New pill targets bile duct cancer that resists standard treatments
NCT ID NCT05948475
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This Phase 3 trial tests an oral drug called tinengotinib against standard treatments chosen by the doctor for people with advanced bile duct cancer (cholangiocarcinoma) that has a specific genetic alteration (FGFR) and has stopped responding to chemotherapy and an FGFR inhibitor. The study compares how well tinengotinib controls the cancer and its side effects. Participants are randomly assigned to receive either tinengotinib or a standard chemotherapy regimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tinengotinib
- What this could lead to
- If successful, tinengotinib could offer a new oral treatment option for people with a specific type of bile duct cancer that has stopped responding to other therapies.
- What could go wrong
- This is an early-stage Phase 3 trial, and the drug may not prove more effective or safer than existing options. Side effects are possible, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AOUI Verona - Ospedale Borgo Roma
Verona, Italy
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ASST Grande Ospedale Metropolitano Niguard
Milan, Italy
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Amsterdam UMC, location AMC
Amsterdam, 1105 AZ, Netherlands
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Asklepios Klinik Altona
Hamburg, Germany
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Azienda Ospedaliera Universitaria Luigi Vanvitelli
Naples, Italy
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Azienda Ospedaliera Universitaria Senese Policlinico Le Scotte
Siena, Italy
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Azienda Ospedaliera Universitaria di Parma
Parma, Italy
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Azienda Ospedaliero-Universitaria Pisana
Pisa, Italy
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CHA Bundang Medical Center
Seongnam-si, Gyeonggi-do, 13496, South Korea
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Candiolo Cancer Institute - FPO IRCCS
Candiolo, 10060, Italy
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Centre Hospitalier Régional Universitaire de Besançon
Besançon, France
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Centre Hospitalier Universitaire de Montpellier
Montpellier, France
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Centro Hospitalar Lisboa Norte CHLN EPE - Hospital de Santa Maria
Lisbon, Portugal
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Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie
Warsaw, Poland
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Chang Gung Memorial Hospital CGMH - Kaohsiung Branch
Kaohsiung City, 833401, Taiwan
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Chonnam National University Hwasun Hospital
Hwasun, Jeollanam-do, 58128, South Korea
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Clinica Oncologica, Ospedali Riuniti Umberto 1
Ancona, Italy
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Clinica Universidad de Navarra
Madrid, Spain
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Clinica Universidad de Navarra
Pamplona, Spain
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Clinique de la Sauvegarde
Lyon, France
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Dong-A University Hospital
Busan, 49201, South Korea
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
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Fundação Champalimaud
Lisbon, Portugal
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Gachon University Gil Medical Center
Incheon, 21565, South Korea
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Gyeongsang National University Hospital
Jinju, Gyeongsangnam-do, 52727, South Korea
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HM Hospital Universitario Madrid Sanchinarro - CIOCC
Madrid, Spain
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Henry Ford
Detroit, Michigan, 48201, United States
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Hopital Beaujon
Clichy, France
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Hopital Franco-Britannique - Fondation Cognacq-Jay
Levallois-Perret, France
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Hopital Saint Antoine
Paris, France
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Hospital Clinico Universitario de Santiago de Compostela
Santiago de Compostela, Spain
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Hospital Clínic de Barcelona
Barcelona, Spain
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Hospital General Universitario Gregorio Maranon
Madrid, Spain
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Hospital Universitari Vall d´Hebron
Barcelona, Spain
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Hospital Universitario 12 de octubre
Madrid, Spain
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
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Hospital Universitario Miguel Servet
Zaragoza, Spain
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Hospital Universitario Ramón y Cajal
Madrid, Spain
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Hospital Universitario Reina Sofa
Córdoba, Spain
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Humanitas Research Hospital
Rozzano, Italy
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Inje University Haeundae Paik Hospital
Busan, 48108, South Korea
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Institut Sainte Catherine - Institut du Cancer Avignon Provence
Avignon, France
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Institut de Cancerologie Gustave Roussy
Villejuif, France
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Istituto Europeo di Oncologia IRCCS
Milan, Italy
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Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
Naples, Italy
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, Italy
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 80756, Taiwan
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Korea University Guro Hospital
Seoul, 08308, South Korea
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Krankenhaus Nordwest gGmbH
Frankfurt, Germany
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Krebszentrum Reutlingen
Baden, Germany
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Kyungpook National University Hospital
Daegu, 41944, South Korea
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Landesklinikum Wiener Neustadt
Wiener Neustadt, Austria
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Ludwig-Maximilians-Universität München Kum
München, Germany
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53202, United States
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Medizinische Hochschule Hannover
Hanover, Germany
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Messino Cancer Centers
Asheville, North Carolina, 28806, United States
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
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Ordensklinikum Linz GmbH
Linz, Austria
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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Royal Marsden Hospital NHS
London, United Kingdom
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Samsung Medical Center
Seoul, 06351, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Stanford Cancer Center
Stanford, California, 94305, United States
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Taichung Veterans General Hospital
Taichung, 40705, Taiwan
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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Tennessee Oncology- Nashville
Nashville, Tennessee, 37203, United States
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Texas Oncology-Sammons Cancer Center
Dallas, Texas, 75246, United States
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The Christie NHS Foundation Trust - Christie Hospital
Manchester, United Kingdom
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The University of Chicago Hospitals
Chicago, Illinois, 60601, United States
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The University of Kansas Cancer Center
Westwood, Los Angeles, California, 90024, United States
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77002, United States
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UCG-1st floor central
London, United Kingdom
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UCLA Medical Center
Santa Monica, California, 90401, United States
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UMass Memorial Medical Center
Worcester, Massachusetts, 01655, United States
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Universitaetsklinikum Heidelberg (UKHD) - Nationales Centrum fuer Tumorerkrankungen Heidelberg (NCT)
Heidelberg, Germany
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Universitair Ziekenhuis Antwerpen
Antwerp, Belgium
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Universitair Ziekenhuis Gent
Ghent, Belgium
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Universitair Ziekenhuis Leuven
Leuven, Belgium
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University of Michigan
Ann Arbor, Michigan, 48103, United States
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University of Minnesota- Masonic Cancer Center, M Health Fairview
Minneapolis, Minnesota, 55455, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75201, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37203, United States
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Yonsei University Health System - Severance Hospital
Seoul, 03722, South Korea
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