New drug combo shows promise for Hard-to-Treat cancers
NCT ID NCT04170153
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new drug called tuvusertib, given alone or with another drug (niraparib), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and see early signs of tumor shrinkage. About 161 participants are enrolled across multiple sites.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Addenbrooke's Hospital - Dept of Oncology
Cambridge, United Kingdom
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Beijing Cancer Hospital
Beijing, China
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Centro Integral Oncologico Clara Campal - Unidad de Fase I-Oncologica
Madrid, Spain
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Hospital Clinic de Barcelona - Servicio de Oncologia
Barcelona, Spain
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Hospital Clinico Universitario de Valencia - Servicio de Hematologia y Oncologia Medica
Valencia, Spain
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Hospital Universitari Vall d'Hebron - Oncology Dept.
Barcelona, Spain
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Mary Crowley Cancer Research Centers
Dallas, Texas, 75230, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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NEXT Oncology
Austin, Texas, 78758, United States
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National Cancer Center Hospital - Dept of Experimental Therapeutics
Chūōku, Japan
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National Cancer Center Hospital East - Dept of Experimental Therapeutics
Kashiwa-shi, Japan
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Northern Centre for Cancer Care - Sir Bobby Robson Cancer Trials Research Centre
Newcastle upon Tyne, United Kingdom
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Royal Marsden Hospital - Dept of Oncology
Sutton, United Kingdom
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The Christie Hospital - Dept of Oncology
Manchester, United Kingdom
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The Methodist Hospital Research Institute
Houston, Texas, 77030, United States
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University of Texas M. D. Anderson Cancer Center - Investigational Cancer Therapeutics
Houston, Texas, 77030, United States
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