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Could a simple blood test spare thousands from chemo?

NCT ID NCT07084558

Recruiting now Disease control Sponsor: Austrian Breast & Colorectal Cancer Study Group Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for people with a common type of early breast cancer (HR-positive, HER2-negative) that is likely to respond to hormone therapy. Researchers want to see if taking hormone pills for 8 months works just as well as chemotherapy, but with fewer side effects. Participants are assigned to either hormone therapy or chemo based on blood tests and a biopsy after a short hormone run-in. The goal is to find out if the tumor responds enough to skip chemo safely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
aromatase inhibitors (AI) or tamoxifen
What this could lead to
If successful, this could show that many women with early breast cancer can avoid chemotherapy and its side effects, using only hormone therapy without losing effectiveness.
What could go wrong
This is a phase 2 study with 350 participants, so results are not definitive. The approach relies on specific biomarkers (ctDNA and Ki-67) that may not perfectly predict treatment response, and some patients may still need chemo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY AND LOCALLY ADVANCED BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Allg. Gynäkologie u. gyn. Onkologie/Senologie

    RECRUITING

    Vienna, Austria, 1190, Austria

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Dornbirn BGZ; Frauenheilkunde u. Geburtshilfe

    ACTIVE_NOT_RECRUITING

    Dornbirn, Austria

  • Hanusch Krankenhaus, 3. Medizinische Abteilung

    ACTIVE_NOT_RECRUITING

    Vienna, Austria

  • KH BHB St. Veit/Glan Brustzentrum Kärnten

    ACTIVE_NOT_RECRUITING

    Sankt Veit an der Glan, Austria

  • Klinik Hietzing, Gyn. Abteilung; Karl Landsteiner Institut f. gyn. Onkologie u. Senologie

    ACTIVE_NOT_RECRUITING

    Vienna, Austria

  • LKH Salzburg - PMU, Univ.Klinik f. Innere Medizin III / SCRI CCCIT

    NOT_YET_RECRUITING

    Salzburg, Austria

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Landesklinikum Baden BGZ; Abt. f. Allgemein- u. Viszeralchirurgie

    ACTIVE_NOT_RECRUITING

    Baden, Austria

  • Landeskrankenhaus Feldkirch Interne E

    ACTIVE_NOT_RECRUITING

    Feldkirch, Austria

  • MUG - LKH Graz Klin. Abt. f. Onkologie

    ACTIVE_NOT_RECRUITING

    Graz, Austria

  • MUG - Univ. Frauenklinik Graz, Gyn. Abteilung

    ACTIVE_NOT_RECRUITING

    Graz, Austria

  • MUI - Univ. Klinik f. Frauenheilkunde Innsbruck Klin. Abteilung f. Gynäkologie u. Geburtshilfe

    RECRUITING

    Innsbruck, Austria

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • TumorZentrum Kepler Universitätsklinikum Linz

    ACTIVE_NOT_RECRUITING

    Linz, Austria

  • Universitätsklinikum St. Pölten, Klin. Abteilung f. Innere Medizin 1

    ACTIVE_NOT_RECRUITING

    Sankt Pölten, Austria

  • Universitätsklinikum Wiener Neustadt, Abteilung für Innere Medizin, Hämatologie und int. Onkologie

    NOT_YET_RECRUITING

    Wiener Neustadt, Austria

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••