Can a Dual-Antibody combo hold ovarian cancer at bay longer?
NCT ID NCT07779538
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This trial is testing whether adding trastuzumab to the standard maintenance drug bevacizumab can delay cancer progression in people with advanced ovarian, fallopian tube, or primary peritoneal cancer. Participants who have completed initial chemotherapy plus bevacizumab without their disease getting worse will be randomly assigned to receive either the two-drug combination or bevacizumab alone as ongoing maintenance therapy. The study will compare how long the cancer stays under control and monitor safety and side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- trastuzumab combined with bevacizumab
- What this could lead to
- If successful, this combination could extend the time before ovarian cancer progresses after initial treatment, potentially improving long-term outcomes.
- What could go wrong
- This is an early-to-mid-stage trial, so the combination may not prove more effective than bevacizumab alone. Side effects from adding trastuzumab are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 420 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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May 2030
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Participants voluntarily join this trial and sign an informed consent form. 2. Newly diagnosed stage III or IV epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer, confirmed by histological or cytological pathology. 3. Prior to first-line platinum-based doublet chemotherapy combined with bevacizumab. 4. No disease progression as assessed by the investigator after completion of first-line platinum-based therapy and before randomization. 5. Participants' homologous recombination deficiency test results must meet the criteria. 6. Participants have not received any anti-tumor therapy from the last dose of first-line platinum-based therapy until randomization. 7. Able to provide sufficient fresh or archived tumor tissue specimens for testing at the sponsor-designated central laboratory. 8. ECOG PS score: 0-1. 9. Expected survival ≥ 12 weeks. 10. Laboratory tests within 7 days prior to randomization confirm that important organ function meets the requirements. 11. Female participants of childbearing potential must have a negative serum human chorionic gonadotropin (HCG) test within 7 days prior to randomization and must not be breastfeeding; female participants of childbearing potential must agree to adhere to contraception from the date of signing the informed consent form until 7 months after the last dose. Exclusion Criteria: 1. Participants with untreated or active central nervous system (CNS) metastases; a history of meningeal metastases or current meningeal metastases. 2. Participants with clinically symptomatic, poorly controlled, or moderate to severe pleural effusion, pericardial effusion, or ascites. 3. Participants with a history of or concurrent other malignancies, excluding cured basal cell carcinoma of the skin, cervical carcinoma in situ, ductal carcinoma in situ of the breast, papillary thyroid carcinoma, and other malignancies that have been adequately treated and cured for ≥5 years prior to randomization with evidence of no recurrence or metastasis. 4. Participants with a history of interstitial pneumonia/interstitial lung disease requiring steroid treatment, non-infectious pneumonia (such as radiation pneumonitis), current or suspected interstitial pneumonia/interstitial lung disease, non-infectious pneumonia, or other active pneumonia; or those with severe asthma, severe chronic obstructive pulmonary disease (COPD), restrictive lung disease, or other lung damage within 6 months prior to randomization. 5. 6\. Individuals with active pulmonary tuberculosis; those who have received adequate and regular treatment and have stopped anti-tuberculosis treatment for ≥3 months prior to randomization are eligible for enrollment. 7\. Individuals with poorly controlled or severe cardiovascular disease. 8. Individuals who have experienced arterial/venous thrombotic events within 6 months prior to randomization. 9\. Individuals who have experienced NCI-CTCAE v6.0 grade ≥2 bleeding events within 1 month prior to randomization. 10\. Individuals with known hereditary or acquired bleeding (e.g., coagulation disorders) or thrombotic tendency. 11\. Individuals who have experienced or are expected to experience gastrointestinal perforation or fistula, tracheal fistula, urethral fistula, or abdominal abscess in the near future. 12\. Individuals with gastrointestinal obstruction or symptoms and signs of gastrointestinal obstruction within 3 months prior to randomization; individuals who have previously undergone intestinal stent implantation and whose intestinal stent has not been removed by the screening period. 13\. Participants who have experienced severe infection within 1 month prior to randomization. 14\. Participants who have tested positive for human immunodeficiency virus (HIV); participants with known active hepatitis. 15\. Participants who have undergone major surgery within 4 weeks prior to randomization or whose surgical side effects have not recovered or stabilized prior to randomization. 16. Patients who may receive other systemic anti-tumor therapies during treatment or are scheduled for further debulking surgery. 17\. Patients whose toxicity from previous anti-tumor therapy has not recovered to grade ≤1 according to the NCI-CTCAE v6.0 classification. 18\. Patients with known hypersensitivity to any component of the SHR-A1811 product or other monoclonal antibody drugs. 19\. Patients who, in the investigator's judgment, have other factors that may affect the trial results or force the trial to be terminated midway, such as alcoholism, drug abuse, substance abuse, criminal detention, etc., as well as other serious illnesses (including mental illness) requiring concomitant treatment, serious abnormal laboratory test results, or any other circumstances that may increase the risk of participation in the trial, interfere with the trial results, or make them unsuitable for participation in the trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100020, China
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Yunnan Cancer Hospital
Yunnan, Kunming, 650118, China
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Zhejiang Cancer Hospital
Zhejiang, Hangzhou, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A multicenter, randomized, open-label phase III study of IBI354 versus Investigator's choice of chemotherapy in patients with platinum-resistant ovarian, primary peritoneal, or fallopian tube cancer
- Operationalising multifactorial ovarian cancer risk assessment using the CanRisk tool versus standard practices.
- Can a new drug shrink advanced solid tumors?
- Can ultrasound sharpen the surgical map for ovarian cancer near the liver?
- Blood vessel cells in a simple blood test may predict ovarian cancer therapy success
- Can a radioactive antibody light up hidden tumors on PET scans?