New drug tested to tame Tough-to-Treat high blood pressure

NCT ID NCT06272487

Completed Disease control Sponsor: Alnylam Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study tested an investigational drug called zilebesiran in adults with high cardiovascular risk and high blood pressure that was not well-controlled despite taking standard medications. The goal was to see if adding zilebesiran could safely lower blood pressure more effectively. Researchers measured changes in blood pressure over 6 months in 375 participants.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Clinical Trial Site

Alexander City, Alabama, 35010, United States
Clinical Trial Site

Daphne, Alabama, 36526, United States
Clinical Trial Site

Foley, Alabama, 36535, United States
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Huntsville, Alabama, 35801, United States
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Huntsville, Alabama, 35805, United States
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Montgomery, Alabama, 36117, United States
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Gilbert, Arizona, 85297, United States
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Phoenix, Arizona, 85028, United States
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Sun City, Arizona, 85351, United States
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Tempe, Arizona, 85281, United States
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Tucson, Arizona, 85741, United States
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Beverly Hills, California, 90211, United States
Clinical Trial Site

Covina, California, 91723, United States
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Encinitas, California, 92024, United States
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Garden Grove, California, 92844, United States
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Huntington Beach, California, 92647, United States
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Los Angeles, California, 90022, United States
Clinical Trial Site

Los Angeles, California, 90057, United States
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Northridge, California, 91324, United States
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Northridge, California, 91325, United States
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Pasadena, California, 91105, United States
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San Diego, California, 92108, United States
Clinical Trial Site

San Diego, California, 92111, United States
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San Dimas, California, 91773, United States
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Simi Valley, California, 93065, United States
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Vacaville, California, 95687, United States
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Van Nuys, California, 91405, United States
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West Hills, California, 91307, United States
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Colorado Springs, Colorado, 80918, United States
Clinical Trial Site

Denver, Colorado, 80210, United States
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Denver, Colorado, 80230, United States
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Hartford, Connecticut, 06112, United States
Clinical Trial Site

Middlebury, Connecticut, 06762, United States
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Waterbury, Connecticut, 06708, United States
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Washington D.C., District of Columbia, 20009, United States
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Clearwater, Florida, 33756, United States
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Coral Gables, Florida, 33134, United States
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Daytona Beach, Florida, 32117, United States
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Fort Myers, Florida, 33912, United States
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Hollywood, Florida, 33021, United States
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Jacksonville, Florida, 32204, United States
Clinical Trial Site

Jacksonville, Florida, 32209, United States
Clinical Trial Site

Jacksonville, Florida, 32256, United States
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Jensen Beach, Florida, 34957, United States
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Lake City, Florida, 32055, United States
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Miami, Florida, 33126, United States
Clinical Trial Site

Miami, Florida, 33135, United States
Clinical Trial Site

Miami, Florida, 33137, United States
Clinical Trial Site

Miami, Florida, 33144, United States
Clinical Trial Site

Miami, Florida, 33155, United States
Clinical Trial Site

Miami, Florida, 33176, United States
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Miramar, Florida, 33027, United States
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Orlando, Florida, 32801, United States
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The Villages, Florida, 32162, United States
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Winter Haven, Florida, 33880, United States
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Acworth, Georgia, 30101, United States
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Atlanta, Georgia, 30322, United States
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Columbus, Georgia, 31904, United States
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Douglasville, Georgia, 30134, United States
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Gainesville, Georgia, 30501, United States
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Savannah, Georgia, 31406, United States
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Thomasville, Georgia, 31792, United States
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Boise, Idaho, 83706, United States
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Chicago, Illinois, 60602, United States
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Elkhart, Indiana, 46514, United States
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Evansville, Indiana, 47714, United States
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Richmond, Indiana, 47374, United States
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El Dorado, Kansas, 67042, United States
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Newton, Kansas, 67114, United States
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Wichita, Kansas, 67207, United States
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Owensboro, Kentucky, 42303, United States
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Monroe, Louisiana, 71201, United States
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New Orleans, Louisiana, 70119, United States
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Boston, Massachusetts, 02114, United States
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West Springfield, Massachusetts, 01089, United States
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Flint, Michigan, 48504, United States
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Shelby, Michigan, 48315, United States
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Ypsilanti, Michigan, 48197, United States
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Minneapolis, Minnesota, 55404, United States
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Richfield, Minnesota, 55423, United States
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Columbus, Mississippi, 39705, United States
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Tupelo, Mississippi, 38801, United States
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Creve Coeur, Missouri, 63141, United States
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Kalispell, Montana, 59901, United States
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Lincoln, Nebraska, 68510, United States
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Omaha, Nebraska, 68114, United States
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Las Vegas, Nevada, 89121, United States
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Portsmouth, New Hampshire, 03801, United States
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Berlin, New Jersey, 08009, United States
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Albuquerque, New Mexico, 87109, United States
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New York, New York, 10017, United States
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Charlotte, North Carolina, 28287, United States
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Durham, North Carolina, 27704, United States
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Durham, North Carolina, 27713, United States
Clinical Trial Site

Greensboro, North Carolina, 27401, United States
Clinical Trial Site

Greenville, North Carolina, 27834, United States
Clinical Trial Site

Monroe, North Carolina, 28112, United States
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Raleigh, North Carolina, 27609, United States
Clinical Trial Site

Wilmington, North Carolina, 28403, United States
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Winston-Salem, North Carolina, 27103, United States
Clinical Trial Site

Cleveland, Ohio, 44106, United States
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Marion, Ohio, 43302, United States
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Norman, Oklahoma, 73072, United States
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Oklahoma City, Oklahoma, 73102, United States
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Bethlehem, Pennsylvania, 18017, United States
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Langhorne, Pennsylvania, 19047, United States
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Newport, Pennsylvania, 17074, United States
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Philadelphia, Pennsylvania, 19114, United States
Clinical Trial Site

East Providence, Rhode Island, 02914, United States
Clinical Trial Site

Myrtle Beach, South Carolina, 29572, United States
Clinical Trial Site

Rapid City, South Dakota, 57701, United States
Clinical Trial Site

Chattanooga, Tennessee, 37404, United States
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Germantown, Tennessee, 38138, United States
Clinical Trial Site

Knoxville, Tennessee, 37909, United States
Clinical Trial Site

Knoxville, Tennessee, 37923, United States
Clinical Trial Site

Memphis, Tennessee, 38119, United States
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Austin, Texas, 78744, United States
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Coppell, Texas, 75019, United States
Clinical Trial Site

Dallas, Texas, 75230, United States
Clinical Trial Site

Dallas, Texas, 75234, United States
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El Paso, Texas, 79925, United States
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El Paso, Texas, 79935, United States
Clinical Trial Site

Houston, Texas, 77002, United States
Clinical Trial Site

Houston, Texas, 77024, United States
Clinical Trial Site

Houston, Texas, 77054, United States
Clinical Trial Site

Houston, Texas, 77081, United States
Clinical Trial Site

Houston, Texas, 77099, United States
Clinical Trial Site

Magnolia, Texas, 77355, United States
Clinical Trial Site

San Antonio, Texas, 78229, United States
Clinical Trial Site

San Antonio, Texas, 78240, United States
Clinical Trial Site

Shenandoah, Texas, 77384, United States
Clinical Trial Site

Sherman, Texas, 75092, United States
Clinical Trial Site

Stephenville, Texas, 76401, United States
Clinical Trial Site

Tomball, Texas, 77375, United States
Clinical Trial Site

Burlington, Vermont, 05401, United States
Clinical Trial Site

Burke, Virginia, 22015, United States
Clinical Trial Site

Manassas, Virginia, 20109, United States
Clinical Trial Site

Norfolk, Virginia, 23504, United States
Clinical Trial Site

West Allis, Wisconsin, 53227, United States
Clinical Trial Site

Blacktown, 2148, Australia
Clinical Trial Site

Brookvale, 2100, Australia
Clinical Trial Site

Bruce, 2617, Australia
Clinical Trial Site

Concord, 2139, Australia
Clinical Trial Site

Garran, 2605, Australia
Clinical Trial Site

Kanwal, 2259, Australia
Clinical Trial Site

Kogarah, 2217, Australia
Clinical Trial Site

Perth, 6000, Australia
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Sippy Downs, 4556, Australia
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St Leonards, 2065, Australia
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Tarragindi, 4121, Australia
Clinical Trial Site

Brampton, L6T 0G1, Canada
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Chicoutimi, G7H 7K9, Canada
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Greenfield Park, J4V 2G8, Canada
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Montreal, H4J 1C5, Canada
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Montreal, H4N 2W2, Canada
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Québec, G1V 4T3, Canada
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Sainte-Foy, G1V 4G5, Canada
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Sarnia, N7T 4X3, Canada
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Toronto, M3J 0K2, Canada
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Toronto, M4P 1E4, Canada
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Toronto, M5B 1W8, Canada
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Trois-Rivières, G9A 4P3, Canada
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Waterloo, N2T 0C1, Canada
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Winnipeg, R2V 3M3, Canada
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Ponce, 00716, Puerto Rico
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Toa Baja, 00949, Puerto Rico
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Basel, 4031, Switzerland
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Geneva, 1205, Switzerland
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Lausanne, 1005, Switzerland
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Lucerne, 6000, Switzerland
Clinical Trial Site

Bellshill, ML4 3NJ, United Kingdom
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Birmingham, B15 2SQ, United Kingdom
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Bristol, BS2 8HW, United Kingdom
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Canterbury, CT1 3NG, United Kingdom
Clinical Trial Site

Cardiff, CF15 9SS, United Kingdom
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Carshalton, SM5 1AA, United Kingdom
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Chesterfield, S40 4AA, United Kingdom
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Chorley, PR7 7NA, United Kingdom
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Fowey, PL23 1DT, United Kingdom
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Glasgow, G20 7BE, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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Hexham, NE46 1QJ, United Kingdom
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Leicester, LE5 4PW, United Kingdom
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Liskeard, PL14 3XA, United Kingdom
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Liverpool, L22 0LG, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SE1 1YR, United Kingdom
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London, SW17 0QT, United Kingdom
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Luton, LU4 0DZ, United Kingdom
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Manchester, M15 6SE, United Kingdom
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Newquay, TR7 1RU, United Kingdom
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Pickering, YO18 8BL, United Kingdom
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Plymouth, PL5 3JB, United Kingdom
Clinical Trial Site

Torpoint, PL11 2TB, United Kingdom

Conditions

Explore the condition pages connected to this study.

HIGH CARDIOVASCULAR RISK HYPERTENSION