New hope for Hard-to-Treat GIST: oral combo trial launches
NCT ID NCT06655246
First seen Sep 30, 2025 · Last updated May 16, 2026 · Updated 27 times
Summary
This study tests a new oral drug, ziftomenib, combined with the standard drug imatinib in adults with advanced gastrointestinal stromal tumors (GIST) that no longer respond to imatinib alone. The goal is to see if the combination is safe and can shrink or stabilize tumors. About 157 participants will take the pills at home and be monitored for side effects and cancer response.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Harvard University
RECRUITINGBoston, Massachusetts, 02215, United States
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21287, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic Cancer Center
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic Cancer Center
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Cancer Center
RECRUITINGRochester, Minnesota, 55905, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Memorial Sloan-Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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Sarah Cannon Research Institute
RECRUITINGDenver, Colorado, 80220, United States
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Sarah Cannon Research Institute
RECRUITINGNashville, Tennessee, 37203, United States
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Sarah Cannon Research Institute
RECRUITINGDallas, Texas, 75230, United States
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Stanford Cancer Institute
RECRUITINGPalo Alto, California, 94304, United States
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Temple University Health System
RECRUITINGPhiladelphia, Pennsylvania, 19111, United States
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Thomas Jefferson University
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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UCLA Santa Monica Medical Center
RECRUITINGSanta Monica, California, 90404, United States
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University Of California, Irvine
RECRUITINGOrange, California, 92868, United States
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
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University of California, San Diego
RECRUITINGLa Jolla, California, 92093, United States
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University of Colorado Cancer Center
RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Southern California
RECRUITINGLos Angeles, California, 90033, United States
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University of Texas
RECRUITINGHouston, Texas, 77030, United States
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University of Texas Health Science Center
RECRUITINGSan Antonio, Texas, 78229, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Yale University School of Medicine
RECRUITINGNew Haven, Connecticut, 06511, United States
Conditions
Explore the condition pages connected to this study.