New drug trial offers hope for inoperable joint tumors
NCT ID NCT05059262
Summary
This study is testing whether an experimental drug called vimseltinib can shrink tumors in people with tenosynovial giant cell tumor (TGCT) when surgical removal isn't an option. About 123 adults with symptomatic TGCT will receive either vimseltinib or a placebo for 24 weeks, with MRI scans used to measure tumor response. After the initial period, all participants can receive the active drug in a long-term treatment phase.
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Contacts and locations
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Locations
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Cancer & Haematology Centre, The Churchill Hospital - Oxford University Hospitals NHS Foundation Trust
London, United Kingdom
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Centre Léon Bérard
Lyon, France
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Chris O'Brien Lifehouse
Camperdown, Australia
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City of Hope
Duarte, California, 91010, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke Sarcoma Research
Durham, North Carolina, 27710, United States
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
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Fundacion Jimenez Diaz
Madrid, Spain
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Helios Klinikum Berlin-Buch
Berlin, Germany
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Hospital Clinico San Carlos
Madrid, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
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Institut Bergonié
Bordeaux, France
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Institut Gustave Roussy
Villejuif, France
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Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Naples, Italy
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Istituto Nazionale Tumori Regina Elena
Rome, Italy
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Istituto Oncologico Veneto
Padua, Italy
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Istituto Ortopedico Rizzoli
Bologna, Italy
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Klinika Nowotworów Tkanek Miękkich, Kości i Czerniaków Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
Warsaw, Poland
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Leiden University Medical Center
Leiden, Netherlands
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Mayo Clinic Rochester
Rochester, Minnesota, 55902, United States
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McGill University
Montreal, Canada
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Memorial Sloan-Kettering Cancer Center
New York, New York, 10016, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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Oslo University Hospital
Oslo, Norway
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Prince of Wales Hospital
Hong Kong, Hong Kong
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Princess Margaret Hospital
Toronto, Canada
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Seattle Cancer Care Alliance
Seattle, Washington, 98109, United States
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UC Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University College London Hospitals
London, United Kingdom
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University Hospital Essen (Universitätsklinikum Essen)
Essen, Germany
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Kansas
Kansas City, Kansas, 66160, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Universitäts-Kinderspital beider Basel (UKBB)
Basel, Switzerland
Conditions
Explore the condition pages connected to this study.