Experimental drug aims to rescue kidneys from sepsis damage

NCT ID NCT05996835

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a single dose of an experimental drug called TIN816 can help improve kidney function in hospitalized adults with severe infections (sepsis) that have caused sudden kidney injury. Researchers will compare three different doses of TIN816 against a placebo in about 320 patients in intensive care units. The main goal is to find the most effective and safe dose to help kidneys recover better and faster.

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Contacts and locations

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Locations

Baylor Scott and White

Dallas, Texas, 75246, United States
Baystate Medical Center

Springfield, Massachusetts, 01199, United States
Beth Israel Deaconess Med Center

Boston, Massachusetts, 02215, United States
Emory Johns Creek Hospital

Johns Creek, Georgia, 30097, United States
Good Samaritan Hospital

Corvallis, Oregon, 97330, United States
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Northwestern Memorial Hospital

Evanston, Illinois, 60611, United States
Novartis Investigative Site

CABA, Buenos Aires, C1118AAT, Argentina
Novartis Investigative Site

Pilar, Buenos Aires, B1629AHJ, Argentina
Novartis Investigative Site

CABA, C1181ACH, Argentina
Novartis Investigative Site

Santa Fe, S3000EPV, Argentina
Novartis Investigative Site

Herston, Queensland, 4029, Australia
Novartis Investigative Site

Heidelberg, Victoria, 3084, Australia
Novartis Investigative Site

Innsbruck, Tyrol, 6020, Austria
Novartis Investigative Site

Genk, Limburg, 3600, Belgium
Novartis Investigative Site

Brussels, 1200, Belgium
Novartis Investigative Site

Ghent, 9000, Belgium
Novartis Investigative Site

Ottignies, 1340, Belgium
Novartis Investigative Site

Brasília, Federal District, 70390-140, Brazil
Novartis Investigative Site

Curitiba, Paraná, 80010 030, Brazil
Novartis Investigative Site

Santo André, São Paulo, 09090-790, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 01327 001, Brazil
Novartis Investigative Site

Salvador, 40323-010, Brazil
Novartis Investigative Site

Vancouver, British Columbia, V6Z 1Y6, Canada
Novartis Investigative Site

Montreal, Quebec, H2W 1T8, Canada
Novartis Investigative Site

Montreal, Quebec, H4J 1C5, Canada
Novartis Investigative Site

Québec, Quebec, G1V 4G5, Canada
Novartis Investigative Site

Shijiazhuang, Hebei, 050011, China
Novartis Investigative Site

Hangzhou, Zhejiang, 310014, China
Novartis Investigative Site

Beijing, 100730, China
Novartis Investigative Site

Guangzhou, 510260, China
Novartis Investigative Site

Wuhan, 430022, China
Novartis Investigative Site

Limoges, Haute Vienne, 87000, France
Novartis Investigative Site

Argenteuil, 95107, France
Novartis Investigative Site

Garches, 92380, France
Novartis Investigative Site

Le Kremlin-Bicêtre, 94275, France
Novartis Investigative Site

Nantes, 44093, France
Novartis Investigative Site

Pessac, 33604, France
Novartis Investigative Site

Strasbourg, 67091, France
Novartis Investigative Site

Toulouse, 31054, France
Novartis Investigative Site

Munich, Bavaria, 81377, Germany
Novartis Investigative Site

Frankfurt am Main, Hesse, 60590, Germany
Novartis Investigative Site

Jena, Thuringia, 07740, Germany
Novartis Investigative Site

Kiel, 24105, Germany
Novartis Investigative Site

Münster, 48149, Germany
Novartis Investigative Site

Győr, H-9024, Hungary
Novartis Investigative Site

Ahmedabad, Gujarat, 380060, India
Novartis Investigative Site

Belagavi, Karnataka, 590010, India
Novartis Investigative Site

Pune, Maharashtra, 411001, India
Novartis Investigative Site

New Delhi, National Capital Territory of Delhi, 110001, India
Novartis Investigative Site

Hyderabad, Telangana, 500034, India
Novartis Investigative Site

Rozzano, MI, 20089, Italy
Novartis Investigative Site

Padua, PD, 35128, Italy
Novartis Investigative Site

Roma, RM, 00168, Italy
Novartis Investigative Site

Naples, 80131, Italy
Novartis Investigative Site

Kamogawa, Chiba, 296-8602, Japan
Novartis Investigative Site

Yokohama, Kanagawa, 2458575, Japan
Novartis Investigative Site

Kumamoto, Kumamoto, 860-0008, Japan
Novartis Investigative Site

Izumisano, Osaka, 5988577, Japan
Novartis Investigative Site

Osaka, Osaka, 5340021, Japan
Novartis Investigative Site

Ureshino, Saga-ken, 843-0393, Japan
Novartis Investigative Site

Izumo, Shimane, 693-8555, Japan
Novartis Investigative Site

Hachiōji, Tokyo, 193-0998, Japan
Novartis Investigative Site

Itabashi-ku, Tokyo, 1738610, Japan
Novartis Investigative Site

Sabadell, Barcelona, 08208, Spain
Novartis Investigative Site

Barcelona, 08035, Spain
Novartis Investigative Site

Barcelona, 08041, Spain
Novartis Investigative Site

Madrid, 28040, Spain
Novartis Investigative Site

Madrid, 28041, Spain
Novartis Investigative Site

Valencia, 46026, Spain
Novartis Investigative Site

Bangkok, 10330, Thailand
Novartis Investigative Site

Bangkok, 10400, Thailand
Novartis Investigative Site

Bangkok, 10700, Thailand
Novartis Investigative Site

Chiang Mai, 50200, Thailand
Novartis Investigative Site

Birmingham, West Midlands, B15 2TH, United Kingdom
Novartis Investigative Site

London, SE1 7EH, United Kingdom
Ohio State University Medical Center

Columbus, Ohio, 43210, United States
Stanford Healthcare

Stanford, California, 94305 5152, United States
Temple University

Philadelphia, Pennsylvania, 19140, United States
U Of Pittsburgh Med Ctr

Pittsburgh, Pennsylvania, 15213, United States
UC San Francisco Medical Center

San Francisco, California, 94143-0116, United States
Univ Of Iowa Hospitals And Clinics

Iowa City, Iowa, 52242, United States
University Of Alabama

Birmingham, Alabama, 35233, United States
Utah Intermountain Medical Center

Murray, Utah, 84107, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Wake Forest Univ School of Medicine

Winston-Salem, North Carolina, 27157-1071, United States

Conditions

Explore the condition pages connected to this study.

ACUTE KIDNEY INJURY DUE TO SEPSIS