New pill aims to boost energy for people with inherited blood disorder

NCT ID NCT04770753

Summary

This study tested whether an oral medication called mitapivat could improve anemia and reduce fatigue in adults with non-transfusion-dependent thalassemia, a genetic blood disorder. About 194 participants were randomly assigned to receive either mitapivat or a placebo pill for 24 weeks. Researchers measured changes in hemoglobin levels (a key marker of anemia) and asked participants about their fatigue and quality of life.

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Contacts and locations

Locations

  • A.O.R.N. "A. Cardarelli"

    Naples, 80131, Italy

  • A.O.U Di Modena

    Modena, 41124, Italy

  • A.O.U. San Luigi Gonzaga

    Orbassano, 10043, Italy

  • AOU L. Vanvitelli Universita degli Studi della Campania Luigi Vanvitelli

    Naples, 80138, Italy

  • Acibadem Adana Hospital

    Adana, 01130, Turkey (Türkiye)

  • Akdeniz University Faculty of Medicine

    Antalya, 07059, Turkey (Türkiye)

  • Burjeel Medical City

    Abu Dhabi, United Arab Emirates

  • CHU Hôpital Henri Mondor

    Créteil, 94010, France

  • Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital

    Cambridge, CAM, CB2 0QQ, United Kingdom

  • Children's Hospital Agia Sophia, National and Kapodistrian University of Athens Medical School

    Athens, 115 27, Greece

  • China Medical University, Taiwan

    Taichung, 40447, Taiwan

  • Chronic Care Center

    Beirut, 9999, Lebanon

  • Duke University Medical Center

    Durham, North Carolina, 27710-3038, United States

  • Ege University Faculty of Medicine

    Bornova, 35040, Turkey (Türkiye)

  • Ente Ospedaliero Ospedali Galliera

    Genova, 16128, Italy

  • Erasmus MC

    Rotterdam, 3015 GD, Netherlands

  • Faculty of Medicine Siriraj Hospital

    Bangkok, 10700, Thailand

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • GSH Banco de Sangue de São Paulo

    São Paulo, 04006-002, Brazil

  • HEMORIO Instituto Nacional de Hematologia

    Rio de Janeiro, 20211-030, Brazil

  • Hacettepe University

    Mersin, 06230, Turkey (Türkiye)

  • Hopital Edouard Herriot, CHU de Lyon

    Lyon, 69003, France

  • Hospital Ampang

    Ampang, 68000, Malaysia

  • Hospital Pulau Pinang

    Pulau Pinang, 10990, Malaysia

  • Hospital Queen Elizabeth, Kota Kinabalu

    Kota Kinabalu, 88586, Malaysia

  • Hospital Sultanah Aminah Johor Bahru

    Johor Bahru, 80100, Malaysia

  • Hospital Sultanah Bahiyah

    Alor Star, 05460, Malaysia

  • Hospital Tengku Ampuan Afzan

    Kuantan, 25100, Malaysia

  • Hospital Tunku Azizah

    Kuala Lumpur, 50300, Malaysia

  • Hospital Umum Sarawak

    Kuching, 93586, Malaysia

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen Arrixaca

    Murcia, 30120, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, 41013, Spain

  • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP

    Ribeirão Preto, 14051-260, Brazil

  • Imperial College Healthcare NHS Trust - Hammersmith Hospital

    London, W12 OHS, United Kingdom

  • Instituto do Cancer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidad de São Paulo

    São Paulo, 05403-000, Brazil

  • Ippokrateio General Hospital

    Thessaloniki, 546 42, Greece

  • Istanbul University Faculty of Medicine

    Fatih, 34093, Turkey (Türkiye)

  • King Abdulaziz Hospital - Al Ahsa

    Al Mubarraz, 36428, Saudi Arabia

  • King Abdullah International Medical Research Center

    Riyadh, 14611, Saudi Arabia

  • King Chulalongkorn Memorial Hospital

    Pathum Wan, 10330, Thailand

  • Laiko General Hospital

    Athens, 115 26, Greece

  • MHAT "Dr. Nikola Vasiliev" AD

    Kyustendil, 2500, Bulgaria

  • Maharaj Nakorn Chiang Mai Hospital

    Chiang Mai, 50200, Thailand

  • Manchester Royal Infirmary, Manchester University NHS Foundation Trust

    Manchester, LAN, M13 9WL, United Kingdom

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114-2696, United States

  • Naresuan University Hospital

    Mueang Phitsanulok, 65000, Thailand

  • Ospedale "A. Perrino" - Brindisi

    Brindisi, 72100, Italy

  • Ospedale Pediatrico Microcitemico

    Cagliari, 09121, Italy

  • Ospedale Sant'Anna

    Ferrara, 44124, Italy

  • Penn Medicine - University of Pennsylvania Health System

    Philadelphia, Pennsylvania, 19104, United States

  • Phramongkutklao Hospital

    Bangkok, 10400, Thailand

  • Praxis Pesquisa Medica

    Santo André, 09090-790, Brazil

  • Ramathibodi Hospital

    Bangkok, 10400, Thailand

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • SHATHD Sofia

    Sofia, 1756, Bulgaria

  • San Diego Hospital, UC San Diego Health

    La Jolla, California, 92093, United States

  • Srinagarind Hospital, Khon Kaen University

    Khon Kaen, 40002, Thailand

  • Stanford Medicine

    Palo Alto, California, 94304-1601, United States

  • Thalassemia Centre Dubai

    Dubai, 4545, United Arab Emirates

  • Toronto General Hospital, University Health Network

    Toronto, M5G 2C4, Canada

  • Universidade de Caxias do Sul

    Caxias do Sul, 95070-560, Brazil

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX, Netherlands

  • University College London

    London, NW1 2PG, United Kingdom

  • University General Hospital of Patras

    Rio, 26504, Greece

  • Weill Cornell Medical Center

    New York, New York, 10065-4870, United States

  • Çukurova University

    Balcalı, 01330, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.