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Promising immunotherapy combo takes on advanced liver cancer

NCT ID NCT04523493

Ongoing Disease control Sponsor: Shanghai Junshi Bioscience Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether adding the immunotherapy drug toripalimab to the standard targeted therapy lenvatinib helps people with advanced liver cancer live longer. About 530 participants will receive either the combination or a placebo plus lenvatinib. The study is double-blind, meaning neither patients nor doctors know who gets the extra drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Toripalimab (an immunotherapy drug) combined with lenvatinib (a targeted therapy drug)
What this could lead to
If successful, this combination could become a new standard first-line treatment for advanced liver cancer, potentially extending survival.
What could go wrong
This is an early-stage Phase 3 trial; results may not confirm benefit. Immunotherapy can cause serious immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED HEPATOCELLULAR CARCINOMA (HCC)

Contacts and locations

Locations

  • A.O.U. Citta della Salute e della Scienza di Torino

    Tortona, Italy

  • AOUI Verona - Policlinico "G.B. Rossi" di Borgo Roma

    Verona, 37134, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126, Italy

  • Centrum Medyczne Pratia Poznań

    Skórzewo, 60-185, Poland

  • Communal Enterprise Volyn Regional Clinical Hospital of Volyn Regional Council

    Lutsk, 43018, Ukraine

  • Communal Non-Profit Institution of Kharkiv Regional Council Regional Clinical Specialized Dispensary of Radiation Protection of Population

    Kharkiv, 61166, Ukraine

  • Communal Non-commercial Enterprise City Clinical Hospital #4 of Dnipro City Council, Department of Chemotherapy

    Dnipro, 49102, Ukraine

  • Communal Non-commercial Enterprise Odesa Regional Clinical Hospital of Odesa Regional Council, Department of General Surgery

    Odesa, 65025, Ukraine

  • Communal Non-commercial Enterprise Zaporizhzhia Regional Antitumor Center of Zaporizhzhia Regional Council

    Zaporizhzhia, 69040, Ukraine

  • Communal Non-commercial Enterprise of Sumy Regional Council, Sumy Regional Clinical Oncological Dispensar

    Sumy, 40022, Ukraine

  • Communal Non-profit Enterprise "Regional Center of Oncology", Department of Abdominal Organs Oncosurgery

    Kharkiv, 61070, Ukraine

  • Copernicus Podmiot Leczniczy sp. z o.o., Wojewodzkie Centrum Onkologii, Oddzial Onkologii Klinicznej/Chemioterapii

    Gdansk, 80-219, Poland

  • Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico,Oncologia Medica

    Milan, 20122, Italy

  • ID Clinic

    Mysłowice, 41-400, Poland

  • IRCCS Fondazione Giovanni Pascale, Istituto Nazionale Dei Tumori

    Naples, 80131, Italy

  • Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Klinika Onkologii i Radioterapii

    Warsaw, 02-034, Poland

  • National Cancer Centre Singapore

    Singapore, 168583, Singapore

  • PRATIA MCM Kraków, ul. Pana Tadeusza 2,

    Krakow, 30-727, Poland

  • Qinhuai Medical Area, General Hospital of PLA Eastern Theater Command

    Nanjing, Jiangsu, 21000, China

  • State Inst. O.O.Shalimov Nat. scientific certer of Surgery and Transplantology of Nat. Academy of Med.Sciences of Ukraine, Dep.of Oncology

    Kyiv, 03126, Ukraine

  • Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie, Oddzial Dzienny Chemioterapii

    Koszalin, 75-581, Poland

  • Wielkopolskie Centrum Onkologii, Oddział Onkologii Klinicznej i Immunoonkologii z Pododdziałem Dziennym i Izbą Przyjęć

    Poznan, 61-866, Poland

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