New hope for japanese AML patients: experimental drug ziftomenib enters trial

NCT ID NCT07623616

Recruiting now Disease control Sponsor: Kyowa Kirin Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests an experimental drug called ziftomenib in 6 Japanese adults with a specific type of acute myeloid leukemia (AML) that has returned or not responded to treatment. The drug is taken as a pill once daily. The goal is to see if it can help control the disease and how safe it is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ziftomenib
What this could lead to: If successful, this could point toward a new treatment option for Japanese patients with a specific type of AML that has come back or not responded to other therapies.
What could go wrong: This is a very small, early-phase study with only 6 participants, so results may not apply broadly. The drug may not work or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia acute myeloid leukemia with mutated NPM1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA (AML)

Contacts and locations

Locations

Chiba Aoba Municipal Hospital
RECRUITING

Chiba, Japan
Dokkyo Medical University Hospital
RECRUITING

Tochigi, Japan
Gifu Municipal Hospital
RECRUITING

Gifu, Japan
Hyogo Medical University Hospital
NOT_YET_RECRUITING

Hyōgo, Japan
Imamura General Hospital
RECRUITING

Kagoshima, Japan
Jichi Medical University Hospital
RECRUITING

Tochigi, Japan
Jichi Medical University Saitama Medical Center
NOT_YET_RECRUITING

Saitama, Japan
Kanagawa Cancer Center
RECRUITING

Kanagawa, Japan
Kansai Medical University Hospital
RECRUITING

Osaka, Japan
Keio University Hospital
NOT_YET_RECRUITING

Tokyo, Japan
Kurashiki Central Hospital
RECRUITING

Okayama, Japan
Kyoto University Hospital
NOT_YET_RECRUITING

Kyoto, Japan
Matsumoto National Hospital
RECRUITING

Nagano, Japan
Mito Medical Center
RECRUITING

Ibaraki, Japan
Nagasaki University Hospital
RECRUITING

Nagasaki, Japan
Nippon Medical School Hospital
NOT_YET_RECRUITING

Tokyo, Japan
Okayama University Hospital
RECRUITING

Okayama, Japan
Osaka Metropolitan University Hospital
RECRUITING

Osaka, Japan
Tohoku University Hospital
RECRUITING

Miyagi, Japan
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
RECRUITING

Tokyo, Japan

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