
Clinical Trial Site
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Bountiful, Utah, 84010, United States
Clinical Trial Site
RECRUITING

Bountiful, Utah, 84025, United States
Clinical Trial Site
RECRUITING

Layton, Utah, 84041, United States
Clinical Trial Site
NOT_YET_RECRUITING

Arlington, Virginia, 22205, United States
Clinical Trial Site
RECRUITING

Danville, Virginia, 24541, United States
Clinical Trial Site
RECRUITING

Newport News, Virginia, 23606, United States
Clinical Trial Site
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Norfolk, Virginia, 23502, United States
Clinical Trial Site
RECRUITING

Richmond, Virginia, 23219, United States
Clinical Trial Site
NOT_YET_RECRUITING

Suffolk, Virginia, 23435, United States
Clinical Trial Site
RECRUITING

Suffolk, Virginia, 23435, United States
Clinical Trial Site
RECRUITING

Winchester, Virginia, 22601, United States
Clinical Trial Site
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Bellevue, Washington, 98007, United States
Clinical Trial Site
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Castle Hill, 2154, Australia
Clinical Trial Site
RECRUITING

Gosford, 2250, Australia
Clinical Trial Site
NOT_YET_RECRUITING

Merewether, 2291, Australia
Clinical Trial Site
NOT_YET_RECRUITING

Southport, 4217, Australia
Clinical Trial Site
RECRUITING

Waitara, 2077, Australia
Clinical Trial Site
RECRUITING

Brampton, L6Z 4N5, Canada
Clinical Trial Site
NOT_YET_RECRUITING

Cambridge, N1R 7R1, Canada
Clinical Trial Site
RECRUITING

Etobicoke, M9R 4E1, Canada
Clinical Trial Site
NOT_YET_RECRUITING

Greenfield Park, J4V 2G8, Canada
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RECRUITING

Lévis, G6W 0M5, Canada
Clinical Trial Site
RECRUITING

Mirabel, J7J 2K8, Canada
Clinical Trial Site
NOT_YET_RECRUITING

Mississauga, L5K 2L3, Canada
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RECRUITING

Moncton, E1G 5C4, Canada
Clinical Trial Site
RECRUITING

Scarborough, M1B 4Z8, Canada
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NOT_YET_RECRUITING

Toronto, M6N 1B5, Canada
Clinical Trial Site
NOT_YET_RECRUITING

Chikushino-shi, 818-0058, Japan
Clinical Trial Site
RECRUITING

Chūōku, 103-0027, Japan
Clinical Trial Site
RECRUITING

Chūōku, 810-0066, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Fukuoka, 812-8582, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Fukuoka, 814-0180, Japan
Clinical Trial Site
RECRUITING

Hachiōji, 193-0811, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Hakodate-Shi, 041-0821, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Himeji, 670-8560, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Izumi, 594-0073, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Kasuga, 816-0864, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Kita-ku, 530-0052, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Kusatsu, 525-8585, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Minamiku, 861-4193, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Minato, 108-0073, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Nagasaki, 850-0842, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Osaka, 530-0005, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Osaka, 530-0012, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Saku, 385-0051, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Sapporo, 062-8618, Japan
Clinical Trial Site
RECRUITING

Shinagawa-Ku, 140-8522, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Tamanashi, 865-0016, Japan
Clinical Trial Site
RECRUITING

Yokosuka, 239-8567, Japan
Clinical Trial Site
NOT_YET_RECRUITING

Ebdentown, 5018, New Zealand
Clinical Trial Site
RECRUITING

Hamilton, 3243, New Zealand
Clinical Trial Site
RECRUITING

Silverdale, 0932, New Zealand
Clinical Trial Site
NOT_YET_RECRUITING

Birmingham, B15 2SQ, United Kingdom
Clinical Trial Site
RECRUITING

Birmingham, B21 9RY, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Bury St Edmunds, IP33 2QZ, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Cardiff, CF5 4AD, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Chichester, PO19 6SE, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Corby, NN17 2UR, United Kingdom
Clinical Trial Site
RECRUITING

Glasgow, G20 7BE, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Ilford, IG1 4HP, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Leeds, LS26 9AA, United Kingdom
Clinical Trial Site
RECRUITING

Liverpool, L24 7RB, United Kingdom
Clinical Trial Site
RECRUITING

London, EC1A 7BE, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Manchester, M27 8FF, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Penzance, TR18 3DX, United Kingdom
Clinical Trial Site
NOT_YET_RECRUITING

Poole, BH16 5PW, United Kingdom
Clinical Trial Site
RECRUITING

Teeside, TS19 8PE, United Kingdom

Conditions

Explore the condition pages connected to this study.

HIGH CARDIOVASCULAR RISK HIGH RISK CARDIOVASCULAR DISEASE HYPERTENSION