New targeted drug trial offers hope for Tough-to-Treat ROS1 cancers

NCT ID NCT05118789

Recruiting now Disease control Sponsor: Nuvalent Inc. Source: ClinicalTrials.gov ↗

Summary

This clinical trial is testing an experimental drug called zidesamtinib for people with advanced cancers that have a specific genetic change called ROS1. The study aims to find the safest and most effective dose, and then see how well the drug shrinks tumors in patients with ROS1-positive lung cancer and other solid tumors. It's for adults (and teens in one group) whose cancer has progressed despite previous treatments.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atrium Health Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States

Contact
CHU de Nantes
RECRUITING

Nantes, 44000, France

Contact
Centre Legon Berard
RECRUITING

Lyon, 69008, France

Contact
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia

Contact
Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom

Contact
Chung Shan Medical University Hospital
RECRUITING

Taichung, 40201, Taiwan

Contact
Claudius Regaud Institute
RECRUITING

Toulouse, 31300, France

Contact
Cologne University Hospital
RECRUITING

Cologne, Germany

Contact
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada

Contact
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States

Contact
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy

Contact
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States

Contact
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States

Contact
Gregorio Marañón Hospital
RECRUITING

Madrid, 28007, Spain

Contact
Henry Ford Cancer Institute
RECRUITING

Detroit, Michigan, 48202, United States

Contact
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain

Contact
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain

Contact
IRCCS Istituto Tumori Giovanni Paolo II
RECRUITING

Bari, 70124, Italy

Contact
Institute Gustave Roussy
RECRUITING

Villejuif, 94805, France

Contact
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy

Contact
Istituto Nazionale Tumori Regina Elena
RECRUITING

Rome, 00128, Italy

Contact
Istituto Oncologico Veneto
RECRUITING

Padua, 35128, Italy

Contact
Kanagawa Cancer Center
RECRUITING

Kanagawa, 241-8515, Japan

Contact
Kindai University Hospital
RECRUITING

Osaka, 577-8502, Japan

Contact
MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Mass General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

Contact
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

Contact
NEXT Oncology - Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States

Contact
NYU Langone Health
RECRUITING

New York, New York, 10016, United States

Contact
National Cancer Center
RECRUITING

Gyeonggi-do, 10408, South Korea

Contact
National Cancer Center Hospital
RECRUITING

Tokyo, 104-0045, Japan

Contact
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore

Contact
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan

Contact
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan

Contact
National University Hospital Singapore
RECRUITING

Singapore, 119074, Singapore

Contact
Netherlands Cancer Institute
RECRUITING

Amsterdam, 1066, Netherlands

Contact
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States

Contact
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan

Contact
Ospedale Santa Maria delle Croci
RECRUITING

Ravenna, 48121, Italy

Contact
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia

Contact
Princess Margaret Cancer Research
RECRUITING

Toronto, Ontario, M5GG 1L7, Canada

Contact
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom

Contact
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea

Contact
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States

Contact
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea

Contact
Shizuoka Cancer Center
RECRUITING

Shizuoka, 411-8777, Japan

Contact
Stanford Medicine
RECRUITING

Palo Alto, California, 94305, United States

Contact
The Cancer Institute Hospital Of JFCR
RECRUITING

Tokyo, 135-8550, Japan

Contact
UC Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States

Contact
UCI Medical Center
RECRUITING

Orange, California, 92868, United States

Contact
UOMI Cancer Center - Clinica Tres Torres
RECRUITING

Barcelona, 08017, Spain

Contact
University Hospital Leuven
RECRUITING

Leuven, 3000, Belgium

Contact
University Hospital of A Coruña
RECRUITING

A Coruña, 15006, Spain

Contact
University Medical Centre Groningen
RECRUITING

Groningen, Netherlands

Contact
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States

Contact
University of Colorado Cancer Center
RECRUITING

Denver, Colorado, 80045, United States

Contact
University of Miami
RECRUITING

Coral Gables, Florida, 33146, United States

Contact
University of Washington / Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States

Contact
Università Politecnica Marche
RECRUITING

Ancona, 60121, Italy

Contact
Vall d'Hebron University Hospital
RECRUITING

Barcelona, 08035, Spain

Contact
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641-8510, Japan

Contact
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact
Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea

Contact

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED SOLID TUMOR METASTATIC SOLID TUMOR