Experimental drug targets genetic cause of kidney damage

NCT ID NCT04340362

Completed Disease control Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

Summary

This study tested an experimental drug called VX-147 in adults with a specific genetic form of kidney disease called APOL1-mediated FSGS. The trial involved 16 participants with confirmed genetic markers and kidney biopsy diagnosis. Researchers measured how well the drug reduced protein in urine, monitored safety, and tracked how the body processes the medication.

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Contacts and locations

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Locations

Barts Health NHS Trust

London, United Kingdom
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Bichat Hospital

Paris, France
Boston Medical Center

Boston, Massachusetts, 02118, United States
California Institute of Renal Research

San Diego, California, 92123, United States
Central Georgia Kidney Specialists PC

Macon, Georgia, 31201, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30329, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Duke University School of Medicine - Duke Molecular Physiology Institute

Durham, North Carolina, 27710, United States
Durham Nephrology Associates, PA

Durham, North Carolina, 27704, United States
Florida Premier Research Institute

Winter Park, Florida, 32789, United States
GCM Medical Group, PSC

San Juan, 00917, Puerto Rico
Georgia Nehphrology

Lawrenceville, Georgia, 30046, United States
Hopital Henri Mondor

Créteil, France
Hopitaux Universitaires Est Parisien - Hopital Tenon

Paris, France
Howard University Hospital

Washington D.C., District of Columbia, 20060, United States
Hôpital Bicêtre AP-HP

Le Kremlin-Bicêtre, France
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Kidney and Hypertension Specialists of Miami

Miami, Florida, 33150, United States
King's College Hospital NHS Foundation Trust - Guthrie Clinic

Southwark, United Kingdom
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Morehouse School of Medicine, Grady Memorial Hospital

Atlanta, Georgia, 30310, United States
Nephrology and Hypertension Associates, LTD

Tupelo, Mississippi, 38801, United States
Nevada Kidney Disease and Hypertension Centers

Las Vegas, Nevada, 89106, United States
Ochsner Medical Center - New Orleans

New Orleans, Louisiana, 70121, United States
Paragon Health, PC d/b/a Nephrology Center, PC

Kalamazoo, Michigan, 49007, United States
Privia Medical Group

Houston, Texas, 77095, United States
Prolato Clinical Research Center

Houston, Texas, 77054, United States
Renal Associates of Baton Rouge

Baton Rouge, Louisiana, 70808, United States
Renal and Transplant Associates of New England, PC

Springfield, Massachusetts, 01107, United States
SUNY Downstate

Brooklyn, New York, 11203, United States
Service de Nephrologie - Hopital Universitaire Necker

Paris, France
South Carolina Nephrology and Hypertension Center, Inc.

Orangeburg, South Carolina, 29118, United States
St Louis Kidney Care

St Louis, Missouri, 63136, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The George Washington University Medical Faculty Associates - Kidney Disease & Hypertension

Washington D.C., District of Columbia, 20037, United States
The Medicines Evaluation Unit

Manchester, United Kingdom
Tryon Medical Partners

Charlotte, North Carolina, 28210, United States
UNC Kidney Center Division of Nephrology & Hypertension

Chapel Hill, North Carolina, 27599, United States
University Hospitals of Leicester NHS Trust - Leicester General Hospital

Leicester, United Kingdom
University of Alabama at Birmingham - The Kirklin Clinic

Birmingham, Alabama, 35294, United States
Université Paris-Descartes / Hôpital Européen Georges Pompidou

Paris, France
Urban Family Practice

Buffalo, New York, 14201, United States
Vanderbilt University VU

Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.

GLOMERULOSCLEROSIS, FOCAL SEGMENTAL