New hope for hard-to-treat colorectal cancer? early trial combines three drugs
NCT ID NCT06102902
First seen Oct 31, 2025 · Last updated May 23, 2026 · Updated 29 times
Summary
This early-phase study tests whether adding a new drug (ZEN003694) to two approved cancer drugs (cetuximab and encorafenib) is safe and effective for people with a specific type of advanced colorectal cancer (BRAF V600E) that has stopped responding to standard treatments. About 30 adults will take part to find the best dose and check for side effects. The goal is to see if this triple combination can better control tumor growth.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, 92612, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Kansas Clinical Research Center
Fairway, Kansas, 66205, United States
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University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, 66211, United States
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University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
Conditions
Explore the condition pages connected to this study.