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Tretinoin cream tested for fragile skin in seniors

NCT ID NCT07084116

Symptom relief Sponsor: James Thomas Pathoulas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether applying tretinoin 0.1% cream nightly to the forearms can reduce skin tears and bruising in people aged 55 and older. Fifteen participants with a history of skin tears and bruising used the cream on one arm and a bland cream on the other for six months. The goal was to see if the treatment lowers tear frequency and improves skin thickness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tretinoin 0.1% cream
What this could lead to
If it works, this could offer a simple cream to reduce skin tears and bruising in older adults with fragile skin.
What could go wrong
This is a small, early-phase study with only 15 people. Results may not apply to everyone, and tretinoin can cause skin irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

15 people

The number who actually took part.

Started

Jul 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (55+) * History of skin tears, at least 2 in the past month * History of skin bruising (solar purpura) * Ambulatory * Able to apply topical medication to oneself Exclusion Criteria: * \<55 years old) * Pregnant or breastfeeding * History of allergy to tretinoin * History of atopic dermatitis, psoriasis, bullous skin disease, cutaneous lupus, or cutaneous T cell lymphoma. * Planned cutaneous surgery on either forearm in the next 6 months * Use of any topical medication on the forearms within past month * Current or anticipated phototherapy of the forearms in the next 6 months * Current or anticipated chemotherapy within the next 6 months * Use of oral steroids within past month * Current or prior isotretinoin therapy within past 6 months * AV fistula of the arm

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dermatoporosis Skin tear Solar purpura

Contacts and locations

Locations

  • Palo Alto VA Medical Center

    Palo Alto, California, 94304, United States