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Xenon gas MRI could give doctors a 3D window into damaged lungs

NCT ID NCT07823010

Diagnosis Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers at Cincinnati Children's Hospital are refining a lung imaging method that uses inhaled xenon gas during an MRI scan. The study enrolls children and adults who are already scheduled for a xenon MRI, including people who have had stem cell or lung transplants. The goal is to test three ways of using xenon signals to measure airflow, air sac size, and blood flow in the lungs, so doctors can better assess lung health without invasive procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyperpolarized xenon-129 gas used as an inhaled MRI contrast agent
What this could lead to
If it works, doctors could get detailed 3D maps of lung airflow, air sac damage, and blood flow without surgery or radiation, helping them track lung problems earlier in transplant and stem cell patients.
What could go wrong
This is an early technical development study, not a treatment trial, so it may not produce a usable imaging protocol. The scans require specialized equipment and breath-holds that some sick patients cannot manage, and the results may not generalize beyond the specific machines and patient groups tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 550 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is having a clinically-ordered hyperpolarized Xe gas MRI scan Exclusion Criteria: * Pregnancy or positive pregnancy test * Standard MRI exclusions

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HSCT Lung transplant recipient

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

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