New drug TLN-372 targets tough KRAS cancers in early trial
NCT ID NCT07204340
First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 37 times
Summary
This early-phase study tests a new drug called TLN-372 in people with advanced solid tumors that have a KRAS mutation. The goal is to check the drug's safety, how it moves through the body, and whether it can shrink tumors when used alone or with other cancer drugs. About 240 adults with measurable, advanced or spreading KRAS-mutant cancers that haven't spread to the brain are eligible to join.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215-5450, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitary Vall d'Hebron
RECRUITINGBarcelona, 08035, Spain
Contact
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Linear Clinical Research
RECRUITINGPerth, Western Australia, 6009, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10021-3402, United States
Contact Phone: •••-•••-••••
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Peter MacCallum Cancer Centre
RECRUITINGMelbourne, Victoria, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Princess Margaret Cancer Centre
RECRUITINGToronto, Ontario, M5G 1X6, Canada
Contact
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START Madrid_Hospital Universitario HM Sanchinarro_CIOCC
RECRUITINGMadrid, 28050, Spain
Contact
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START Midwest
RECRUITINGGrand Rapids, Michigan, 49546, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sarah Cannon Research Institute
RECRUITINGNashville, Tennessee, 37203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Email: •••••@•••••
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Washington University Medical Campus
RECRUITINGSt Louis, Missouri, 63108, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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