New cocktail aims to tame dangerous leukemia in High-Risk patients
NCT ID NCT07187505
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests whether adding venetoclax to the standard two-drug regimen (ATRA and arsenic trioxide) can help patients with a rare blood cancer called acute promyelocytic leukemia (APL) who have very high white blood cell counts. These patients often face serious complications and higher early death rates. The trial will enroll 28 newly diagnosed adults and teens to see if the combination is safe and reduces early deaths.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Venetoclax (a drug that helps leukemia cells die), all-trans retinoic acid (ATRA), and arsenic trioxide (ATO)
What this could lead to
If successful, this combination could improve survival and reduce early complications for APL patients with very high white blood cell counts, a group that currently has poor outcomes.
What could go wrong
This is a small, early-phase study with only 28 participants and no control group, so results may not apply broadly. Adding venetoclax could also increase side effects like low blood counts or infections.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Hematology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road
Hefei, Anhui, 230022, China