New drug combo targets Tough-to-Treat thyroid cancer

NCT ID NCT04940052

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing whether the drugs dabrafenib and trametinib can help control advanced thyroid cancer that has a specific genetic change (BRAF V600E mutation) and has stopped responding to radioactive iodine and other targeted therapies. It is a large, late-stage (Phase 3) trial where participants are randomly assigned to receive either the real drug combination or a placebo. The main goal is to see if the treatment can delay cancer growth and is safe for patients.

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Contacts and locations

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Locations

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Northwestern University Med School

Chicago, Illinois, 60611, United States
Novartis Investigative Site

CABA, Buenos Aires, C1417DTB, Argentina
Novartis Investigative Site

Rio de Janiero, Rio de Janeiro, 20231-050, Brazil
Novartis Investigative Site

Blumenau, Santa Catarina, 89015-200, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 01246-000, Brazil
Novartis Investigative Site

Edmonton, Alberta, T6G 1Z2, Canada
Novartis Investigative Site

London, Ontario, N6A 5W9, Canada
Novartis Investigative Site

Fuzhou, Fujian, 350014, China
Novartis Investigative Site

Zhengzhou, Henan, 450008, China
Novartis Investigative Site

Wuhan, Hubei, 430022, China
Novartis Investigative Site

Changsha, Hunan, 410013, China
Novartis Investigative Site

Nanjing, Jiangsu, 210006, China
Novartis Investigative Site

Nanjing, Jiangsu, 210009, China
Novartis Investigative Site

Xuzhou, Jiangsu, 221003, China
Novartis Investigative Site

Changchun, Jilin, 130033, China
Novartis Investigative Site

Chengdu, Sichuan, 610041, China
Novartis Investigative Site

Tianjin, Tianjin Municipality, 300121, China
Novartis Investigative Site

Beijing, 100036, China
Novartis Investigative Site

Beijing, 100730, China
Novartis Investigative Site

Guangzhou, 510060, China
Novartis Investigative Site

Shanghai, 200233, China
Novartis Investigative Site

Tianjin, 300052, China
Novartis Investigative Site

Tianjin, 300480, China
Novartis Investigative Site

Hisar, Haryana, 125005, India
Novartis Investigative Site

New Delhi, National Capital Territory of Delhi, 110029, India
Novartis Investigative Site

Chennai, 600 020, India
Novartis Investigative Site

George Town, Pulau Pinang, 10450, Malaysia
Novartis Investigative Site

Kuching, Sarawak, 93586, Malaysia
Novartis Investigative Site

Kuala Lumpur, 59100, Malaysia
Novartis Investigative Site

Seoul, Korea, 03080, South Korea
Novartis Investigative Site

Seoul, 05505, South Korea
Novartis Investigative Site

Seoul, 06351, South Korea
Novartis Investigative Site

Seoul, 06591, South Korea
Novartis Investigative Site

Tainan, 70403, Taiwan
Novartis Investigative Site

Taipei, 10002, Taiwan
Novartis Investigative Site

Istanbul, Fatih, 34098, Turkey (Türkiye)
Novartis Investigative Site

Edirne, Merkez, 22030, Turkey (Türkiye)
Novartis Investigative Site

Ankara, Yenimahalle, 06500, Turkey (Türkiye)
Novartis Investigative Site

Adana, Yuregir, 01250, Turkey (Türkiye)
Novartis Investigative Site

Hanoi, 100000, Vietnam

Conditions

Explore the condition pages connected to this study.

DIFFERENTIATED THYROID CANCER (DTC)