Typhoid vaccine study probes gut immunity secrets
NCT ID NCT03970304
First seen Jun 25, 2026 · Last updated Jun 25, 2026
Summary
This study looks at how the typhoid vaccine changes the immune system and bacteria in the gut. About 87 healthy adults getting a routine colonoscopy will either receive the vaccine before the procedure, after, or not at all. Researchers will analyze blood, tissue, and stool samples to understand the body's response.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Universtiy of Maryland, Baltimore, Center for Vaccine Development and Global Health
Baltimore, Maryland, 21201, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vivotif Typhoid Oral Vaccine (Ty21a)
What this could lead to
If successful, this could help design better typhoid vaccines and improve understanding of how vaccines interact with gut health.
What could go wrong
This is an early-stage observational study, not testing a new treatment. Results may not lead to direct health benefits or apply to broader populations.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.