Drug trial aims to put the brakes on scarred lungs

NCT ID NCT05785624

Terminated Disease control Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether an investigational drug called vixarelimab could slow the decline in lung function for people with two types of progressive lung scarring diseases. About 286 adults with either idiopathic pulmonary fibrosis or lung disease related to systemic sclerosis (scleroderma) were randomly assigned to receive either vixarelimab or a placebo for one year, with an option for a second year of open-label treatment. The main goal was to see if the drug could better preserve breathing capacity, measured by a standard lung function test.

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Contacts and locations

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Locations

AZORG Campus Aalst-Moorselbaan

Aalst, 9300, Belgium
Arcispedale Santa Maria Nuova

Reggio Emilia, Emilia-Romagna, 42100, Italy
Asan Medical Center - PPDS

Seoul, 05505, South Korea
Azienda Ospedaliera Città della Salute e della Scienza di Torino

Turin, Piedmont, 10126, Italy
Azienda Ospedaliera Universitaria "Policlinico - Vittorio Emanuele" (Presidio Gaspare Rodolico)

Catania, Sicily, 95123, Italy
Azienda Ospedaliera Universitaria Careggi

Florence, Tuscany, 50134, Italy
Azienda Ospedaliera Universitaria Senese

Siena, Abruzzo, 53100, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona-Umberto I G.M. Lancisi G. Salesi

Ancona, The Marches, 60020, Italy
Banner University Medicine Lung Institute

Phoenix, Arizona, 85006-2506, United States
Barzilai Medical Center

Ashkelon, 7830604, Israel
Baylor College of Medicine

Houston, Texas, 77030, United States
Baylor Scott and White Health - Advanced Lung Disease Specialists - Dallas

Dallas, Texas, 75246-2073, United States
Bioclinica - Centro Integral En Reumatologia Sociedad Anónima de Capital Variable - PPDS

Guadalajara, Jalisco, CP 44160, Mexico
CEC SpA

Ñuñoa, 7750495, Chile
CHU de Liège

Liège, 4000, Belgium
CHU de Reims

Reims, 51100, France
CHUS H Clinico U de Santiago

Santiago de Compostela, LA Coruna, 15706, Spain
CICUM San Miguel

Americana, Jalisco, 44160, Mexico
Centro Médico Dra de Salvo

Buenos Aires, C1426ABP, Argentina
Centro de Investigacion del Maule

Talca, 3481349, Chile
Centro de Investigaciones Medicas Tucuman

San Miguel de Tucumán, T4000AXL, Argentina
Centro de Investigaciones Reumatologicas

San Miguel de Tucumán, T4000AXL, Argentina
Christchurch Hospital

Christchurch, 8011, New Zealand
Coastal Pulmonary and Critical Care PLC

St. Petersburg, Florida, 33704-2733, United States
Consultorios Médicos Dr. Doreski

Ciudad Autonoma Buenos Aires, C1426ABP, Argentina
Dr Anil Dhar Professional Medicine Corporation

Windsor, Ontario, N8X 5A6, Canada
Dr JM Engelbrecht Trial site

Cape Town, 7130, South Africa
Dunedin Hospital

Dunedin, New Zealand
Dynamic Drug Advancement Ltd.

Ajax, Ontario, L1S 2J5, Canada
EMED Centrum Uslug Medycznych Ewa Smialek

Rzeszów, 35-205, Poland
El Paso Pulmonary Association Elligo PPDS

El Paso, Texas, 79902-1124, United States
Emory Clinic

Atlanta, Georgia, 30322, United States
Enroll SpA - PPDS

Providencia, 7500587, Chile
Evangelische Lungenklinik Berlin

Berlin, 13125, Germany
Far East Memorial Hospital

New Taipei City, 220, Taiwan
Fondazione Policlinico Universitario A Gemelli

Rome, Lazio, 00168, Italy
Fundacion Scherbovsky

Mendoza, 5500, Argentina
Gachon University Gil Medical Center

Incheon, 21565, South Korea
GenHarp Clinical Solutions

Evergreen Park, Illinois, 60805-2758, United States
Groupe Hospitalier Bichat Claude Bernard

Paris, 75018, France
Hadassah Medical Center

Jerusalem, 9112001, Israel
Hannibal Regional Healthcare System HRMG Hannibal

Hannibal, Missouri, 63401-6890, United States
Hanyang University Medical Center

Seoul, 04763, South Korea
Hopital Avicenne

Bobigny, 93000, France
Hopital Louis Pradel

Bron, 69677, France
Hopital Nord AP-HM

Marseille, 13015, France
Hopital Pasteur 2

Nice, 06001, France
Hospital Brasilia

Brasília, Federal District, 71635580, Brazil
Hospital Clinic de Barcelona

Barcelona, 8036, Spain
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Dia do Pulmao

Blumenau, Santa Catarina, 89030-101, Brazil
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Dr. Jose Eleuterio Gonzalez

Monterrey, Nuevo León, Mexico
Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain
Hospital Universitario Son Espases

Palma de Mallorca, 07120, Spain
Hospital Universitario Virgen de la Victoria

Málaga, 29010, Spain
Hospital Universitario de Bellvitge

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital de Clinicas de Porto Alegre HCPA PPDS

Pôrto Alegre, Pará, 90035-903, Brazil
Hôpital Arnaud de Villeneuve

Montpellier, 34295, France
INSARES

Mendoza, Mendoza City, M5500CCG, Argentina
IU Health Ball Memorial Physicians Pulmonary and Critical Care Medicine

Muncie, Indiana, 47303-3432, United States
Instituto Ave Pulmo

Mar del Plata, B7602DCK, Argentina
Instituto De Patologias Respiratorias

San Miguel de Tucumán, 4000, Argentina
Instituto Del Buen Aire

Santa Fe, 3000, Argentina
Instituto Medico Rio Cuarto

Río Cuarto, 5800, Argentina
Instituto Medico de la Fundacion Estudios Clinicos

Rosario, S2013DTC, Argentina
IntraCare Health Center ? Prestige

Dallas, Texas, 75254, United States
Kaplan Medical Center

Rehovot, 7610001, Israel
Kelowna Allergy and Respiratory Health Clinic

Kelowna, British Columbia, V1W 1V3, Canada
L2 Ip - Instituto de Pesquisas Clinicas Ltda - ME

Brasília, Federal District, 70200-730, Brazil
Lady Davis Carmel Medical Center

Haifa, 34362, Israel
McGovern Medical School

Houston, Texas, 77030-1501, United States
Monash Health Monash Medical Centre

Clayton, Victoria, 3168, Australia
Northwestern Medicine - Northwestern Medicine Glen

Glenview, Illinois, 60026-8039, United States
Ospedale S. Giuseppe Multimedica

Milan, Lombardy, 20123, Italy
PULMAG Grzegorz Gasior Marzena Kociolek Spolka Cywilna

Sosnowiec, 41-208, Poland
Piedmont Pulmonary and Sleep Medicine Buckhead

Atlanta, Georgia, 30309-1740, United States
Presidio Ospedaliero GB Morgagni L Pierantoni

Forlì, Emilia-Romagna, 47121, Italy
Pulmonix LLC

Greensboro, North Carolina, 27403-4443, United States
Rabin Medical Center

Petah Tikva, 52621, Israel
Rambam Medical Center

Haifa, 3109601, Israel
Renstar Medical Research

Ocala, Florida, 34470, United States
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia
Ruhrlandklinik

Essen, 45239, Germany
SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi

Lodz, 90-153, Poland
Samsung Medical Center - PPDS

Seoul, 06351, South Korea
Shamir Medical Center Assaf Harofeh

Beer Jacob, 0073100, Israel
Southeastern Research Center

Winston-Salem, North Carolina, 27103-4029, United States
Southern Arizona VA Health Care System NAVREF PPDS

Tucson, Arizona, 85723-0001, United States
St Augustines Hospital

Durban, 4001, South Africa
St Vincent's Hospital Sydney

Darlinghurst, New South Wales, 2010, Australia
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Tel Aviv Sourasky Medical Center PPDS

Tel Aviv, 6423906, Israel
The Catholic University of Korea Eunpyeong St. Mary's Hospital

Seoul, 03312, South Korea
The Chaim Sheba Medical Center

Ramat Gan, 5262100, Israel
The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente

Torrance, California, 90502, United States
The University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104-5417, United States
UCLA Rheumatology

Los Angeles, California, 90095-8344, United States
Universitaetsklinikum Duesseldorf

Düsseldorf, 40225, Germany
University General Hospital of Heraklion

Heraklion, 711 10, Greece
University General Hospital of Larissa

Larissa, 412 21, Greece
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of California, San Francisco Medical Center

San Francisco, California, 94143-2204, United States
University of California, San Francisco-Fresno

Fresno, California, 93701-2302, United States
University of Cape Town Lung Institute UCTLI

Cape Town, 7700, South Africa
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Michigan Hospital

Ann Arbor, Michigan, 48109, United States
University of Southern California Keck School of Medicine

Los Angeles, California, 90033-1036, United States
University of Utah - PPDS

Salt Lake City, Utah, 84108-1287, United States
Waikato Hospital

Hamilton, 3248, New Zealand
Weston Hospital

Weston, Florida, 33331-3609, United States
Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy

Warsaw, 04-141, Poland

Conditions

Explore the condition pages connected to this study.

IDIOPATHIC PULMONARY FIBROSIS SYSTEMIC SCLEROSIS WITH LUNG INVOLVEMENT