New pill shows promise for Hard-to-Treat breast cancer in early trial
NCT ID NCT05683418
First seen May 14, 2026 · Last updated May 14, 2026
Summary
This study tests a new daily pill called TOS-358 in women with a specific type of advanced breast cancer (HR+ HER2-) that has a PIK3CA gene change. The main goals are to find the best dose and see if it is safe when taken alone or with standard treatments. About 241 adults will take part in this early-phase trial.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Email: •••••@•••••
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Clinica Universidad de Navarra
RECRUITINGPamplona, 31008, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Comprehensive Cancer Centers of Nevada
RECRUITINGLas Vegas, Nevada, 89169, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Email: •••••@•••••
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Hospital Clinico San Carlos
RECRUITINGMadrid, 28040, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clinico Universitario de Valencia
RECRUITINGValencia, 46010, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON
RECRUITINGBarcelona, 08035, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NEXT Oncology - Hospital Quironsalud Barcelona - PPDS
RECRUITINGBarcelona, 08023, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NEXT Oncology - Hospital Quironsalud Madrid - PPDS
RECRUITINGPozuelo de Alarcón, 28223, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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START Barcelona HM Nou Delfos
RECRUITINGBarcelona, 08023, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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START MADRID Hospital Universitario Fundacion Jimenez Diaz - EDOS
RECRUITINGMadrid, 28050, Spain
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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START MADRID Hospital Universitario HM Sanchinarro - CIOCC
RECRUITINGMadrid, 28050, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sarah Cannon Cancer Center
RECRUITINGNashville, Tennessee, 37203, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Oncology - Flower Mound
RECRUITINGFlower Mound, Texas, 75028, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact Email: •••••@•••••
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Vanderbilt-Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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