Vitamin K2 cream shows promise for youthful skin in small trial
NCT ID NCT07403942
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a face-and-neck cream containing Vitamin K2 to see if it improves skin hydration, elasticity, and wrinkles. Thirty-six women aged 35 to 60 applied the cream to one side of their face and a placebo to the other side twice daily for 8 weeks. Researchers measured skin changes using special devices and imaging to compare the two sides.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin K2 (BioYoung™ MK-7) in a topical cream
- What this could lead to
- If it works, this could point toward a simple cosmetic cream that improves skin firmness and reduces wrinkles without invasive procedures.
- What could go wrong
- This is a small, early-stage cosmetic trial with only 36 participants, so results may not apply to everyone. The improvements are likely modest and temporary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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36 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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May 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Is a Chinese female aged between 35 and 60 years (inclusive). * Presents with facial skin concerns including dryness, dullness, and laxity. * Has crow's feet (outer canthus wrinkles) with a visual assessment grade of 2 to 4 (on a 0-6 scale). * Self-reports concerns about neck wrinkles. * Is in good general health at the time of screening. * Is willing and able to provide written informed consent. * Is willing and able to comply with all study procedures and product usage requirements for the duration of the study. Exclusion Criteria: * Is planning pregnancy, is pregnant, lactating, or within 6 months postpartum. * Has a history of severe systemic diseases, immunodeficiency, or autoimmune diseases. * Has a history of allergic diseases or has experienced cosmetic allergies within the past 1-2 years. * Has had dermatological diseases on the test areas (face and neck) or is undergoing related medical treatment within the past 3 months. * Has an active cold, influenza, or other acute illness at the study start that may affect participation. * Is currently participating, or has participated within the past month, in another clinical study involving the test areas. * Is deemed unsuitable for participation by a dermatologist's assessment.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beijing Sino-German Union Cosmetic Institute Co., Ltd.
Beijing, 100123, China