Phage power: can viruses beat superbugs in the gut?
NCT ID NCT05715619
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests VRELysin, a mix of viruses that naturally attack VRE bacteria, in healthy adults and those carrying VRE in their gut. The goal is to see if it is safe and can reduce or eliminate VRE without antibiotics. Eighty participants will receive either the phage cocktail or a placebo, and researchers will monitor side effects and changes in VRE levels in stool.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
VRELysin (a cocktail of viruses that target and kill VRE bacteria)
What this could lead to
If it works, this could point toward a new way to clear VRE from the gut without antibiotics, reducing infection risk.
What could go wrong
This is a very early first-in-human trial with only 80 participants. The treatment may not reduce VRE levels or could cause side effects. The study is currently suspended.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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UPMC Presbyterian
Pittsburgh, Pennsylvania, 15213, United States