Race to save insulin cells in new diabetes patients

NCT ID NCT04628481

Terminated Disease control Sponsor: Dompé Farmaceutici S.p.A Source: ClinicalTrials.gov ↗

Summary

This study tested whether an oral medication called ladarixin could help preserve the body's remaining insulin-producing cells in people recently diagnosed with type 1 diabetes. About 140 patients aged 14-45 took either ladarixin or a placebo for one year, with follow-up for another year. The main goal was to see if the treatment could slow the progression of diabetes by protecting these cells.

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Contacts and locations

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Locations

"Sapienza" Università di Roma- Azienda Ospedaliero Universitaria Policlinico Umberto I

Rome, 00161, Italy
"WakeMed Physician Practices - Pediatric Endocrinology - WakeMed Raleigh Medical Park Location"

Raleigh, North Carolina, 27610, United States
AdventHealth (Florida Hospital) - Diabetes Institute - Orlando

Orlando, Florida, 32804, United States
Aleksandre Aladashvili Clinic LLC

Tbilisi, 48102, Georgia
Atlanta Diabetes Associates (ADA)

Atlanta, Georgia, 30318, United States
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone"

Palermo, 90127, Italy
Azienda Ospedaliero-Universitaria Conzorziale Policlinico di Bari

Bari, 70124, Italy
Center of Excellence in Diabetes & Endocrinology (CEDE)

Sacramento, California, 95821-2123, United States
Centro regionale di Diabetologia Pediatrica "G. Stoppoloni", Azienda Ospedaliera Universitaria "Luigi Vanvitelli"

Naples, Italy
Christiana Care Endocrinology Specialists

Newark, Delaware, 19713, United States
Clinical Center Nis, Clinic for endocrinology

Niš, 18000, Serbia
Clinical Center Nis, Clinic for endocrinology

Niš, Serbia
Clinical Center of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases

Belgrade, 11000, Serbia
Clinical center Kragujevac, Clinic for internal diseases, Center for endocrinology, diabetes and metabolic diseases

Kragujevac, 34000, Serbia
Clinique du Sud Luxembourg - Vivialia-Arlon

Arlon, Belgium
Cook Children's Endocrinology and Diabetes Program

Fort Worth, Texas, 76104, United States
Diabestesinstitut Heidelberg

Heidelberg, Germany
Diabetes Care Center - Hudson

Hudson, Florida, 34667-7151, United States
Die Praxis am Ludwigsplatz

Ludwigshafen am Rhein, Germany
Eastern Virginia Medical School (EVMS) - Strelitz Diabetes Center

Norfolk, Virginia, 23510, United States
General Hospital AZ Nikolaas

Sint-Niklaas, Belgium
Global Life Research Network

Miami, Florida, 33155, United States
Indiana University - Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Institut fuer Diabetes forschung in Muenster (IDFM)

Münster, Germany
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Pediatrico Bambino Gesu

Roma, Italy
Joslin Diabetes Center, Harvard Medical School

Boston, Massachusetts, 02215, United States
Medical Center - University of Freiburg

Freiburg im Breisgau, Germany
National Center for Diabetes Research LTD

Tbilisi, 48159, Georgia
National Institute of Endocrinology LTD

Tbilisi, 48159, Georgia
Ospedale Pediatrico G. Salesi - Centro Regionale di Diabetologia Clinica Pediatrica

Ancona, 60123, Italy
Phoenician Centers for Research and Innovation

Phoenix, Arizona, 85021, United States
Prairie Education and Research Cooperative d/b/a Central Illinois Diabetes and Clinical

Springfield, Illinois, 62711, United States
Schneider Children's Medical Center, Petah Tikva

Petah Tikva, 4920235, Israel
Schwerpunktpraxis fuer Diabetes & Ernaehrungsmedizin

Münster, Germany
Soroka Medical Center

Beersheba, Israel
Tbilisi Heart and Vascular Clinic LTD

Tbilisi, 48159, Georgia
Tel Aviv Sourasky Medical Center

Tel Aviv, Israel
Texas Children's Hospital

Houston, Texas, 77030, United States
The Cotton-O'Neil Diabetes and Endocrinology Center

Topeka, Kansas, 66606-28, United States
The University of Chicago

Chicago, Illinois, 60637, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
UBMD Physicians Group - Pediatrics - Conventus

Buffalo, New York, 14203, United States
UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
Universita Cattolica del Sacro Cuore - Policlinico Universitario "Agostino Gemelli"

Roma, Italy
Universitaetsklinikum Gessen und Marburg GmbH - Medizinische Klinik und Poliklinik III

Glessen, 35392, Germany
Universitair Ziekenhuis Brussel (UZB)

Jette, Belgium
University Children's Hospital

Belgrade, Serbia
University Children's Hospital, University Medical Center Ljubljana

Ljubljana, Slovenia
University of Alabama at Birmingham (UAB) - The Kirklin Clinic (TKC) - Multidisciplinary Comprehensive Diabetes Clinic (MCDC)

Birmingham, Alabama, 35294, United States
University of California San Diego

La Jolla, California, 92093, United States
University of Colorado School of Medicine - Barbara Davis Center for Childhood Diabetes (BDC) - Specialty Clinic

Aurora, Colorado, 80045, United States
University of Louisville

Louisville, Kentucky, 40292, United States
University of Pennsylvania Perelman School of Medicine

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh - UPMC

Pittsburgh, Pennsylvania, 15261, United States
Università Campus Bio-Medico di Roma (UCBM) - Policlinico Universitario

Roma, 00128, Italy
Università degli Studi Magna Graecia di Catanzaro, Azienda Ospedaliero-Universitaria Mater Domini

Catanzaro, Italy
Universitá degli Studi di Milano - Ospedale Luigi Saco

Milan, 20157, Italy

Conditions

Explore the condition pages connected to this study.

RECENT ONSET TYPE1 DIABETES