Cancer drug could ease rare nerve disorder
NCT ID NCT07392229
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether zanubrutinib, a drug used for certain blood cancers, can improve nerve function in people with anti-MAG neuropathy—a rare condition causing numbness, weakness, and balance problems. About 50 adults in Italy will take the drug for 12 months. Researchers will check if symptoms get better using standard nerve tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Zanubrutinib (a targeted cancer drug that blocks a protein called BTK)
- What this could lead to
- If successful, this could offer a new treatment option for a rare nerve disease that currently has few effective therapies.
- What could go wrong
- This is an early-phase trial with only 50 participants and no placebo group, so results may not be definitive. The drug also carries risks like infection and bleeding.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CTU Ematologia, Grande Ospedale Metropolitano Niguarda
RECRUITINGMilan, Milan, 20162, Italy
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SC UCO Ematologia, Ospedale Maggiore di Trieste
RECRUITINGTrieste, Trieste, 34129, Italy
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UOC Ematologia, Azienda Ospedale Università Padova
RECRUITINGPadova, PD, 35128, Italy