New pill targets Hard-to-Treat lung cancer mutations
NCT ID NCT07699328
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study tests an experimental oral drug called VRN110755 in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer). The drug is designed to block cancer growth by targeting the EGFR protein and certain resistance mutations, including C797S. The trial aims to find the safest dose and see if the drug can shrink tumors, especially in patients whose cancer has stopped responding to other EGFR-targeted therapies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- VRN110755 (an oral drug that targets specific EGFR mutations in lung cancer cells)
- What this could lead to
- If successful, VRN110755 could offer a new treatment option for people with EGFR-mutant lung cancer, especially those whose cancer has stopped responding to other targeted therapies.
- What could go wrong
- This is an early-phase trial (Phase 1/2) with a small number of participants, so the drug may not prove effective or may cause unexpected side effects. It is not yet known if it will work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AP-HM Hôpital Nord
RECRUITINGMarseille, Bouches-du-Rhône, 13915, France
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Centre Georges François Leclerc
RECRUITINGDijon, Côte-d'Or, 21079, France
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Chungbuk National University Hospital
RECRUITINGCheongju-si, North Chungcheong, 28644, South Korea
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Hospital Kuala Lumpur
RECRUITINGKuala Lumpur, 50586, Malaysia
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Hospital Regional Universitario de Málaga - Hospital Civil
RECRUITINGMálaga, 29011, Spain
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Hospital Umum Sarawak
RECRUITINGKuching, Sarawak, 93586, Malaysia
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
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ICO Badalona - Hospital Universitari Germans Trias i Pujol
RECRUITINGBadalona, Barcelona, 08916, Spain
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ICO l'Hospitalet - Hospital Duran i Reynals
RECRUITINGL'Hospitalet de Llobregat, Barcelona, 08908, Spain
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Institut Kanser Negara
RECRUITINGPutrajaya, 62250, Malaysia
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Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITINGKaohsiung City, 80756, Taiwan
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Monash Medical Centre Clayton
RECRUITINGClayton, Victoria, 3168, Australia
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National Cancer Centre Singapore
RECRUITINGSingapore, 168583, Singapore
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National Taiwan University Hospital
RECRUITINGTaipei, 10002, Taiwan
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Phramongkutklao Hospital
RECRUITINGThung Phaya Thai, Bangkok Metropolis, 10400, Thailand
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Prince of Wales Hospital
RECRUITINGHong Kong, 999077, Hong Kong
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Princess Margaret Cancer Centre
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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Queen Mary Hospital
RECRUITINGHong Kong, 999077, Hong Kong
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggi-do, 13620, South Korea
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Severance Hospital Yonsei University Health System
RECRUITINGSeoul, 03722, South Korea
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Songklanagarind Hospital Prince of Songkla University
RECRUITINGHat Yai, Changwat Songkhla, 90100, Thailand
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Southern Oncology Clinical Research Unit
RECRUITINGBedford Park, South Australia, 05042, Australia
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Taichung Veterans General Hospital
RECRUITINGTaichung, 407219, Taiwan
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Taipei Medical University Hospital
RECRUITINGTaipei, 11031, Taiwan
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Taipei Veterans General Hospital
RECRUITINGTaipei, 112201, Taiwan
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Tan Tock Seng Hospital
RECRUITINGSingapore, 308433, Singapore
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The Catholic University of Korea, St. Vincent's Hospital
RECRUITINGSuwon, Gyeonggi-do, 16247, South Korea
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University Malaya Medical Centre
RECRUITINGKuala Lumpur, 59100, Malaysia
Contact
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