New hope for Hard-to-Treat leukemia? early trial launches
NCT ID NCT06366789
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a new oral drug, ZE46-0134, in 150 adults whose acute myeloid leukemia (AML) has come back or not responded to standard treatment. The study focuses on people with specific gene changes (FLT3 or spliceosome mutations). The main goals are to check safety, find the right dose, and get a first look at whether the drug can help control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ZE46-0134 (oral capsules)
What this could lead to
If it works, this could point toward a new treatment option for people with hard-to-treat AML who have specific gene mutations.
What could go wrong
This is a very early Phase 1 trial with only 150 participants, so it may not show clear benefit or could have unexpected side effects. Many early-stage drugs do not advance.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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China Medical University Hospital
NOT_YET_RECRUITINGTaichung, 404327, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Eastern Health - Box Hill Hospital
RECRUITINGMelbourne, Victoria, 3128, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact
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Gachon University Gil Medical Center
NOT_YET_RECRUITINGIncheon, Gyeonggi-do, 21565, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Korea University Anam Hospital
NOT_YET_RECRUITINGSeoul, 02841, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Linear Clinical Research Ltd
RECRUITINGPerth, Western Australia, 6009, Australia
Contact
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
Contact
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National Cheng Kung University Hospital
NOT_YET_RECRUITINGTainan, 704302, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact
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Seoul National University Hospital
NOT_YET_RECRUITINGSeoul, 03080, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taichung Veterans General Hospital
NOT_YET_RECRUITINGXitun, 407219, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare
NOT_YET_RECRUITINGNew Taipei City, 235041, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Alfred Hospital
RECRUITINGMelbourne, Victoria, 3004, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Catholic University of Korea Seoul St. Mary's Hospital
NOT_YET_RECRUITINGSeoul, 06591, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Ohio State University
RECRUITINGColumbus, Ohio, 43210, United States
Contact
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The University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact
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The University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
Contact
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
Contact
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45219, United States
Contact
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University of Kansas
RECRUITINGLawrence, Kansas, 66160, United States
Contact
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University of Maryland
RECRUITINGCollege Park, Maryland, 20742, United States
Contact
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University of North Carolina
RECRUITINGChapel Hill, North Carolina, 27514, United States
Contact