New combo drug trial aims to control hard-to-treat prostate cancer
NCT ID NCT07244341
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether adding valemetostat to the standard drug darolutamide is safe and tolerable for men with metastatic castration-resistant prostate cancer (mCRPC), a type of prostate cancer that has spread and stopped responding to hormone therapy. About 60 adult men with this condition will receive the combination and be monitored for side effects and signs that the cancer is shrinking or slowing down. The goal is to find a safe dose and gather initial evidence of disease control.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Isreal Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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Cancer & Hematology Center
RECRUITINGGrand Rapids, Michigan, 49546-2302, United States
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Cancer Institute Hospital of JFCR
RECRUITINGKōtoku, 135-8550, Japan
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Carolina Urologic Research Center
RECRUITINGMyrtle Beach, South Carolina, 29572-4607, United States
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Dana Farber Cancer Institute
RECRUITINGNewton, Massachusetts, 02467, United States
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, 200032, China
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Fudan University Shanghai Cancer Center - Xuhui District
RECRUITINGShanghai, 200032, China
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Kobe City Med Cen Gen Hosp.
RECRUITINGKobe, 650-0047, Japan
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Mater Misericordiae University Hospital
RECRUITINGDublin, D07 R2WY, Ireland
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Medical College Of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226-3522, United States
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NEXT Oncology
RECRUITINGSan Antonio, Texas, 78229-6028, United States
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National Cancer Center Hospital East
RECRUITINGKashiwa-shi, 277-8577, Japan
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Northwell Health Cancer Institute (START NY)
RECRUITINGLake Success, New York, 11042-1118, United States
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Shanghai General Hospital
RECRUITINGShanghai, 200080, China
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Sun Yatsen University Cancer Center
RECRUITINGGuangzhou, 510060, China
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The First Affiliated Hospital of Wenzhou Medical University
RECRUITINGWenzhou, 325000, China
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Toho University Sakura Medical Center
RECRUITINGSakura-shi, 285-8741, Japan
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University of California San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92037-0698, United States
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Virginia Cancer Specialists (NEXT Virginia)
RECRUITINGFairfax, Virginia, 22031, United States