New gene therapy combo tackles aggressive lymphoma in early trial
NCT ID NCT06743503
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage study is testing a new gene therapy called UB-VV400, alone and with the drug rapamycin, in 70 adults with relapsed or refractory large B-cell lymphoma. The main goals are to find safe doses and check for side effects. Researchers will also look for signs that the treatment shrinks tumors. The trial includes people who have and have not had prior CAR T-cell therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- UB-VV400 (a gene therapy) and rapamycin (an immunosuppressant drug)
- What this could lead to
- If it works, this could offer a new treatment option for people with aggressive B-cell lymphoma that has not responded to other therapies, including prior CAR T-cell therapy.
- What could go wrong
- This is a very early (Phase 1) trial with only 70 participants, so it is primarily testing safety and dosing. It may not show strong anti-cancer effects, and side effects from the gene therapy or rapamycin are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences
NOT_YET_RECRUITINGTianjin, China
-
The First Affiliated Hospital of Nanjing Medical University
RECRUITINGNanjing, China
More trials for these conditions
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- New combo therapy aims to boost remission in Hard-to-Treat lymphoma