New drug trial aims to tame rogue immune attack on kidneys

NCT ID NCT05707377

Ongoing Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

Summary

This study is testing if the drug zanubrutinib can help control primary membranous nephropathy, a kidney disease where the immune system attacks the kidneys. It will compare zanubrutinib against an existing drug, tacrolimus, in about 178 adults who are already on standard care. The main goals are to see if it reduces protein in the urine and helps more people achieve remission.

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Contacts and locations

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Locations

Aberdeen Royal Infirmary

Aberdeen, AB25 2ZN, United Kingdom
Amicis Research Center

Northridge, California, 91324-3528, United States
Beijing An Zhen Hospital, Capital Medical University

Beijing, Beijing Municipality, 100029, China
Carolina Nephrology

Spartanburg, South Carolina, 29306-3927, United States
Erciyes University Medical Faculty

Erciyes, 38030, Turkey (Türkiye)
Fakultni Nemocnice Olomouc

Olomouc, 77900, Czechia
Fujian Medical University Union Hospital

Fuzhou, Fujian, 350001, China
General Hospital of Ningxia Medical University

Yinchuan, Ningxia, 750004, China
Guangdong Provincial Peoples Hospital

Guangzhou, Guangdong, 510080, China
Guizhou Provincial Peoples Hospital

Guiyang, Guizhou, 550002, China
Hcfmusp Hospital Das Clinicas Da Faculdade de Medicina Da Universidade de Sao Paulo

São Paulo, 05403-000, Brazil
Instituto Pro Renal Brasil

Curitiba, 80420-011, Brazil
Intermed Consultants

Minneapolis, Minnesota, 55435-2130, United States
Istscientifico Di Pavia, Fondazione Smaugeri, Irccs, Clinica Del Lavoro E Della Riabilitazione

Pavia, 27100, Italy
Jiangsu Province Hospital

Nanjing, Jiangsu, 210029, China
Kidney Specialist of Southern Nevada (Ksosn)

Las Vegas, Nevada, 89106-4852, United States
Kocaeli University Research and Application Hospital Department of Nephrology

Kocaeli, 41380, Turkey (Türkiye)
Medical Company Llc

Grozny, Chechenskaya Respublika, 364029, Russia
Nanyang Central Hospital

Nanyang, Henan, 473000, China
Ott Healthcare, Inc (Corporate Medical Centre)

Scarborough Village, Ontario, M1H 3G4, Canada
Peking University First Hospital

Beijing, Beijing Municipality, 100034, China
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518036, China
Renmin Hospital of Wuhan University

Wuhan, Hubei, 430060, China
Royal Derby Hospital

Derby, DE22 3NE, United Kingdom
Rui Jin Hospital Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200025, China
Shandong Provincial Hospital

Jinan, Shandong, 250021, China
Shanghai General Hospital

Shanghai, Shanghai Municipality, 200080, China
Shanxi Provincial Peoples Hospital

Taiyuan, Shanxi, 030012, China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

Chengdu, Sichuan, 610071, China
Stanford University

Palo Alto, California, 94304, United States
The Affiliated Hospital of Qingdao University Branch South

Qingdao, Shandong, 266000, China
The First Affiliated Hospital of Baotou Medical College

Baotou, Inner Mongolia, 14017, China
The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, 530021, China
The First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, 315010, China
The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361003, China
The First Affiliated Hospital of Xinjiang Medical University

Ürümqi, Xinjiang, 830054, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital, Sun Yat Sen University

Guangzhou, Guangdong, 510080, China
The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310003, China
The First Hospital of Hebei Medical University

Shijiazhuang, Hebei, 50000, China
The Second Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150001, China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China
University of Cincinnati College of Medicine

Cincinnati, Ohio, 45267-2827, United States
Vseobecna Fakultni Nemocnice V Praze

Prague, 10000, Czechia
Weifang Peoples Hospital

Weifang, Shandong, 261000, China
Wuxi Peoples Hospital

Wuxi, Jiangsu, 214023, China
Zhejiang Provincial Peoples Hospital

Hangzhou, Zhejiang, 310014, China

Conditions

Explore the condition pages connected to this study.

PRIMARY MEMBRANOUS NEPHROPATHY