Could whole blood save more lives in trauma emergencies?

NCT ID NCT04684719

First seen Feb 16, 2026 · Last updated Apr 26, 2026 · Updated 5 times

Summary

This study tested whether giving whole blood to injured patients with severe bleeding before they reach the hospital can save more lives than standard care. Over 1,000 adults at risk of hemorrhagic shock were enrolled across 10 trauma centers. The goal was to see if whole blood reduces deaths within 30 days and to understand how the age of the blood affects its effectiveness.

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Contacts and locations

Locations

  • Metrohealth Systems

    Cleveland, Ohio, 44109, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Cincinatti

    Cincinnati, Ohio, 45267, United States

  • University of Louisville

    Louisville, Kentucky, 40292, United States

  • University of Mississippi Medical Center (UMMC)

    Jackson, Mississippi, 39216, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Tennessee Medical Center

    Knoxville, Tennessee, 37920, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

  • University of Washington

    Seattle, Washington, 98104, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.