Ear zap may tame brain bleed inflammation

NCT ID NCT04557618

Recruiting now Disease control Sponsor: Anna Huguenard Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can reduce inflammation and improve recovery in people who have had a spontaneous brain bleed (subarachnoid hemorrhage). Fifty participants will receive either real or sham stimulation. Researchers will measure inflammatory markers in blood and spinal fluid, and check for complications like vasospasm or the need for a shunt.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Auricular vagus nerve stimulation device
What this could lead to: If it works, this could point toward a simple, drug-free way to reduce brain inflammation and prevent complications after a brain bleed.
What could go wrong: This is a small, early-phase study with only 50 participants. The device may not lower inflammation or improve outcomes, and some people may not tolerate the stimulation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

subarachnoid hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SUBARACHNOID HEMORRHAGE

Contacts and locations

Locations

Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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