Eye disease drug trial halted early

NCT ID NCT06307613

Terminated Disease control Sponsor: argenx Source: ClinicalTrials.gov ↗

Summary

This study tested whether a new injectable medication called efgartigimod could help adults with active, moderate-to-severe Thyroid Eye Disease. It compared the drug against a placebo injection to see if it could reduce eye bulging and improve quality of life. The trial was stopped early because an initial analysis found it was unlikely to show the intended benefit, though this was not due to safety concerns.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

A.LOUKAS General Hospital of Thessaloniki

Thessaloniki, 55236, Greece
ASST Santi Paolo e Carlo - Ospedale San Paolo

Milan, 20142, Italy
ASST Sete Laghi - Ospedale di Circolo e Fondazione Macchi di Varese

Varese, 21100, Italy
Advanced Research LLC

Coral Springs, Florida, 33067, United States
Athens Medical Group - European Interbalkan Medical Center

Thessaloniki, 57001, Greece
Axon Clinical s.r.o

Prague, 15000, Czechia
Azienda Ospedaliera Universitaria (AOU) Federico II

Naples, 80131, Italy
Azienda Ospedaliero Universitaria Careggi

Florence, 50134, Italy
Bascom Palmer Eye Institute

Miami, Florida, 33136, United States
Bradford Royal Infirmary - Bradford Teaching Hospitals NHS Foundation

Bradford, BD9 6RJ, United Kingdom
Budapest Retina Intezet

Budapest, 1133, Hungary
Buergerhospital Frankfurt am Main

Frankfurt, 60318, Germany
CHU UVC Brugmann - Site Victor Horta

Brussels, 1020, Belgium
Cardiff and Vale University Health Board - University Hospital of wales (UHW)

Cardiff, CF14 4XW, United Kingdom
Centre for Eye Research Australia

Melbourne, 3002, Australia
Centrul Medical Sana

Bucharest, 011025, Romania
Charite Universitaetsmedizin Berlin - Campus Charite Mitte (CCM)

Berlin, 10117, Germany
Dr Liina Viitas Endokrinoloog

Pärnu, 80018, Estonia
Duke University

Durham, North Carolina, 27705, United States
Faculty of Medicine Siriraj Hospital, Mahidol University

Bang Phlat, 10700, Thailand
Fakultni Nemocnice Olomouc - Ocni Klinika

Olomouc, 77900, Czechia
Fondazione Irccs Ca' Granda Ospedale Maggioe Policlinico Di Milano

Milan, 20122, Italy
Frimley Health NHS Foundation Trust - Frimley Park Hospital

Frimley, GU16 7UJ, United Kingdom
Fujian Medical University Union Hospital

Fuzhou, 350001, China
Ganglion Orvosi Kozpont

Pécs, 7621, Hungary
General Hospital of Athens G Gennimatas

Athens, 11527, Greece
Hospital Clinico Universitario De Santiago De Compostela

Santiago de Compostela, 15702, Spain
Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, 28222, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena

Seville, 41009, Spain
Institutul National de Endocrinologie C.I.Parhon

Bucharest, 011863, Romania
King Chulalongkorn Memorial Hospital

Bangkok, 10330, Thailand
Levenson Eye Associates

Jacksonville, Florida, 32204, United States
Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, 52000, Thailand
Markusovszky Teaching Hospital

Szombathely, 9700, Hungary
Medical Center Vereya EOOD - Vereya Medical Center (former Military Hospital)

Stara Zagora, 6008, Bulgaria
Moyes Eye Center - Northland

Kansas City, Missouri, 64154, United States
National University Hospital

Singapore, 119074, Singapore
North Shore Private Hospital

St Leonards, 2065, Australia
OFTEX - Ocni klinika

Pardubice, 53002, Czechia
Ospedale Policlinico San Martino

Genova, 16132, Italy
Oxycom Medical Centre

Burgas, 8000, Bulgaria
Pecsi Tudomanyegyetem (PTE) Altalanos Orvostudomanyi Kar (AOK) University of Pecs Medical School

Pécs, 7624, Hungary
Peking Union Medical College Hospital - Dongdan campus

Beijing, 100730, China
Penn Medicine - Penn Presbyterian Medical Center - Scheie Eye Institute

Philadelphia, Pennsylvania, 19104, United States
Quest Diagnostics - Mercy Smith Glynn Callaway

Springfield, Missouri, 65807, United States
Royal Victoria Infirmary - The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle, NE1 4LP, United Kingdom
Santa Chiara Hospital

Pisa, 56126, Italy
Shanghai Ninth People's Hospital of Shanghai Jiaotong University School of Medicine

Shanghai, 200011, China
Shunde Hospital of Southern Medical University

Foshan, 528399, China
Silkiss Eye Surgery

San Francisco, California, 94102, United States
Spitalul Clinic Judetean de Urgenta Sf. Spiridon

Iași, 700111, Romania
Spitalul Universitar De Urgenta Militar Central Dr. Carol Davila

Bucharest, 10825, Romania
Srinagarind Hospital

Khon Kaen, 40002, Thailand
St Thomas' Hospital - Guy's & St Thomas' NHS Foundation Trust

London, SE1 7EH, United Kingdom
St. Petka Eye Hospital - Eye Clinic St. Petka Varna

Varna, 9010, Bulgaria
Sydney Eye Hospital

Sydney, 2000, Australia
Tartu Ulikooli Kliinikum

Tartu, 50406, Estonia
The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, 471003, China
The First Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, 310003, China
The First Hospital of China Medical University

Shenyang, 110002, China
The Second Hospital of Anhui Medical University

Hefei, 230601, China
The University of Western Australia - Lions Eye Institute (LEI)

Nedlands, 6009, Australia
Thrive Health - Beverly Hills

Beverly Hills, California, 90210, United States
UCI Health - Gavin Herbert Eye Institute

Irvine, California, 92697, United States
UMHAT Aleksandrovska - Diagnostic Consultative Center (DCC) Aleksandrova

Sofia, 1431, Bulgaria
Universitaetsklinikum Muenster

Münster, 48149, Germany
Universitaetsklinikum der Ernst-Moritz-Arndt-Universitaet Greifswald

Greifswald, 17475, Germany
University General Hospital of Patras

Pátrai, 26504, Greece
University Of Southern California - Keck School Of Medicine

Los Angeles, California, 90033, United States
University of Illinois Chicago

Chicago, Illinois, 60612, United States
University of Michigan

Ann Arbour, Michigan, 48105, United States
University of South Florida (USF) Health - Morsani Center for Advanced Healthcare

Tampa, Florida, 33612, United States
Vadnay Szemeszet es Latszereszet

Eger, 3300, Hungary
Vseobecna fakultni nemocnice v Praze

Prague, 128 00, Czechia
West Virginia University Eye Institute

Morgantown, West Virginia, 26506, United States
Wilmer Eye Institute

Baltimore, Maryland, 21205, United States

Conditions

Explore the condition pages connected to this study.

THYROID EYE DISEASE