New pill aims to boost energy for people with inherited blood disorder
NCT ID NCT04770753
Summary
This study tested whether an oral medication called mitapivat could improve anemia and reduce fatigue in adults with non-transfusion-dependent thalassemia, a genetic blood disorder. About 194 participants were randomly assigned to receive either mitapivat or a placebo pill for 24 weeks. Researchers measured changes in hemoglobin levels (a key marker of anemia) and asked participants about their fatigue and quality of life.
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Contacts and locations
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Locations
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A.O.R.N. "A. Cardarelli"
Naples, 80131, Italy
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A.O.U Di Modena
Modena, 41124, Italy
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A.O.U. San Luigi Gonzaga
Orbassano, 10043, Italy
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AOU L. Vanvitelli Universita degli Studi della Campania Luigi Vanvitelli
Naples, 80138, Italy
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Acibadem Adana Hospital
Adana, 01130, Turkey (Türkiye)
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Akdeniz University Faculty of Medicine
Antalya, 07059, Turkey (Türkiye)
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Burjeel Medical City
Abu Dhabi, United Arab Emirates
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CHU Hôpital Henri Mondor
Créteil, 94010, France
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Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital
Cambridge, CAM, CB2 0QQ, United Kingdom
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Children's Hospital Agia Sophia, National and Kapodistrian University of Athens Medical School
Athens, 115 27, Greece
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China Medical University, Taiwan
Taichung, 40447, Taiwan
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Chronic Care Center
Beirut, 9999, Lebanon
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Duke University Medical Center
Durham, North Carolina, 27710-3038, United States
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Ege University Faculty of Medicine
Bornova, 35040, Turkey (Türkiye)
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Ente Ospedaliero Ospedali Galliera
Genova, 16128, Italy
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Erasmus MC
Rotterdam, 3015 GD, Netherlands
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Faculty of Medicine Siriraj Hospital
Bangkok, 10700, Thailand
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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GSH Banco de Sangue de São Paulo
São Paulo, 04006-002, Brazil
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HEMORIO Instituto Nacional de Hematologia
Rio de Janeiro, 20211-030, Brazil
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Hacettepe University
Mersin, 06230, Turkey (Türkiye)
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Hopital Edouard Herriot, CHU de Lyon
Lyon, 69003, France
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Hospital Ampang
Ampang, 68000, Malaysia
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Hospital Pulau Pinang
Pulau Pinang, 10990, Malaysia
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Hospital Queen Elizabeth, Kota Kinabalu
Kota Kinabalu, 88586, Malaysia
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Hospital Sultanah Aminah Johor Bahru
Johor Bahru, 80100, Malaysia
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Hospital Sultanah Bahiyah
Alor Star, 05460, Malaysia
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Hospital Tengku Ampuan Afzan
Kuantan, 25100, Malaysia
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Hospital Tunku Azizah
Kuala Lumpur, 50300, Malaysia
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Hospital Umum Sarawak
Kuching, 93586, Malaysia
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Virgen Arrixaca
Murcia, 30120, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP
Ribeirão Preto, 14051-260, Brazil
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Imperial College Healthcare NHS Trust - Hammersmith Hospital
London, W12 OHS, United Kingdom
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Instituto do Cancer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidad de São Paulo
São Paulo, 05403-000, Brazil
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Ippokrateio General Hospital
Thessaloniki, 546 42, Greece
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Istanbul University Faculty of Medicine
Fatih, 34093, Turkey (Türkiye)
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King Abdulaziz Hospital - Al Ahsa
Al Mubarraz, 36428, Saudi Arabia
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King Abdullah International Medical Research Center
Riyadh, 14611, Saudi Arabia
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King Chulalongkorn Memorial Hospital
Pathum Wan, 10330, Thailand
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Laiko General Hospital
Athens, 115 26, Greece
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MHAT "Dr. Nikola Vasiliev" AD
Kyustendil, 2500, Bulgaria
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Maharaj Nakorn Chiang Mai Hospital
Chiang Mai, 50200, Thailand
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Manchester Royal Infirmary, Manchester University NHS Foundation Trust
Manchester, LAN, M13 9WL, United Kingdom
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Massachusetts General Hospital
Boston, Massachusetts, 02114-2696, United States
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Naresuan University Hospital
Mueang Phitsanulok, 65000, Thailand
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Ospedale "A. Perrino" - Brindisi
Brindisi, 72100, Italy
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Ospedale Pediatrico Microcitemico
Cagliari, 09121, Italy
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Ospedale Sant'Anna
Ferrara, 44124, Italy
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Penn Medicine - University of Pennsylvania Health System
Philadelphia, Pennsylvania, 19104, United States
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Phramongkutklao Hospital
Bangkok, 10400, Thailand
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Praxis Pesquisa Medica
Santo André, 09090-790, Brazil
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Ramathibodi Hospital
Bangkok, 10400, Thailand
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Rigshospitalet
Copenhagen, 2100, Denmark
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SHATHD Sofia
Sofia, 1756, Bulgaria
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San Diego Hospital, UC San Diego Health
La Jolla, California, 92093, United States
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Srinagarind Hospital, Khon Kaen University
Khon Kaen, 40002, Thailand
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Stanford Medicine
Palo Alto, California, 94304-1601, United States
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Thalassemia Centre Dubai
Dubai, 4545, United Arab Emirates
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Toronto General Hospital, University Health Network
Toronto, M5G 2C4, Canada
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Universidade de Caxias do Sul
Caxias do Sul, 95070-560, Brazil
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Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
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University College London
London, NW1 2PG, United Kingdom
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University General Hospital of Patras
Rio, 26504, Greece
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Weill Cornell Medical Center
New York, New York, 10065-4870, United States
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Çukurova University
Balcalı, 01330, Turkey (Türkiye)
Conditions
Explore the condition pages connected to this study.