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New drug could help kidneys recover from sepsis

NCT ID NCT05996835

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jan 05, 2026 · Last updated May 16, 2026 · Updated 28 times

Summary

This study tests a new drug called TIN816 in 320 adults in the ICU who have kidney injury from sepsis. Participants get one dose of the drug or a placebo to see if it helps their kidneys work better. The goal is to find the best dose and check for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Baylor Scott and White

    Dallas, Texas, 75246, United States

  • Baystate Medical Center

    Springfield, Massachusetts, 01199, United States

  • Beth Israel Deaconess Med Center

    Boston, Massachusetts, 02215, United States

  • Emory Johns Creek Hospital

    Johns Creek, Georgia, 30097, United States

  • Good Samaritan Hospital

    Corvallis, Oregon, 97330, United States

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts, 01805, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Montefiore Medical Center

    The Bronx, New York, 10461, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Northwestern Memorial Hospital

    Evanston, Illinois, 60611, United States

  • Novartis Investigative Site

    CABA, Buenos Aires, C1118AAT, Argentina

  • Novartis Investigative Site

    Pilar, Buenos Aires, B1629AHJ, Argentina

  • Novartis Investigative Site

    CABA, C1181ACH, Argentina

  • Novartis Investigative Site

    Heidelberg, Victoria, 3084, Australia

  • Novartis Investigative Site

    Innsbruck, Tyrol, 6020, Austria

  • Novartis Investigative Site

    Genk, Limburg, 3600, Belgium

  • Novartis Investigative Site

    Brussels, 1200, Belgium

  • Novartis Investigative Site

    Ghent, 9000, Belgium

  • Novartis Investigative Site

    Ottignies, 1340, Belgium

  • Novartis Investigative Site

    São Paulo, São Paulo, 01327 001, Brazil

  • Novartis Investigative Site

    Salvador, 40323-010, Brazil

  • Novartis Investigative Site

    Montreal, Quebec, H2W 1T8, Canada

  • Novartis Investigative Site

    Montreal, Quebec, H4J 1C5, Canada

  • Novartis Investigative Site

    Québec, Quebec, G1V 4G5, Canada

  • Novartis Investigative Site

    Shijiazhuang, Hebei, 050011, China

  • Novartis Investigative Site

    Beijing, 100730, China

  • Novartis Investigative Site

    Guangzhou, 510260, China

  • Novartis Investigative Site

    Wuhan, 430022, China

  • Novartis Investigative Site

    Limoges, Haute Vienne, 87000, France

  • Novartis Investigative Site

    Argenteuil, 95107, France

  • Novartis Investigative Site

    Garches, 92380, France

  • Novartis Investigative Site

    Le Kremlin-Bicêtre, 94275, France

  • Novartis Investigative Site

    Nantes, 44093, France

  • Novartis Investigative Site

    Pessac, 33604, France

  • Novartis Investigative Site

    Strasbourg, 67091, France

  • Novartis Investigative Site

    Toulouse, 31054, France

  • Novartis Investigative Site

    Stuttgart, Baden-Wurttemberg, 70376, Germany

  • Novartis Investigative Site

    Munich, Bavaria, 81377, Germany

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60590, Germany

  • Novartis Investigative Site

    Jena, Thuringia, 07740, Germany

  • Novartis Investigative Site

    Kiel, 24105, Germany

  • Novartis Investigative Site

    Münster, 48149, Germany

  • Novartis Investigative Site

    Győr, H-9024, Hungary

  • Novartis Investigative Site

    Ahmedabad, Gujarat, 380060, India

  • Novartis Investigative Site

    Belagavi, Karnataka, 590010, India

  • Novartis Investigative Site

    New Delhi, National Capital Territory of Delhi, 110001, India

  • Novartis Investigative Site

    Hyderabad, Telangana, 500034, India

  • Novartis Investigative Site

    Rozzano, MI, 20089, Italy

  • Novartis Investigative Site

    Padova, PD, 35128, Italy

  • Novartis Investigative Site

    Roma, RM, 00168, Italy

  • Novartis Investigative Site

    Naples, 80131, Italy

  • Novartis Investigative Site

    Kamogawa, Chiba, 296-8602, Japan

  • Novartis Investigative Site

    Yokohama, Kanagawa, 245-8575, Japan

  • Novartis Investigative Site

    Kumamoto, Kumamoto, 860-0008, Japan

  • Novartis Investigative Site

    Izumisano, Osaka, 5988577, Japan

  • Novartis Investigative Site

    Osaka, Osaka, 5340021, Japan

  • Novartis Investigative Site

    Ureshino, Saga-ken, 843-0393, Japan

  • Novartis Investigative Site

    Izumo, Shimane, 693-8555, Japan

  • Novartis Investigative Site

    Hachiōji, Tokyo, 193-0998, Japan

  • Novartis Investigative Site

    Itabashi-ku, Tokyo, 1738610, Japan

  • Novartis Investigative Site

    Sabadell, Barcelona, 08208, Spain

  • Novartis Investigative Site

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    Barcelona, 08041, Spain

  • Novartis Investigative Site

    Madrid, 28040, Spain

  • Novartis Investigative Site

    Madrid, 28041, Spain

  • Novartis Investigative Site

    Valencia, 46026, Spain

  • Novartis Investigative Site

    Bangkok, 10330, Thailand

  • Novartis Investigative Site

    Bangkok, 10700, Thailand

  • Novartis Investigative Site

    Chiang Mai, 50200, Thailand

  • Novartis Investigative Site

    Birmingham, West Midlands, B15 2TH, United Kingdom

  • Novartis Investigative Site

    London, SE1 7EH, United Kingdom

  • Ohio State University Medical Center

    Columbus, Ohio, 43210, United States

  • Stanford Healthcare

    Stanford, California, 94305 5152, United States

  • U Of Pittsburgh Med Ctr

    Pittsburgh, Pennsylvania, 15213, United States

  • UC San Francisco Medical Center

    San Francisco, California, 94143-0116, United States

  • Univ Of Iowa Hospitals And Clinics

    Iowa City, Iowa, 52242, United States

  • University Of Alabama

    Birmingham, Alabama, 35233, United States

  • Utah Intermountain Medical Center

    Murray, Utah, 84107, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23298, United States

  • Wake Forest Univ School of Medicine

    Winston-Salem, North Carolina, 27157-1071, United States

Conditions

Explore the condition pages connected to this study.

ACUTE KIDNEY INJURY DUE TO SEPSIS