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Tiny study: black seed oil changes gut bugs

NCT ID NCT07450807

Knowledge-focused Sponsor: Aysun Tekbaş Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether thymoquinone, the main active compound in black seed oil, changes the types of bacteria living in the human gut. Eight healthy adults took black seed oil capsules for 20 days and gave stool samples at five time points. The goal was to see if the oil could help gut healing after surgery, but this was just an early, small study to check for changes in gut bacteria.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Thymoquinone (from black seed oil)
What this could lead to
If this works, it could point toward using black seed oil to support gut health, especially after surgery.
What could go wrong
This was a very small study (8 people) in healthy adults, with no control group. Results may not apply to sick people or lead to any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

8 people

The number who actually took part.

Started

Apr 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * no recent medication use * no history of gastrointestinal surgery * no pregnancy * no allergies to NSSO or its derivatives * healthy * 18 years and above Exclusion Criteria: * regular medication * history of gastrointestinal surgery * pregnancy * allergies to NSSO or its derivates * presence of chronic illness * below the age of 18 years

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Changes in human gut microbiome in healthy adults

Contacts and locations

Locations

  • Jena University Hospital

    Jena, Thuringia, 07747, Germany