New hope for kids with stubborn leukemia: targeted drug combo enters first human tests
NCT ID NCT06376162
First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 28 times
Summary
This early-phase trial tests a new drug called ziftomenib, which targets a specific genetic change in leukemia cells, combined with standard chemotherapy (FLA). It enrolls up to 20 children and young adults (ages 0–21) whose leukemia has come back or not responded to treatment. The main goal is to find the safest dose and understand how the drug works in the body, not yet to prove it cures the disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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CHU de Nantes - Hôpital Femme-Enfant-Adolescent
RECRUITINGNantes, Loire-Atlantique, 44093, France
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CHU de Reims - Hôpital Robert Debré
RECRUITINGParis, Île-de-France Region, 75019, France
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Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 30329, United States
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229-3026, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Fondazione IRCCS San Gerardo dei Tintori (Ospedale San Gerardo)
RECRUITINGMonza, 20900, Italy
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Hospital Infantil Universitario Niño Jesús
RECRUITINGMadrid, 28009, Spain
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Hospital Universitari Vall d'Hebrón
RECRUITINGBarcelona, 08035, Spain
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Memorial Sloan Kettering Cancer Center - New York
RECRUITINGNew York, New York, 10065, United States
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Ospedale Pediatrico Bambino Gesù
RECRUITINGRoma, Rome, 00165, Italy
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Prinses Maxima Centrum Kinderoncologie
RECRUITINGUtrecht, 3584 CS, Netherlands
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Sankt Anna-Kinderspital
RECRUITINGVienna, State of Vienna, 1090, Austria
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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SickKids - The Hospital for Sick Children
RECRUITINGToronto, Ontario, M5G 1X8, Canada
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St. Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105-3678, United States
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
Conditions
Explore the condition pages connected to this study.