Can a common drug stop brain bleeds? major trial launches

NCT ID NCT05836831

Recruiting now Disease control Sponsor: Christian Medical College and Hospital, Ludhiana, India Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large, phase 4 trial tests whether tranexamic acid, a drug that helps blood clot, can improve outcomes for people with a bleeding stroke. About 3400 adults will receive either the drug or standard care within 4.5 hours of symptoms. The main goal is to see if it reduces deaths at 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tranexamic acid
What this could lead to: If it works, this could provide a simple, widely available treatment to reduce bleeding and improve survival after a hemorrhagic stroke.
What could go wrong: This is a large trial, but earlier studies on tranexamic acid for brain bleeds have shown mixed results. The drug may not meaningfully improve outcomes and could increase the risk of blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hemorrhagic Stroke intracerebral hemorrhage stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRACEREBRAL HEMORRHAGIC STROKE

Contacts and locations

Locations

ASTER MIMS Hospital
RECRUITING

Calicut, Kerala, 673016, India
All India Institute of Medical Sciences
RECRUITING

Bilāspur, Himachal Pradesh, 174001, India
All India Institute of Medical Sciences
RECRUITING

New Delhi, National Capital Territory of Delhi, 110029, India
All India Institute of Medical Sciences
RECRUITING

Bhubaneswar, Odisha, 751019, India
Amrita Institute for Medical Sciences and Research Center
RECRUITING

Kochi, Kerala, 682041, India
Apollo Excelcare Hospitals
RECRUITING

Guwahati, Assam, 781033, India
Artemis Hospital
RECRUITING

Gurgaon, Haryana, 122001, India
Assam Medical College
RECRUITING

Dibrugarh, Assam, 786001, India
Atal Institute of Medical Super Specilities, (AIMSS) Chamiana
RECRUITING

Shimla, Himachal Pradesh, 171001, India
Baby Memorial Hospital
RECRUITING

Calicut, Kerala, 673004, India
Bangur Institute of Neurosciences
RECRUITING

Kolkata, West Bengal, 700020, India
Baptist Christian Hospital
RECRUITING

Tezpur, Assam, 784001, India
Bharati Vidyapeeth DTU Medical College
RECRUITING

Pune, Maharashtra, 411043, India
CARE Hospitals
RECRUITING

Hyderabad, Telangana, Hyderabad, India
Christian Medical College Vellore
RECRUITING

Vellore, Tamil Nadu, 632517, India
Christian Medical College and Hospital, Ludhiana, Punjab
RECRUITING

Ludhiana, Punjab, 141008, India
Dr Ramesh Cardiac and Multispecialty Hospital
RECRUITING

Guntur, Andhra Pradesh, 522004, India
Dr. Kamakshi Memorial Hospital
RECRUITING

Chennai, Tamil Nadu, 600100, India
Fortis Escorts Hospital
RECRUITING

Jaipur, Rajasthan, 302017, India
Fortis Hospital Mulund
RECRUITING

Mumbai, Maharashtra, 400078, India
Government General Hospital
RECRUITING

Guntur, Andhra Pradesh, 522001, India
Government Medical College Trivandrum
RECRUITING

Thiruvananthapuram, Kerala, 695011, India
Guru Gobind Singh Medical College and Hospital
RECRUITING

Farīdkot, Punjab, 151203, India
Guwahati Neurological Research Center
RECRUITING

Guwahati, Assam, 781006, India
Holy Spirit Hospital
RECRUITING

Mumbai, Maharashtra, 400093, India
Institute of Human Behaviour and Allied Sciences
RECRUITING

New Delhi, National Capital Territory of Delhi, 110095, India
Institute of Medical Sciences of the Banaras Hindu University (BHU)
RECRUITING

Varanasi, Uttar Pradesh, 221005, India
Institute of Neurosciences
RECRUITING

Kolkata, West Bengal, 700017, India
Jawaharlal Institute of Postgraduate Medical Education and Research
RECRUITING

Puducherry, Tamil Nadu, 605006, India
KG Hospital and Post Graduate Medical Institute Coimbatore
RECRUITING

Coimbatore, Tamil Nadu, 641018, India
KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre
RECRUITING

Belagavi, Karnataka, 590010, India
Kasturba Medical College Manipal
RECRUITING

Manipal, Karnataka, 576104, India
King George's Medical University
RECRUITING

Lucknow, Uttar Pradesh, 226003, India
Lalitha Super Specialty Hospital
RECRUITING

Guntur, Andhra Pradesh, 522001, India
Manipal Hospital
NOT_YET_RECRUITING

Panjim, Goa, 403004, India
Manipal Hospital
NOT_YET_RECRUITING

Bangalore, Karnataka, 560017, India
National Institute of Mental Health and Neuro-Sciences
NOT_YET_RECRUITING

Bangalore, Karnataka, 560029, India
PBM Hospital
RECRUITING

Bikaner, Rajasthan, 334001, India
Postgraduate Institute for Medical Education and Research
RECRUITING

Chandigarh, 160012, India
Ruby Hall Clinic
RECRUITING

Pune, Maharashtra, 411001, India
Santokba Durlabhji Memorial Hospital
RECRUITING

Jaipur, Rajasthan, 302015, India
Shree Krishna Hospital Pramukhswami Medical College
RECRUITING

Anand, Gujarat, 388325, India
Sparsh Superspeciality Hospital
RECRUITING

Bangalore, Karnataka, 560022, India
Sree Chitra Tirunal Institute for Medical Sciences and Technology
RECRUITING

Thiruvananthapuram, Kerala, 695011, India
St Stephen's Hospital
RECRUITING

Delhi, 110054, India
Tezpur Medical College and Hospital
RECRUITING

Tezpur, Assam, 784153, India
The Calcutta Medical Research Center
RECRUITING

Kolkata, West Bengal, 700027, India
Tirunelveli Medical College
RECRUITING

Tirunelveli, Tamil Nadu, 627011, India