Twice-a-Year shot could revolutionize HIV prevention

NCT ID NCT04925752

Ongoing Prevention Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 study is testing whether a new drug called lenacapavir, given as an injection just twice a year, can safely prevent HIV infection. It enrolled over 3,200 cisgender men, transgender women, transgender men, and nonbinary people aged 16+ who have condomless sex with male partners and are at risk for HIV. The main goal is to see if this long-acting option is more effective than a daily pill or no prevention method at stopping HIV transmission.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Ararat Research Center

San Juan, PR, 00717, Puerto Rico
Asociacion Civil Impacta Salud y Educacion - Sede Barranco

Barranco, 15063, Peru
Asociacion Civil Impacta Salud y Educacion - Sede San Miguel

Lima, 15088, Peru
Asociacion Civil Selva Amazonica

Iquitos, Peru
BIOS Clinical Research

Palm Springs, California, 92262, United States
Bamrasnaradura Infectious Disease Institute

Nonthaburi, 11000, Thailand
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Be Well Medical Center

Berkley, Michigan, 48072, United States
Bridge HIV at the San Francisco Department of Public Health

San Francisco, California, 94102, United States
CAN Community Health

Miami Gardens, Florida, 33055, United States
CAN Community Health

Sarasota, Florida, 34237, United States
CAN Community Health Clinic

Jacksonville, Florida, 32207, United States
Center for Management and Research. SPDM-Paulista Association for the Development of Medicine-Hospital São Paulo/Federal

São Paulo, 06519-332, Brazil
Central Texas Clinical Research

Austin, Texas, 78705, United States
Centro Ararat- San Juan

San Juan, PR, 00909, Puerto Rico
Centro San Vincente

El Paso, Texas, 79915, United States
Centro de Investigacion Farmaceutica Especializada de Occidente S.C.

Guadalajara C.P., 44160, Mexico
Centro de Referência e Treinamento DST/AIDS

São Paulo, 04121-000, Brazil
Charles R. Drew University of Medicine and Science (CDU) - Clinical Translational Research Center (CTRC)

Los Angeles, California, 90059, United States
Cone Health/Regional Center for Infectious Disease Research Center

Greensboro, North Carolina, 27401, United States
Desmond Tutu Health Foundation

Cape Town, 7925, South Africa
Emory University

Atlanta, Georgia, 30303, United States
Emory University Hospital Midtown Infectious Disease Clinic

Atlanta, Georgia, 30308, United States
FPD-DTHF Ndevana Commuity Research Site

Vincent, 5217, South Africa
Fundacion Huesped

Buenos Aires, 1202, Argentina
Fundação Bahiana de Infectologia

Canela-Salvador, 40110-060, Brazil
Fundação de Medicina Tropical Doutor Heitor Vieira Dourado / Fundação Medicina Tropical do Amazonas - FMT/IMT/AM

Manauas, 69040-000, Brazil
Gary Richmond, MD, PA

Fort Lauderdale, Florida, 33316, United States
Grupo Hospitalar Conceição/ Hospital Nossa Senhora da Conceição S.A.

Porto Alegre, RS 91350 200, Brazil
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hospital General de Agudos JM Ramos Mejia

Buenos Aires, 1072, Argentina
Hospital General de Nova Iguaçu - HGNI

Nova Iguaçu, 26030-380, Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo, 01246-903, Brazil
Howard Brown Health Center

Chicago, Illinois, 60613, United States
Icahn School of Medicine at Mount Sinai- Mount Sinai Downtown

New York, New York, 10029, United States
Indiana University Infectious Diseases Research

Indianapolis, Indiana, 46202, United States
Institute of HIV Research and Innovation

Bangkok, 10330, Thailand
Instituto Nacional de Infectologia Evandro Chagas / Fundação Oswaldo Cruz - INI FIOCRUZ

Rio de Janeiro, 21040-360, Brazil
Instituto de Investigaciones Clinicas Mar del Plata

Buenos Aires, B7600, Argentina
Instituto de Medicina Tropical "Daniel Alcides Carrion", Facultad de Medicina Humana, UNMSM

Callao, 7006, Peru
Johns Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States
KC CARE Health Center

Kansas City, Missouri, 64111, United States
King Chulalongkorn Memorial Hospital

Bangkok, 10330, Thailand
LSU-CrescentCare Sexual Health Center- New Orleans Community Health Center

New Orleans, Louisiana, 70119, United States
Loma Linda University Clinical Trial Center Clinic

Loma Linda, California, 92354, United States
Medical University of South Carolina, Infectious Disease Clinic

Charleston, South Carolina, 29425, United States
Meharry Medical College Clinical and Transitional Research Center

Nashville, Tennessee, 37208, United States
Methodist University Hospital/University of Tennessee Health Science Center, Clinical Research Center

Memphis, Tennessee, 38103, United States
Midway Immunology & Research Center, LLC

Ft. Pierce, Florida, 34982, United States
Mills Clinical Research

Los Angeles, California, 90069, United States
NC TraCS Institute - CTRC; University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27514, United States
Norton Infectious Disease Specialists

Louisville, Kentucky, 40241, United States
Ofiice of Dr. Peter Shalit, MD

Seattle, Washington, 98104, United States
Open Arms Healthcare Center

Jackson, Mississippi, 39202, United States
Optimus Medical Group

San Francisco, California, 94102, United States
Orlando Immunology Center

Orlando, Florida, 32803, United States
Penn Prevention Unit

Philadelphia, Pennsylvania, 19104, United States
Philadelphia FIGHT Community Health Centers, Jonathan Lax Treatment Center

Philadelphia, Pennsylvania, 19107, United States
Prisma Health Internal Medicine Clinic

Greenville, South Carolina, 29605, United States
Prisma Health-Midlands Clinical Research Unit

Columbia, South Carolina, 29203, United States
RMR Core Center

Chicago, Illinois, 60612, United States
Ramathibodi Hospital, Mahidol University

Bangkok, 10400, Thailand
Research Institute for Health Sciences, Chiang Mai University

Chiang Mai, 50200, Thailand
Ruane Clinical Research Group Inc.

Los Angeles, California, 90036, United States
Setshaba Research Centre

Soshanguvhe, 0152, South Africa
South Jersey Infectious Disease

Somers Point, New Jersey, 08244, United States
Srinagarind Hospital, Khon Kaen University

Khon Kaen, 40002, Thailand
St Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
St. Michael's Medical Center

Newark, New Jersey, 07102, United States
The Aurum Institute Tembisa CRC, Clinic 4

Tembisa, 1632, South Africa
The Aurum Institute: Pretoria Clinical Research Centre

Pretoria, 87, South Africa
The Crofoot Research Center, INC

Houston, Texas, 77098, United States
The Fenway Institute

Boston, Massachusetts, 02215, United States
The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS research Centre

Bangkok, 10330, Thailand
The Hope Clinic at Emory University

Atlanta, Georgia, 30030, United States
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Los Angeles, California, 90502, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
Therafirst Medical Center

Fort Lauderdale, Florida, 33308, United States
UAB Sexual Health Research Clinic

Birmingham, Alabama, 35233, United States
UCLA CBAM Vine Street Clinic

Los Angeles, California, 90038, United States
UCSD Anti Viral Research Center

San Diego, California, 92103, United States
UT Health Science Center at Houston

Houston, Texas, 77009, United States
Unidade de Pesquisa Clinica em Vacinas (UPqVac) da Faculdade de Medicina da Universidade

Belo Horizonte - MG, 30130-100, Brazil
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Colorado Clinical and Translational Research Centers (CTRC)

Aurora, Colorado, 80045, United States
University of Illinois at Chicago, Department of Medicine, Division of Infectious Diseases, Project WISH

Chicago, Illinois, 60612, United States
University of Miami Miller School of Medicine Division of Infectious Disease Research - Converge Miami

Miami, Florida, 33136, United States
Via Libre

Lima, 15001, Peru
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27103, United States
Washington Health Institute

Washington D.C., District of Columbia, 20017, United States
Whitman-Walker Institute Inc.

Washington D.C., District of Columbia, 20009, United States
Wits Reproductive Health and HIV Institute (Wits RHI)

Johannesburg, 2038, South Africa
Yale University, School of Medicine

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTION