Immunotherapy-Chemo cocktail shows promise for Tough-to-Treat throat cancer
NCT ID NCT06457503
First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 5 times
Summary
This study is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy (cisplatin and gemcitabine) can help people with recurrent or metastatic nasopharyngeal cancer that hasn't been treated before. About 100 participants will receive the combination intravenously every three weeks. The main goal is to see how many patients' tumors shrink or disappear, with secondary goals looking at how long that effect lasts and how long people live without their cancer getting worse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- toripalimab (an immunotherapy drug) combined with cisplatin and gemcitabine (chemotherapy drugs)
- What this could lead to
- If successful, this combination could offer a new first-line treatment option for people with recurrent metastatic nasopharyngeal cancer, potentially improving response rates and delaying disease progression.
- What could go wrong
- This is a single-arm, non-randomized study, so results may be less reliable than a randomized trial. Side effects from chemotherapy and immunotherapy can be significant, and the treatment may not work for all participants.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Boston Medical Center
RECRUITINGBoston, Massachusetts, 02118, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Emory Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Froedtert Hospital and the Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Henry Ford Cancer Center
RECRUITINGDetroit, Michigan, 48202, United States
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Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
WITHDRAWNNew York, New York, 10016, United States
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Penn State Milton S. Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
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Princess Margaret Cancer Centre
RECRUITINGToronto, Canada, MSG 1Z5, Canada
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University of Arkansas for Medical Sciences
RECRUITINGLittle Rock, Arkansas, 72205, United States
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University of California, Irvine
RECRUITINGIrvine, California, 92697, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94115, United States
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University of Cincinnati Medical Center
RECRUITINGCincinnati, Ohio, 45219, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Email: •••••@•••••
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