New drug cocktail aims to shrink brain tumors in breast cancer patients
NCT ID NCT06764940
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether the combination of utidelone and capecitabine can shrink brain tumors in people with HER2-negative breast cancer that has spread to the brain. About 120 participants will receive either utidelone alone or with capecitabine. The main goal is to see how many patients have their brain tumors shrink significantly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Utidelone and capecitabine
- What this could lead to
- If successful, this combination could offer a new treatment option for breast cancer patients whose disease has spread to the brain, potentially shrinking tumors and extending life.
- What could go wrong
- This is a mid-stage trial with only 120 participants, so results may not apply to everyone. The drugs can cause side effects like nerve damage, hand-foot syndrome, and fatigue.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Augusta University
RECRUITINGAugusta, Georgia, 30912, United States
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Biosresearch Partner
RECRUITINGHialeah, Florida, 33013, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cancer & Blood Research Center, LLC
RECRUITINGLos Alamitos, California, 90720, United States
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City of Hope--Duarte
NOT_YET_RECRUITINGDuarte, California, 91010, United States
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Community Clinical Trials
RECRUITINGKingwood, Texas, 22751, United States
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Comprehensive Cancer Centers of Nevada
RECRUITINGLas Vegas, Nevada, 89169, United States
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D&H Cancer Research Center
RECRUITINGMargate, Florida, 33063, United States
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FOMAT Medical Research (Network)
RECRUITINGOxnard, California, 93030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Profound Research LLC
RECRUITINGFarmington Hills, Michigan, 48334, United States
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Robert H. Lurie Comprehensive Cancer Center Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Scripps Health
RECRUITINGSan Diego, California, 92121, United States
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Stony Brook Cancer Center
RECRUITINGStony Brook, New York, 11794-7263, United States
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The Johns Hopkins Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine
NOT_YET_RECRUITINGBaltimore, Maryland, 21287, United States
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Tranquil Clinical Research
RECRUITINGWebster, Texas, 77598, United States
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Univ. of California Los Angeles
NOT_YET_RECRUITINGLos Angeles, California, 90095, United States
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University Of Colorado Hospital - Anschutz Cancer Pavilion
RECRUITINGAurora, Colorado, 80045, United States
Contact Email: •••••@•••••
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