New antibody therapy aims to fight rare amyloidosis

NCT ID NCT07266116

Recruiting now Disease control Sponsor: Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a new drug called TQB2934 for people with systemic light chain amyloidosis, a rare disease where abnormal proteins damage organs. The drug is a bispecific antibody that helps the immune system target and destroy harmful cells. The trial will enroll 70 adults who have not responded to prior treatments, to see if the drug can improve blood response rates and is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TQB2934 (a bispecific antibody that helps immune cells target and kill harmful plasma cells)
What this could lead to: If it works, this could offer a new treatment option for people with light chain amyloidosis who have not responded to standard therapies.
What could go wrong: This is an early-phase trial with only 70 participants, so results may not apply to everyone. The drug could cause side effects like immune reactions or organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AL amyloidosis primary systemic amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LIGHT CHAIN AMYLOIDOSIS

Contacts and locations

Locations

Affiliated Hospital of Hebei University
NOT_YET_RECRUITING

Baoding, Hebei, 050031, China
Anyang People's Hospital
NOT_YET_RECRUITING

Anyang, Henan, 455000, China
China-Japan Union Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130033, China
China-Japan Union Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130033, China
Chinese Academy of Medical Sciences Hematology Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 301617, China
Fujian Medical University Union Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 362011, China
Guangzhou First Municipal People's Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510180, China
Hangzhou First People's Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310006, China
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 212028, China
Peking University First Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100034, China
Peking University People's Hospital
RECRUITING

Beijing, Beijing Municipality, 100044, China
Peking University ShenZhen Hospital
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518036, China
Qingdao municipal hosptial (group)
NOT_YET_RECRUITING

Qingdao, Shandong, 266001, China
Renji Hospital Shanghai Jiaotong University School Of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200001, China
Shengjing Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, 11004, China
Sichuan Provincial People's Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610000, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310018, China
Southwest Hospital, Third Military Medical University (Army Medical University)
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400038, China
The Affiliated Hospital of Guizhou Medical University
NOT_YET_RECRUITING

Guiyang, Guizhou, 550004, China
The First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150000, China
The First Affiliated Hospital of Xi'an Jiao Tong University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710000, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital, Sun Yat-sen University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510080, China
The First Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310018, China
The First Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310018, China
The first hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130031, China
The second Affiliated hospital of dalian medical university
NOT_YET_RECRUITING

Dalian, Liaoning, 116021, China

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