Major drug trial for Muscle-Weakening disease halted after just 6 patients
NCT ID NCT05132569
Summary
This study aimed to test whether an oral drug called tolebrutinib could help control symptoms and improve daily life for adults with moderate-to-severe generalized myasthenia gravis (gMG), a chronic autoimmune disease that causes muscle weakness. It was a large Phase 3 trial designed to compare the drug against a placebo over 26 weeks, followed by a longer-term extension. However, the trial was terminated very early, enrolling only 6 participants, so no conclusions about the drug's effectiveness for gMG could be drawn from this study.
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Contacts and locations
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Locations
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Georgetown University-Site Number:8400008
Washington D.C., District of Columbia, 20007, United States
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Harvard Medical School - Brigham and Women's Hospital-Site Number:8400004
Boston, Massachusetts, 02115, United States
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Investigational Site Number :1240003
London, Ontario, N6A 5A5, Canada
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Investigational Site Number :1240004
Edmonton, Alberta, T6G 2B7, Canada
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Investigational Site Number :1560001
Shanghai, 200040, China
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Investigational Site Number :1560002
Wuhan, 430030, China
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Investigational Site Number :1560003
Chengdu, 610041, China
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Investigational Site Number :3480001
Szeged, 6725, Hungary
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Investigational Site Number :3480002
Pécs, 7623, Hungary
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Investigational Site Number :3800001
Milan, 20132, Italy
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Investigational Site Number :3800002
Milan, Lombardy, 20133, Italy
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Investigational Site Number :3800003
Roma, 00168, Italy
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Investigational Site Number :3800004
Naples, 80131, Italy
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Investigational Site Number :3920002
Sagamihara-shi, Kanagawa, 252-0392, Japan
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Investigational Site Number :6160001
Zabrze, 41-800, Poland
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Investigational Site Number :7240003
L'Hospitalet de Llobregat, Catalunya [Cataluña], 08907, Spain
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Investigational Site Number :7240005
Madrid, Madrid, Comunidad de, 28046, Spain
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Investigational Site Number :8260001
Liverpool, L9 7LJ, United Kingdom
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Investigational Site Number :8260002
Exeter, Devon, EX2 5DW, United Kingdom
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Neurology Center of San Antonio, PA-Site Number:8400009
San Antonio, Texas, 00000, United States
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SFM Clinical Research, LLC-Site Number:8400006
Boca Raton, Florida, 33487, United States
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University of South Florida Health- Morsani Center for Advanced Healthcare-Site Number:8400001
Tampa, Florida, 33612-6601, United States
Conditions
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